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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Mediator of RNA polymerase II transcription subunit 22''' is an [[enzyme]] that in humans is encoded by the ''MED22'' [[gene]].<ref name="pmid8499913">{{cite journal | vauthors = Yon J, Jones T, Garson K, Sheer D, Fried M | title = The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1 | journal = Human Molecular Genetics | volume = 2 | issue = 3 | pages = 237–40 | date = Mar 1993 | pmid = 8499913 | pmc =  | doi = 10.1093/hmg/2.3.237 }}</ref><ref name="pmid15175163">{{cite journal | vauthors = Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC | title = A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology | journal = Molecular Cell | volume = 14 | issue = 5 | pages = 685–91 | date = Jun 2004 | pmid = 15175163 | pmc = | doi = 10.1016/j.molcel.2004.05.006 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SURF5 surfeit 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6837| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Surfeit 5
| HGNCid = 11477
| Symbol = SURF5
| AltSymbols =; MED22; MED24; MGC48682
| OMIM = 185641
| ECnumber = 
| Homologene = 4913
| MGIid = 98446
| GeneAtlas_image1 = PBB_GE_SURF5_206593_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000119 |text = mediator complex}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6837
    | Hs_Ensembl = ENSG00000148297
    | Hs_RefseqProtein = NP_598395
    | Hs_RefseqmRNA = NM_133640
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 135194981
    | Hs_GenLoc_end = 135204793
    | Hs_Uniprot = Q15528
    | Mm_EntrezGene = 20933
    | Mm_Ensembl = ENSMUSG00000015776
    | Mm_RefseqmRNA = NM_001033908
    | Mm_RefseqProtein = NP_001029080
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 26727271
    | Mm_GenLoc_end = 26732686
    | Mm_Uniprot = Q3TTZ9
  }}
}}
'''Surfeit 5''', also known as '''SURF5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SURF5 surfeit 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6837| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is located in the [[surfeit]] gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SURF5 surfeit 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6837| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MED22 has been shown to [[Protein-protein interaction|interact]] with [[MED30]].<ref name=pmid12584197>{{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW | title = Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15123–7 | date = Apr 2003 | pmid = 12584197 | doi = 10.1074/jbc.C300054200 }}</ref>
{{refbegin | 2}}
 
