Marburg hemorrhagic fever natural history, complications and prognosis

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Marburg hemorrhagic fever Microchapters

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Differentiating Marburg hemorrhagic fever from other Diseases

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Natural History, Complications and Prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief:

Overview

Case fatality rates in Marburg hemorrhagic fever outbreaks have ranged from 23% to 90%.

Natural History

Marburg hemorrhagic fever: Symptoms and Disease Progression
Generalisation Phase (Day 1 to Day 5)
  • Fever
  • Headache
  • Chills
  • Myalgia
  • Malaise
  • Fatigue
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal Pain
  • Conjunctivitis
  • Rash
  • Pharyngitis
Early Organ Phase (Day 6 to Day 13)
  • Fever
  • Bloody Diarrhoea(Malena)
  • Hematemesis
  • Exanthema
  • Petechiae/Ecchymoses
  • Muscosal hemorrhage
  • Visceral hemorrhage
  • Dyspnea
  • Conjunctival injection
  • Edema
  • Apathy/Depression
  • Irritability/Aggression
Late Organ or Convalescence Phase (Day 14 to Day 21)
  • Fever
  • Obtundation
  • Dementia
  • Coma
  • Convulsions
  • Diffuse coagulopathy
  • Metabolic disturbances
  • Shock
  • Myalgia
  • Arthralgia
  • Hepatitis
  • Asthenia
  • Ocular disease
  • Psychosis
  • Social separation

Complications

Prognosis

References