Lipoid pneumonia natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
Patients might present acutely with [[inflammation]] and [[cough]], [[fever]], and [[dyspnea]]. However, they might be [[asymptomatic]] and present with an incidental mass on radiographs. | Patients might present acutely with [[inflammation]] and [[cough]], [[fever]], and [[dyspnea]]. However, they might be [[asymptomatic]] and present with an incidental mass on radiographs. Due to its nonspecific symptoms and radiological features, lipoid pneumonia often remains undiagnosed or diagnosis is delayed. The oil released illicits a giant-cell [[Granulomatous|granulomatous reaction]] (hence also called lipid [[granulomatosis]]), [[chronic inflammation]], and alveolar and [[interstitial fibrosis]]. Evolution of lesions with time has been described: Fresh lesions show alveolar infiltration by [[Macrophage|lipid-laden macrophages]] and almost normal [[Alveolus|alveolar]] walls and septa, and advanced lesions show larger [[vacuoles]] and [[Inflammation|inflammatory infiltrates]] in alveolar walls, bronchial walls and septa. | ||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
*Patients might present acutely with [[inflammation]] and [[cough]], [[fever]], and [[dyspnea]]. However, they might be [[asymptomatic]] and present with an incidental mass on radiographs.<ref name="GuerguerianLacroix2000">{{cite journal|last1=Guerguerian|first1=Anne-Marie|last2=Lacroix|first2=Jacques|title=Pulmonary injury after intravenous hydrocarbon injection|journal=Paediatrics & Child Health|volume=5|issue=8|year=2000|pages=471–472|issn=1205-7088|doi=10.1093/pch/5.8.471}}</ref><ref name="DomejMitterhammer2007">{{cite journal|last1=Domej|first1=Wolfgang|last2=Mitterhammer|first2=Heike|last3=Stauber|first3=Rudolf|last4=Kaufmann|first4=Peter|last5=Smolle|first5=Karl Heinz|title=Successful outcome after intravenous gasoline injection|journal=Journal of Medical Toxicology|volume=3|issue=4|year=2007|pages=173–177|issn=1556-9039|doi=10.1007/BF03160935}}</ref> | *Patients might present acutely with [[inflammation]] and [[cough]], [[fever]], and [[dyspnea]]. However, they might be [[asymptomatic]] and present with an incidental mass on radiographs.<ref name="GuerguerianLacroix2000">{{cite journal|last1=Guerguerian|first1=Anne-Marie|last2=Lacroix|first2=Jacques|title=Pulmonary injury after intravenous hydrocarbon injection|journal=Paediatrics & Child Health|volume=5|issue=8|year=2000|pages=471–472|issn=1205-7088|doi=10.1093/pch/5.8.471}}</ref><ref name="DomejMitterhammer2007">{{cite journal|last1=Domej|first1=Wolfgang|last2=Mitterhammer|first2=Heike|last3=Stauber|first3=Rudolf|last4=Kaufmann|first4=Peter|last5=Smolle|first5=Karl Heinz|title=Successful outcome after intravenous gasoline injection|journal=Journal of Medical Toxicology|volume=3|issue=4|year=2007|pages=173–177|issn=1556-9039|doi=10.1007/BF03160935}}</ref> | ||
* | *Due to its nonspecific symptoms and radiological features, lipoid pneumonia often remains undiagnosed or diagnosis is delayed. | ||
*The oil released illicits a giant-cell granulomatous reaction (hence also called lipid granulomatosis), chronic inflammation, and alveolar and interstitial fibrosis | *The oil released illicits a giant-cell [[Granulomatous|granulomatous reaction]] (hence also called lipid [[granulomatosis]]), [[chronic inflammation]], and alveolar and [[interstitial fibrosis]]. | ||
*Evolution of lesions with time has been described:<ref name="BurkeFraser1988">{{cite journal|last1=Burke|first1=M|last2=Fraser|first2=R|title=Obstructive pneumonitis: a pathologic and pathogenetic reappraisal.|journal=Radiology|volume=166|issue=3|year=1988|pages=699–704|issn=0033-8419|doi=10.1148/radiology.166.3.3340764}}</ref><ref name="urlwww.thoracic.org">{{cite web |url=https://www.thoracic.org/statements/resources/interstitial-lung-disease/online-supplement-clinical-utility-blcaild.pdf |title=www.thoracic.org |format= |work= |accessdate=}}</ref><ref name="CohenCline1972">{{cite journal|last1=Cohen|first1=Allen B.|last2=Cline|first2=Martin J.