Macroglossia

Macroglossia
ICD-10	Q38.2
ICD-9	529.8
OMIM	153630
DiseasesDB	7689
MeSH	D008260

WikiDoc Resources for Macroglossia
Articles
Most recent articles on Macroglossia Most cited articles on Macroglossia Review articles on Macroglossia Articles on Macroglossia in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Macroglossia Images of Macroglossia Photos of Macroglossia Podcasts & MP3s on Macroglossia Videos on Macroglossia
Evidence Based Medicine
Cochrane Collaboration on Macroglossia Bandolier on Macroglossia TRIP on Macroglossia
Clinical Trials
Ongoing Trials on Macroglossia at Clinical Trials.gov Trial results on Macroglossia Clinical Trials on Macroglossia at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Macroglossia NICE Guidance on Macroglossia NHS PRODIGY Guidance FDA on Macroglossia CDC on Macroglossia
Books
Books on Macroglossia
News
Macroglossia in the news Be alerted to news on Macroglossia News trends on Macroglossia
Commentary
Blogs on Macroglossia
Definitions
Definitions of Macroglossia
Patient Resources / Community
Patient resources on Macroglossia Discussion groups on Macroglossia Patient Handouts on Macroglossia Directions to Hospitals Treating Macroglossia Risk calculators and risk factors for Macroglossia
Healthcare Provider Resources
Symptoms of Macroglossia Causes & Risk Factors for Macroglossia Diagnostic studies for Macroglossia Treatment of Macroglossia
Continuing Medical Education (CME)
CME Programs on Macroglossia
International
Macroglossia en Espanol Macroglossia en Francais
Business
Macroglossia in the Marketplace Patents on Macroglossia
Experimental / Informatics
List of terms related to Macroglossia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Macroglossia is the medical term for unusual enlargement (hypertrophy) of the tongue. Severe enlargement of the tongue can cause cosmetic and functional difficulties including in speaking, eating, swallowing and sleeping.

Causes

Macroglossia is a feature of the following disorders:

• Acromegaly
• Amyloidosis (in primary and myeloma-related)
• Beckwith-Wiedemann syndrome
• Congenital hypothyroidism
• Hurler syndrome
• Immunodeficiency, centromere instability and facial anomalies syndrome

Overview

The sclera is a vascularized connective tissue structure of the eye composed of several types of collagen fibers, mainly collagen type I as well as elastin, proteoglycans and glycoproteins. Blue sclera is caused by the slimness and transparency of the collagen fibers of the sclera that allow the visualization of the uvea.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

• Alkaptonuria
• Ehlers-Danlos Syndrome
• Hypophosphatasia
• Juvenile Paget's disease
• Marfan's syndrome
• Osteogenesis imperfecta
• Pseudoxanthoma elasticum

Causes by Organ System

Cardiovascular	Loeys-Dietz syndrome,
Chemical / poisoning	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Retigabine
Ear Nose Throat	Van der Hoeve's Syndrome
Endocrine	Laron dwarfism
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	Alkaptonuria , developmental delay hypotonia extremities hypertrophy, Ehlers-Danlos Syndrome, incontinentia pigmenti, Juvenile Paget's disease, laron dwarfism, lobstein disease , Loeys-Dietz syndrome, marfan's syndrome , marshall-smith-weaver syndrome, Jansen's metaphyseal chondrodysplasia, osteogenesis imperfecta, recurrent hereditary polyserositis, willems de vries syndrome.
Hematologic	Diamond-Blackfan anemia, hypophosphatasia.
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal / Ortho	Ehlers-Danlos Syndrome, Juvenile Paget's disease, lobstein disease , Loeys-Dietz syndrome, marfan's syndrome , marshall-smith-weaver syndrome, Jansen's metaphyseal chondrodysplasia, osteogenesis imperfecta, osteoporosis-pseudoglioma syndrome, pelvic dysplasia arthrogryposis of lower limbs, pilo dento ungular dysplasia microcephaly, pseudoxanthoma elasticum, ray-peterson-scott syndrome, spondyloepimetaphyseal dysplasia joint laxity, Van der Hoeve's Syndrome.
Neurologic	Bd syndrome, chitayat-moore-del bigio syndrome, daentl-townsend-siegel syndrome, developmental delay hypotonia extremities hypertrophy, osteoporosis-pseudoglioma syndrome, ray-peterson-scott syndrome.
Nutritional / Metabolic	Alkaptonuria , hypophosphatasia.
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Ophthalmologic	Alkaptonuria , Bd syndrome, Diamond-Blackfan anemia, Grant syndrome, hypophosphatasia, incontinentia pigmenti , Jansen's metaphyseal chondrodysplasia, osteogenesis imperfecta, recurrent hereditary polyserositis, Van der Hoeve's Syndrome, Vater-like syndrome, with pulmonary hypertension, abnormal ears and growth deficiency .
Overdose / Toxicity	No underlying causes
Psychiatric	Chitayat-moore-del bigio syndrome
Pulmonary	No underlying causes
Renal / Electrolyte	Daentl-townsend-siegel syndrome
Rheum / Immune / Allergy	No underlying causes
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes