MYH1

Myosin, heavy chain 1, skeletal muscle, adult
File:PBB Protein MYH1 image.jpg PDB rendering based on 1m8q.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1m8q​, 1mvw​, 1o18​, 1o19​, 1o1a​, 1o1b​, 1o1c​, 1o1d​, 1o1e​, 1o1f​, 1o1g​
Identifiers
Symbols	MYH1 ; MGC133384; MYHSA1; MYHa; MyHC-2X/D
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68493
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE MYH1 205951 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Myosin, heavy chain 1, skeletal muscle, adult, also known as MYH1, is a human gene.

Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development.

Further reading

• Yoon SJ, Seiler SH, Kucherlapati R, Leinwand L (1993). "Organization of the human skeletal myosin heavy chain gene cluster". Proc. Natl. Acad. Sci. U.S.A. 89 (24): 12078–82. PMID 1465443.CS1 maint: Multiple names: authors list (link)
• Saez L, Leinwand LA (1986). "Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle". Nucleic Acids Res. 14 (7): 2951–69. PMID 2421254.
• Leinwand LA, Saez L, McNally E, Nadal-Ginard B (1983). "Isolation and characterization of human myosin heavy chain genes". Proc. Natl. Acad. Sci. U.S.A. 80 (12): 3716–20. PMID 6304733.CS1 maint: Multiple names: authors list (link)
• Smerdu V, Karsch-Mizrachi I, Campione M; et al. (1995). "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle". Am. J. Physiol. 267 (6 Pt 1): C1723–8. PMID 7545970.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weiss A, McDonough D, Wertman B; et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. PMID 10077619.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.CS1 maint: Multiple names: authors list (link)
• Daugaard JR, Nielsen JN, Kristiansen S; et al. (2000). "Fiber type-specific expression of GLUT4 in human skeletal muscle: influence of exercise training". Diabetes. 49 (7): 1092–5. PMID 10909963.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Korfage JA, Brugman P, Van Eijden TM (2000). "Intermuscular and intramuscular differences in myosin heavy chain composition of the human masticatory muscles". J. Neurol. Sci. 178 (2): 95–106. PMID 11018701.CS1 maint: Multiple names: authors list (link)
• Konig S, Burkman J, Fitzgerald J; et al. (2002). "Modular organization of phylogenetically conserved domains controlling developmental regulation of the human skeletal myosin heavy chain gene family". J. Biol. Chem. 277 (31): 27593–605. doi:10.1074/jbc.M203162200. PMID 11971910.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs". Nucleic Acids Res. 32 (8): 2411–20. doi:10.1093/nar/gkh552. PMID 15121898.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pontén EM, Stål PS (2007). "Decreased capillarization and a shift to fast myosin heavy chain IIx in the biceps brachii muscle from young adults with spastic paresis". J. Neurol. Sci. 253 (1–2): 25–33. doi:10.1016/j.jns.2006.11.006. PMID 17196619.