MFAP2

Microfibrillar-associated protein 2
Identifiers
Symbols	MFAP2 ; MAGP; MAGP-1; MAGP1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1801
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MFAP2 203417 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Microfibrillar-associated protein 2, also known as MFAP2, is a human gene.

Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. This gene encodes two transcripts with two alternatively spliced 5' untranslated exons. These two transcripts contain the same 8 coding exons, and therefore, encode the same protein.

Further reading

• Gibson MA, Hughes JL, Fanning JC, Cleary EG (1986). "The major antigen of elastin-associated microfibrils is a 31-kDa glycoprotein". J. Biol. Chem. 261 (24): 11429–36. PMID 3015971.CS1 maint: Multiple names: authors list (link)
• Faraco J, Bashir M, Rosenbloom J, Francke U (1995). "Characterization of the human gene for microfibril-associated glycoprotein (MFAP2), assignment to chromosome 1p36.1-p35, and linkage to D1S170". Genomics. 25 (3): 630–7. PMID 7759096.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Brown-Augsburger P, Broekelmann T, Rosenbloom J, Mecham RP (1996). "Functional domains on elastin and microfibril-associated glycoprotein involved in elastic fibre assembly". Biochem. J. 318 ( Pt 1): 149–55. PMID 8761465.CS1 maint: Multiple names: authors list (link)
• Finnis ML, Gibson MA (1997). "Microfibril-associated glycoprotein-1 (MAGP-1) binds to the pepsin-resistant domain of the alpha3(VI) chain of type VI collagen". J. Biol. Chem. 272 (36): 22817–23. PMID 9278443.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fujimoto N, Tajima S, Ishibashi A (2000). "Expression of microfibril-associated glycoprotein-1 (MAGP-1) in human epidermal keratinocytes". Arch. Dermatol. Res. 292 (1): 21–6. PMID 10664011.CS1 maint: Multiple names: authors list (link)
• Trask BC, Broekelmann T, Ritty TM; et al. (2001). "Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1)". Biochemistry. 40 (14): 4372–80. PMID 11284693.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jensen SA, Reinhardt DP, Gibson MA, Weiss AS (2001). "Protein interaction studies of MAGP-1 with tropoelastin and fibrillin-1". J. Biol. Chem. 276 (43): 39661–6. doi:10.1074/jbc.M104533200. PMID 11481325.CS1 maint: Multiple names: authors list (link)
• Reinboth B, Hanssen E, Cleary EG, Gibson MA (2002). "Molecular interactions of biglycan and decorin with elastic fiber components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1". J. Biol. Chem. 277 (6): 3950–7. doi:10.1074/jbc.M109540200. PMID 11723132.CS1 maint: Multiple names: authors list (link)
• Segade F, Trask BC, Broekelmann TJ; et al. (2002). "Identification of a matrix-binding domain in MAGP1 and MAGP2 and intracellular localization of alternative splice forms". J. Biol. Chem. 277 (13): 11050–7. doi:10.1074/jbc.M110347200. PMID 11796718.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Werneck CC, Trask BC, Broekelmann TJ; et al. (2004). "Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2". J. Biol. Chem. 279 (22): 23045–51. doi:10.1074/jbc.M402656200. PMID 15044481.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clarke AW, Weiss AS (2004). "Microfibril-associated glycoprotein-1 binding to tropoelastin: multiple binding sites and the role of divalent cations". Eur. J. Biochem. 271 (14): 3085–90. doi:10.1111/j.1432-1033.2004.04246.x. PMID 15233806.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyamoto A, Lau R, Hein PW; et al. (2006). "Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation". J. Biol. Chem. 281 (15): 10089–97. doi:10.1074/jbc.M600298200. PMID 16492672.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)