{{PBB_Further_reading
== Model organisms ==
| citations =  
 
*{{cite journal | author=De Falco S, Russo G, Angiolillo A, Pietropaolo C |title=Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene. |journal=Gene |volume=126 |issue= 2 |pages= 227-35 |year= 1993 |pmid= 8482538 |doi=  }}
[[Model organism]]s have been used in the study of MED22 function. A conditional [[knockout mouse]] line called ''Med22<sup>tm1a(EUCOMM)Wtsi</sup>'' was generated at the [[Wellcome Trust Sanger Institute]].<ref name="mgp_reference">{{cite journal |url=http://onlinelibrary.wiley.com/doi/10.1111/j.1755-3768.2010.4142.x/abstract |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |doi=10.1111/j.1755-3768.2010.4142.x |volume=88 |journal=Acta Ophthalmologica}}</ref> Male and female animals underwent a standardized [[phenotypic screen]]<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Med22#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref> to determine the effects of deletion.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref><ref name="pmid23870131">{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | date = Jul 2013 | pmid = 23870131 | doi = 10.1016/j.cell.2013.06.022 | pmc=3717207}}</ref> Additional screens performed: - In-depth immunological phenotyping<ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=Med22&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref>
*{{cite journal | author=Yon J, Jones T, Garson K, ''et al.'' |title=The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1. |journal=Hum. Mol. Genet. |volume=2 |issue= 3 |pages= 237-40 |year= 1993 |pmid= 8499913 |doi= }}
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: left;" |
*{{cite journal | author=Garson K, Duhig T, Armes N, ''et al.'' |title=Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene. |journal=Genomics |volume=30 |issue= 2 |pages= 163-70 |year= 1996 |pmid= 8586415 |doi= 10.1006/geno.1995.9889 }}
|+ ''Med22'' knockout mouse phenotype
*{{cite journal | author=Garson K, Duhig T, Fried M |title=Tissue-specific processing of the Surf-5 and Surf-4 mRNAs. |journal=Gene Expr. |volume=6 |issue= 4 |pages= 209-18 |year= 1997 |pmid= 9196076 |doi=  }}
|-
*{{cite journal | author=Duhig T, Ruhrberg C, Mor O, Fried M |title=The human Surfeit locus. |journal=Genomics |volume=52 |issue= 1 |pages= 72-8 |year= 1999 |pmid= 9740673 |doi= 10.1006/geno.1998.5372 }}
! Characteristic!! Phenotype
*{{cite journal | author=Angiolillo A, Russo G, Porcellini A, ''et al.'' |title=The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts. |journal=Gene |volume=284 |issue= 1-2 |pages= 169-78 |year= 2002 |pmid= 11891058 |doi= }}
|-
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
| colspan=2; style="text-align: center;" | All data available at.<ref name="IMPCsearch_ref"/><ref name="iii_ref" />
*{{cite journal | author=Sato S, Tomomori-Sato C, Banks CA, ''et al.'' |title=Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15123-7 |year= 2003 |pmid= 12584197 |doi= 10.1074/jbc.C300054200 }}
|-
*{{cite journal | author=Sato S, Tomomori-Sato C, Banks CA, ''et al.'' |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671-4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 }}
| Insulin || bgcolor="#488ED3"|Normal
*{{cite journal | author=Tomomori-Sato C, Sato S, Parmely TJ, ''et al.'' |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846-51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 }}
 
*{{cite journal | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 }}
|-
*{{cite journal  | author=Sato S, Tomomori-Sato C, Parmely TJ, ''et al.'' |title=A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. |journal=Mol. Cell |volume=14 |issue= 5 |pages= 685-91 |year= 2004 |pmid= 15175163 |doi= 10.1016/j.molcel.2004.05.006 }}
| Homozygous viability at P14 || bgcolor="#C40000"|Abnormal
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
 