|title=In VitroStudies of the Foamy Macrophage of Postobstructive Endogenous Lipoid Pneumonia in Man1–3|journal=American Review of Respiratory Disease|volume=106|issue=1|year=1972|pages=69–78|issn=0003-0805|doi=10.1164/arrd.1972.106.1.69}}</ref> | *Evolution of lesions with time has been described:<ref name="BurkeFraser1988">{{cite journal|last1=Burke|first1=M|last2=Fraser|first2=R|title=Obstructive pneumonitis: a pathologic and pathogenetic reappraisal.|journal=Radiology|volume=166|issue=3|year=1988|pages=699–704|issn=0033-8419|doi=10.1148/radiology.166.3.3340764}}</ref><ref name="urlwww.thoracic.org">{{cite web |url=https://www.thoracic.org/statements/resources/interstitial-lung-disease/online-supplement-clinical-utility-blcaild.pdf |title=www.thoracic.org |format= |work= |accessdate=}}</ref><ref name="CohenCline1972">{{cite journal|last1=Cohen|first1=Allen B.|last2=Cline|first2=Martin J.|title=In VitroStudies of the Foamy Macrophage of Postobstructive Endogenous Lipoid Pneumonia in Man1–3|journal=American Review of Respiratory Disease|volume=106|issue=1|year=1972|pages=69–78|issn=0003-0805|doi=10.1164/arrd.1972.106.1.69}}</ref> | ||
**Fresh lesions show alveolar infiltration by lipid-laden macrophages and almost normal alveolar walls and septa | **Fresh lesions show alveolar infiltration by lipid-laden macrophages and almost normal alveolar walls and septa. | ||
**Advanced lesions show larger vacuoles and inflammatory infiltrates in alveolar walls, bronchial walls and septa | **Advanced lesions show larger vacuoles and inflammatory infiltrates in alveolar walls, bronchial walls and septa. | ||
==References== | ==References== | ||
Latest revision as of 00:21, 30 October 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
Patients might present acutely with inflammation and cough, fever, and dyspnea. However, they might be asymptomatic and present with an incidental mass on radiographs. Due to its nonspecific symptoms and radiological features, lipoid pneumonia often remains undiagnosed or diagnosis is delayed. The oil released illicits a giant-cell granulomatous reaction (hence also called lipid granulomatosis), chronic inflammation, and alveolar and interstitial fibrosis. Evolution of lesions with time has been described: Fresh lesions show alveolar infiltration by lipid-laden macrophages and almost normal alveolar walls and septa, and advanced lesions show larger vacuoles and inflammatory infiltrates in alveolar walls, bronchial walls and septa.
Natural History, Complications, and Prognosis
- Patients might present acutely with inflammation and cough, fever, and dyspnea. However, they might be asymptomatic and present with an incidental mass on radiographs.[1][2]
- Due to its nonspecific symptoms and radiological features, lipoid pneumonia often remains undiagnosed or diagnosis is delayed.
- The oil released illicits a giant-cell granulomatous reaction (hence also called lipid granulomatosis), chronic inflammation, and alveolar and interstitial fibrosis.
- Evolution of lesions with time has been described:[3][4][5]
- Fresh lesions show alveolar infiltration by lipid-laden macrophages and almost normal alveolar walls and septa.
- Advanced lesions show larger vacuoles and inflammatory infiltrates in alveolar walls, bronchial walls and septa.
References
- ↑ Guerguerian, Anne-Marie; Lacroix, Jacques (2000). "Pulmonary injury after intravenous hydrocarbon injection". Paediatrics & Child Health. 5 (8): 471–472. doi:10.1093/pch/5.8.471. ISSN 1205-7088.
- ↑ Domej, Wolfgang; Mitterhammer, Heike; Stauber, Rudolf; Kaufmann, Peter; Smolle, Karl Heinz (2007). "Successful outcome after intravenous gasoline injection". Journal of Medical Toxicology. 3 (4): 173–177. doi:10.1007/BF03160935. ISSN 1556-9039.
- ↑ Burke, M; Fraser, R (1988). "Obstructive pneumonitis: a pathologic and pathogenetic reappraisal". Radiology. 166 (3): 699–704. doi:10.1148/radiology.166.3.3340764. ISSN 0033-8419.
- ↑ "www.thoracic.org" (PDF).
- ↑ Cohen, Allen B.; Cline, Martin J. (1972). "In VitroStudies of the Foamy Macrophage of Postobstructive Endogenous Lipoid Pneumonia in Man1–3". American Review of Respiratory Disease. 106 (1): 69–78. doi:10.1164/arrd.1972.106.1.69. ISSN 0003-0805.