Lyme disease natural history, complications and prognosis: Difference between revisions

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==Overview==
==Overview==
==Prognosis==
For early cases, prompt treatment is usually curative.<ref>{{cite journal |author=Krause PJ, Foley DT, Burke GS, Christianson D, Closter L, Spielman A |title=Reinfection and relapse in early Lyme disease |journal=Am. J. Trop. Med. Hyg. |volume=75 |issue=6 |pages=1090-4 |year=2006 |pmid=17172372}}</ref> However, the severity and treatment of Lyme disease may be complicated due to late diagnosis, failure of antibiotic treatment, simultaneous infection with other tick-borne diseases including [[ehrlichiosis]], [[babesiosis]], and [[bartonella]], and immune suppression in the patient.
A meta-analysis published in 2005 found that some patients with Lyme disease have fatigue, joint and/or muscle pain, and [[neurocognitive]] symptoms persisting for years despite antibiotic treatment.<ref name="Cairns">{{cite journal | author = Cairns V, Godwin J | title = Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms. | journal = Int J Epidemiol | volume = 34 | issue = 6 | pages = 1340-5 | year = 2005 | pmid = 16040645}}</ref> Patients with late Stage Lyme disease have been shown to experience a level of physical [[disability]] equivalent to that seen in [[congestive heart failure]].<ref name="Klempner">{{cite journal | author=Klempner MS, Hu LT, Evans J, ''et al'' | title=Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease | journal=N Engl J Med | year=2001 | pages=85-92 | volume=345 | issue=2 | pmid= 11450676}}</ref>
Though rare, Lyme disease can be fatal.<ref name="Kirsch">{{cite journal | author=Kirsch M, Ruben FL, Steere AC, Duray PH, Norden CW, Winkelstein A | title=Fatal adult respiratory distress syndrome in a patient with Lyme disease | journal=JAMA | year=1988 | pages=2737-9 | volume=259 | issue=18 | pmid= 3357244}}</ref><ref name="Oksi-b">{{cite journal | author=Oksi J, Kalimo H, Marttila RJ, ''et al'' | title=Inflammatory brain changes in Lyme borreliosis. A report on three patients and review of literature | journal=Brain | year=1996 | pages=2143-54 | volume=119 | issue=Pt 6 | pmid= 9010017}}</ref><ref name="Waniek">{{cite journal | author=Waniek C, Prohovnik I, Kaufman MA, Dwork AJ | title=Rapidly progressive frontal-type dementia associated with Lyme disease | journal=J Neuropsychiatry Clin Neurosci | year=1995 | pages=345-7 | volume=7 | issue=3 | pmid= 7580195}}</ref><ref name="Cary">{{cite journal | author=Cary NR, Fox B, Wright DJ, Cutler SJ, Shapiro LM, Grace AA | title=Fatal Lyme carditis and endodermal heterotopia of the atrioventricular node | journal=Postgrad Med J | year=1990 | pages=134-6 | volume=66 | issue=772 | pmid= 2349186}}</ref>The first CDC recognized death from Lyme disease was Amanda Schmidt, age 11.<ref>{{ cite news | url = http://pqasb.pqarchiver.com/latimes/access/60144819.html?dids=60144819:60144819&FMT=ABS&FMTS=ABS:FT&type=current&date=Sep+26%2C+1990&author=&pub=Los+Angeles+Times+(pre-1997+Fulltext)&edition=&startpage=2&desc=HEALTH+First+Lyme+Disease+Death+Told | title = First Lyme Disease Death Told | work = Los Angeles Times | date = 1990-09-26}}</ref><!-- Need better ref, here -->


==References==
==References==

Revision as of 19:31, 8 February 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Prognosis

For early cases, prompt treatment is usually curative.[1] However, the severity and treatment of Lyme disease may be complicated due to late diagnosis, failure of antibiotic treatment, simultaneous infection with other tick-borne diseases including ehrlichiosis, babesiosis, and bartonella, and immune suppression in the patient.

A meta-analysis published in 2005 found that some patients with Lyme disease have fatigue, joint and/or muscle pain, and neurocognitive symptoms persisting for years despite antibiotic treatment.[2] Patients with late Stage Lyme disease have been shown to experience a level of physical disability equivalent to that seen in congestive heart failure.[3]

Though rare, Lyme disease can be fatal.[4][5][6][7]The first CDC recognized death from Lyme disease was Amanda Schmidt, age 11.[8]

References

  1. Krause PJ, Foley DT, Burke GS, Christianson D, Closter L, Spielman A (2006). "Reinfection and relapse in early Lyme disease". Am. J. Trop. Med. Hyg. 75 (6): 1090–4. PMID 17172372.
  2. Cairns V, Godwin J (2005). "Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms". Int J Epidemiol. 34 (6): 1340–5. PMID 16040645.
  3. Klempner MS, Hu LT, Evans J; et al. (2001). "Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease". N Engl J Med. 345 (2): 85–92. PMID 11450676.
  4. Kirsch M, Ruben FL, Steere AC, Duray PH, Norden CW, Winkelstein A (1988). "Fatal adult respiratory distress syndrome in a patient with Lyme disease". JAMA. 259 (18): 2737–9. PMID 3357244.
  5. Oksi J, Kalimo H, Marttila RJ; et al. (1996). "Inflammatory brain changes in Lyme borreliosis. A report on three patients and review of literature". Brain. 119 (Pt 6): 2143–54. PMID 9010017.
  6. Waniek C, Prohovnik I, Kaufman MA, Dwork AJ (1995). "Rapidly progressive frontal-type dementia associated with Lyme disease". J Neuropsychiatry Clin Neurosci. 7 (3): 345–7. PMID 7580195.
  7. Cary NR, Fox B, Wright DJ, Cutler SJ, Shapiro LM, Grace AA (1990). "Fatal Lyme carditis and endodermal heterotopia of the atrioventricular node". Postgrad Med J. 66 (772): 134–6. PMID 2349186.
  8. "First Lyme Disease Death Told". Los Angeles Times. 1990-09-26.


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