}}
|-
| [[Recessive]] lethal study || bgcolor="#C40000"|Abnormal
 
|-
| Body weight || bgcolor="#488ED3"|Normal
 
|-
| Neurological assessment || bgcolor="#488ED3"|Normal
 
|-
| Grip strength || bgcolor="#488ED3"|Normal
 
|-
| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
 
|-
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
 
|-
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
 
|-
| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
 
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#C40000"|Abnormal
 
|-
| [[Radiography]] || bgcolor="#488ED3"|Normal
 
|-
| Eye morphology || bgcolor="#488ED3"|Normal
 
|-
| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
 
|-
| ''[[Haematology]]'' 16 Weeks || bgcolor="#488ED3"|Normal
 
|-
| Peripheral blood leukocytes 16 Weeks || bgcolor="#488ED3"|Normal
 
|-
| [[Micronucleus test]] || bgcolor="#C40000"|Abnormal
 
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal
 
|-
|}
{{clear}}
 
== References ==
{{reflist|33em}}
 
== Further reading ==
{{refbegin|33em}}
* {{cite journal | vauthors = De Falco S, Russo G, Angiolillo A, Pietropaolo C | title = Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene | journal = Gene | volume = 126 | issue = 2 | pages = 227–35 | date = Apr 1993 | pmid = 8482538 | doi = 10.1016/0378-1119(93)90371-9 }}
* {{cite journal | vauthors = Garson K, Duhig T, Armes N, Colombo P, Fried M | title = Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene | journal = Genomics | volume = 30 | issue = 2 | pages = 163–70 | date = Nov 1995 | pmid = 8586415 | doi = 10.1006/geno.1995.9889 }}
* {{cite journal | vauthors = Garson K, Duhig T, Fried M | title = Tissue-specific processing of the Surf-5 and Surf-4 mRNAs | journal = Gene Expression | volume = 6 | issue = 4 | pages = 209–18 | year = 1997 | pmid = 9196076 | doi =  }}
* {{cite journal | vauthors = Duhig T, Ruhrberg C, Mor O, Fried M | title = The human Surfeit locus | journal = Genomics | volume = 52 | issue = 1 | pages = 72–8 | date = Aug 1998 | pmid = 9740673 | doi = 10.1006/geno.1998.5372 }}
* {{cite journal | vauthors = Angiolillo A, Russo G, Porcellini A, Smaldone S, D'Alessandro F, Pietropaolo C | title = The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts | journal = Gene | volume = 284 | issue = 1-2 | pages = 169–78 | date = Feb 2002 | pmid = 11891058 | doi = 10.1016/S0378-1119(02)00379-7 }}
* {{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW | title = Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15123–7 | date = Apr 2003 | pmid = 12584197 | doi = 10.1074/jbc.C300054200 }}
* {{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW | title = A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 49671–4 | date = Dec 2003 | pmid = 14576168 | doi = 10.1074/jbc.C300444200 }}
* {{cite journal | vauthors = Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5846–51 | date = Feb 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 }}
* {{cite journal | vauthors = Hillman RT, Green RE, Brenner SE | title = An unappreciated role for RNA surveillance | journal = Genome Biology | volume = 5 | issue = 2 | pages = R8 | year = 2005 | pmid = 14759258 | pmc = 395752 | doi = 10.1186/gb-2004-5-2-r8 }}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-9-stub}}

Revision as of 02:42, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mediator of RNA polymerase II transcription subunit 22 is an enzyme that in humans is encoded by the MED22 gene.[1][2][3]

Function

This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.[3]

Interactions

MED22 has been shown to interact with MED30.[4]

Model organisms

Model organisms have been used in the study of MED22 function. A conditional knockout mouse line called Med22tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[5] Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11]

References

  1. ↑ Yon J, Jones T, Garson K, Sheer D, Fried M (Mar 1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Human Molecular Genetics. 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID 8499913.
  2. ↑ Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
  3. ↑ 3.0 3.1 "Entrez Gene: SURF5 surfeit 5".
  4. ↑ Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW (Apr 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
  5. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88. doi:10.1111/j.1755-3768.2010.4142.x.
  6. ↑ 6.0 6.1 "International Mouse Phenotyping Consortium".
  7. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  8. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  9. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  10. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  11. ↑ 11.0 11.1 "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

  • De Falco S, Russo G, Angiolillo A, Pietropaolo C (Apr 1993). "Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene". Gene. 126 (2): 227–35. doi:10.1016/0378-1119(93)90371-9. PMID 8482538.
  • Garson K, Duhig T, Armes N, Colombo P, Fried M (Nov 1995). "Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene". Genomics. 30 (2): 163–70. doi:10.1006/geno.1995.9889. PMID 8586415.
  • Garson K, Duhig T, Fried M (1997). "Tissue-specific processing of the Surf-5 and Surf-4 mRNAs". Gene Expression. 6 (4): 209–18. PMID 9196076.
  • Duhig T, Ruhrberg C, Mor O, Fried M (Aug 1998). "The human Surfeit locus". Genomics. 52 (1): 72–8. doi:10.1006/geno.1998.5372. PMID 9740673.
  • Angiolillo A, Russo G, Porcellini A, Smaldone S, D'Alessandro F, Pietropaolo C (Feb 2002). "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts". Gene. 284 (1–2): 169–78. doi:10.1016/S0378-1119(02)00379-7. PMID 11891058.
  • Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW (Apr 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
  • Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW (Dec 2003). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex". The Journal of Biological Chemistry. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
  • Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
  • Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.


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