Macroglossia
| Macroglossia | |
| ICD-10 | Q38.2 |
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| ICD-9 | 529.8 |
| OMIM | 153630 |
| DiseasesDB | 7689 |
| MeSH | D008260 |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Macroglossia is the medical term for unusual enlargement (hypertrophy) of the tongue. Severe enlargement of the tongue can cause cosmetic and functional difficulties including in speaking, eating, swallowing and sleeping.
Causes
Macroglossia is a feature of the following disorders:
- Acromegaly
- Amyloidosis (in primary and myeloma-related)
- Beckwith-Wiedemann syndrome
- Congenital hypothyroidism
- Hurler syndrome
- Immunodeficiency, centromere instability and facial anomalies syndrome
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Common Causes
Causes by Organ System
| Cardiovascular | Cardiac amyloidosis, amyloidosis |
| Chemical / poisoning | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | |
| Ear Nose Throat | |
| Endocrine | Acromegaly, congenital hypothyroidism, growth hormone secreting pituitary adenoma, hypothyroidism, congenital hypothyroidism |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | Chromosome 12p tetrasomy syndrome, chromosome 9q deletion syndrome, congenital micrognathia, down syndrome, gM1 gangliosidoses, gM3 gangliosidoses, glycogen storage disease, Hunter syndrome, Hurler syndrome, Limb-girdle muscular dystrophy, lymphoma, monoclonal gammopathy of undetermined significance, I-cell disease, omphalocele, Smith-Lemli-Opitz syndrome, Pompe disease, Potocki-Lupski syndrome, Simpson-Golabi-Behmel syndrome, tongue cancer, Beckwith-Wiedemann syndrome |
| Hematologic | Multiple myeloma |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal / Ortho | Acromegaly, Beckwith-Wiedemann syndrome, congenital hypothyroidism, cystic hygroma, Limb-girdle muscular dystrophy, multiple myeloma |
| Neurologic | |
| Nutritional / Metabolic | Cardiac amyloidosis, amyloidosis, gM1 gangliosidoses, gM3 gangliosidoses, Hunter syndrome, immunoglobulin light chain amyloidosis, I-cell disease, Pompe disease, Potocki-Lupski syndrome |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | |
| Overdose / Toxicity | No underlying causes |
| Psychiatric | |
| Pulmonary | No underlying causes |
| Renal / Electrolyte | |
| Rheum / Immune / Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
Template:Congenital malformations and deformations of digestive system