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{{Infobox_gene}}
{{PBB_Controls
'''Myotubularin-related protein 9''' is a [[protein]] that in humans is encoded by the ''MTMR9'' [[gene]].<ref name="pmid11472061">{{cite journal | vauthors = Appel S, Reichwald K, Zimmermann W, Reis A, Rosenthal A, Hennies HC | title = Identification and localization of a new human myotubularin-related protein gene, mtmr8, on 8p22-p23 | journal = Genomics | volume = 75 | issue = 1-3 | pages = 6–8  | date = Jul 2001 | pmid = 11472061 | pmc =  | doi = 10.1006/geno.2001.6591 }}</ref><ref name="pmid11896452">{{cite journal | vauthors = Appel S, Filter M, Reis A, Hennies HC, Bergheim A, Ogilvie E, Arndt S, Simmons A, Lovett M, Hide W, Ramsay M, Reichwald K, Zimmermann W, Rosenthal A | title = Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759 | journal = Eur. J. Hum. Genet. | volume = 10 | issue = 1 | pages = 17–25  | date = Mar 2002 | pmid = 11896452 | pmc =  | doi = 10.1038/sj.ejhg.5200750 }}</ref><ref name="pmid12890864">{{cite journal | vauthors = Mochizuki Y, Majerus PW | title = Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 17 | pages = 9768–73  | date = Aug 2003 | pmid = 12890864 | pmc = 187840 | doi = 10.1073/pnas.1333958100 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MTMR9 myotubularin related protein 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=66036| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Myotubularin related protein 9
| HGNCid = 14596
| Symbol = MTMR9
| AltSymbols =; MTMR8; C8orf9; DKFZp434K171; LIP-STYX; MGC126672
| OMIM = 606260
| ECnumber = 
| Homologene = 9148
| MGIid = 2442842
| GeneAtlas_image1 = PBB_GE_MTMR9_204837_at_tn.png
| GeneAtlas_image2 = PBB_GE_MTMR9_213278_at_tn.png
| Function = {{GNF_GO|id=GO:0004437 |text = inositol or phosphatidylinositol phosphatase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030234 |text = enzyme regulator activity}}
| Component =
| Process = {{GNF_GO|id=GO:0046839 |text = phospholipid dephosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 66036
    | Hs_Ensembl = ENSG00000104643
    | Hs_RefseqProtein = NP_056273
    | Hs_RefseqmRNA = NM_015458
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 11179394
    | Hs_GenLoc_end = 11223080
    | Hs_Uniprot = Q96QG7
    | Mm_EntrezGene = 210376
    | Mm_Ensembl = ENSMUSG00000035078
    | Mm_RefseqmRNA = NM_177594
    | Mm_RefseqProtein = NP_808262
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 62477587
    | Mm_GenLoc_end = 62498078
    | Mm_Uniprot = Q3U896
  }}
}}
'''Myotubularin related protein 9''', also known as '''MTMR9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MTMR9 myotubularin related protein 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=66036| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.<ref name="entrez">{{cite web | title = Entrez Gene: MTMR9 myotubularin related protein 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=66036| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MTMR9 has been shown to [[Protein-protein interaction|interact]] with [[MTMR6]].<ref name=pmid12890864 />
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
* {{cite journal | vauthors = Wang JC, Radford DM, Holt MS, Helms C, Goate A, Brandt W, Parik M, Phillips NJ, DeSchryver K, Schuh ME, Fair KL, Ritter JH, Marshall P, Donis-Keller H | title = Sequence-ready contig for the 1.4-cM ductal carcinoma in situ loss of heterozygosity region on chromosome 8p22-p23 | journal = Genomics | volume = 60 | issue = 1 | pages = 1–11 | year = 1999 | pmid = 10458905 | doi = 10.1006/geno.1999.5905 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M |authorlink30=Huda Zoghbi| title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Wang JC, Radford DM, Holt MS, ''et al.'' |title=Sequence-ready contig for the 1.4-cM ductal carcinoma in situ loss of heterozygosity region on chromosome 8p22-p23. |journal=Genomics |volume=60 |issue= 1 |pages= 1-11 |year= 1999 |pmid= 10458905 |doi= 10.1006/geno.1999.5905 }}
*{{cite journal | author=Appel S, Reichwald K, Zimmermann W, ''et al.'' |title=Identification and localization of a new human myotubularin-related protein gene, mtmr8, on 8p22-p23. |journal=Genomics |volume=75 |issue= 1-3 |pages= 6-8 |year= 2001 |pmid= 11472061 |doi= 10.1006/geno.2001.6591 }}
*{{cite journal  | author=Appel S, Filter M, Reis A, ''et al.'' |title=Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759. |journal=Eur. J. Hum. Genet. |volume=10 |issue= 1 |pages= 17-25 |year= 2002 |pmid= 11896452 |doi= 10.1038/sj.ejhg.5200750 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Mochizuki Y, Majerus PW |title=Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 17 |pages= 9768-73 |year= 2003 |pmid= 12890864 |doi= 10.1073/pnas.1333958100 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Protein tyrosine phosphatases}}
{{WikiDoc Sources}}
 
 
{{gene-8-stub}}

Latest revision as of 15:14, 8 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Myotubularin-related protein 9 is a protein that in humans is encoded by the MTMR9 gene.[1][2][3][4]

Function

This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.[4]

Interactions

MTMR9 has been shown to interact with MTMR6.[3]

References

  1. ↑ Appel S, Reichwald K, Zimmermann W, Reis A, Rosenthal A, Hennies HC (Jul 2001). "Identification and localization of a new human myotubularin-related protein gene, mtmr8, on 8p22-p23". Genomics. 75 (1–3): 6–8. doi:10.1006/geno.2001.6591. PMID 11472061.
  2. ↑ Appel S, Filter M, Reis A, Hennies HC, Bergheim A, Ogilvie E, Arndt S, Simmons A, Lovett M, Hide W, Ramsay M, Reichwald K, Zimmermann W, Rosenthal A (Mar 2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759". Eur. J. Hum. Genet. 10 (1): 17–25. doi:10.1038/sj.ejhg.5200750. PMID 11896452.
  3. ↑ 3.0 3.1 Mochizuki Y, Majerus PW (Aug 2003). "Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9768–73. doi:10.1073/pnas.1333958100. PMC 187840. PMID 12890864.
  4. ↑ 4.0 4.1 "Entrez Gene: MTMR9 myotubularin related protein 9".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Wang JC, Radford DM, Holt MS, Helms C, Goate A, Brandt W, Parik M, Phillips NJ, DeSchryver K, Schuh ME, Fair KL, Ritter JH, Marshall P, Donis-Keller H (1999). "Sequence-ready contig for the 1.4-cM ductal carcinoma in situ loss of heterozygosity region on chromosome 8p22-p23". Genomics. 60 (1): 1–11. doi:10.1006/geno.1999.5905. PMID 10458905.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.


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