MAP3K10

Mitogen-activated protein kinase kinase kinase 10
Identifiers
Symbols	MAP3K10 ; MLK2; MST
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1834
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MAP3K10 206362 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Mitogen-activated protein kinase kinase kinase 10, also known as MAP3K10, is a human gene.

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.

Further reading

• Katoh M, Hirai M, Sugimura T, Terada M (1995). "Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain". Oncogene. 10 (7): 1447–51. PMID 7731697.CS1 maint: Multiple names: authors list (link)
• Gallo KA, Mark MR, Scadden DT; et al. (1994). "Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity". J. Biol. Chem. 269 (21): 15092–100. PMID 8195146.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dorow DS, Devereux L, Dietzsch E, De Kretser T (1993). "Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains". Eur. J. Biochem. 213 (2): 701–10. PMID 8477742.CS1 maint: Multiple names: authors list (link)
• Dorow DS, Devereux L, Tu GF; et al. (1996). "Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2". Eur. J. Biochem. 234 (2): 492–500. PMID 8536694.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirai S, Katoh M, Terada M; et al. (1997). "MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase". J. Biol. Chem. 272 (24): 15167–73. PMID 9182538.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagata K, Puls A, Futter C; et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. doi:10.1093/emboj/17.1.149. PMID 9427749.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirai S, Noda K, Moriguchi T; et al. (1998). "Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2". J. Biol. Chem. 273 (13): 7406–12. PMID 9516438.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rasmussen RK, Ji H, Eddes JS; et al. (1998). "Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins". Electrophoresis. 19 (5): 809–17. doi:10.1002/elps.1150190535. PMID 9629920.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rasmussen RK, Rusak J, Price G; et al. (1998). "Mixed-lineage kinase 2-SH3 domain binds dynamin and greatly enhances activation of GTPase by phospholipid". Biochem. J. 335 ( Pt 1): 119–24. PMID 9742220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu YF, Dorow D, Marshall J (2000). "Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin". J. Biol. Chem. 275 (25): 19035–40. doi:10.1074/jbc.C000180200. PMID 10801775.CS1 maint: Multiple names: authors list (link)
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMID 11076863.CS1 maint: Multiple names: authors list (link)
• Savinainen A, Garcia EP, Dorow D; et al. (2001). "Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95". J. Biol. Chem. 276 (14): 11382–6. doi:10.1074/jbc.M100190200. PMID 11152698.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu Z, Maroney AC, Dobrzanski P; et al. (2001). "The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis". Mol. Cell. Biol. 21 (14): 4713–24. doi:10.1128/MCB.21.14.4713-4724.2001. PMID 11416147.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Poy MN, Yang Y, Rezaei K; et al. (2002). "CEACAM1 regulates insulin clearance in liver". Nat. Genet. 30 (3): 270–6. doi:10.1038/ng840. PMID 11850617.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akbarzadeh S, Ji H, Frecklington D; et al. (2002). "Mixed lineage kinase 2 interacts with clathrin and influences clathrin-coated vesicle trafficking". J. Biol. Chem. 277 (39): 36280–7. doi:10.1074/jbc.M204626200. PMID 12105200.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Figueroa C, Tarras S, Taylor J, Vojtek AB (2004). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284.CS1 maint: Multiple names: authors list (link)
• Eckey M, Tenbaum SP, Muñoz A, Baniahmad A (2004). "Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors". Mol. Cell. Endocrinol. 213 (1): 71–8. doi:10.1016/j.mce.2003.10.035. PMID 15062575.CS1 maint: Multiple names: authors list (link)
• Jaffe AB, Hall A, Schmidt A (2005). "Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho". Curr. Biol. 15 (5): 405–12. doi:10.1016/j.cub.2004.12.082. PMID 15753034.CS1 maint: Multiple names: authors list (link)
• Kollers S, Musilova P, Rubes J, Rocha D (2007). "Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13". Anim. Genet. 37 (6): 595–6. doi:10.1111/j.1365-2052.2006.01516.x. PMID 17121608.CS1 maint: Multiple names: authors list (link)