Leiomyosarcoma surgery: Difference between revisions

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{{Leiomyosarcoma}}
{{Leiomyosarcoma}}
{{CMG}}
{{CMG}}{{AE}} {{Nnasiri}}


==Overview==
==Overview==
Patients with leiomyosarcoma have many treatment options. The selection depends on the stage of the tumor. The options are surgery, radiation therapy, chemotherapy, or a combination of these methods. Before treatment starts, ask your health care team about possible side effects and how treatment may change your normal activities. Because cancer treatments often damage healthy cells and tissues, side effects are common. Side effects may not be the same for each person, and they may change from one treatment session to the next.
Patients with [[leiomyosarcoma]] have many treatment options but [[surgery]] is considered the mainstay of treatment for all soft tissue [[sarcoma]]<nowiki/>s. The selection depends on the stage of the tumor. The options are [[surgery]], [[radiation therapy]], [[chemotherapy]], or a combination of these methods. Treatment options are not chosen by the histological subtype of [[sarcoma]] but by tumor grade, size, and location of primary or [[metastatic]] disease.


==Surgery==
==Surgery==
*'''Surgery:''' Generally, Surgery has been the main effective way of treating the leiomyosarcoma,regardless of the location of the tumor in the body. The goal of surgery is to remove the tumor and some surrounding tissue to cure leiomyosarcoma and to prevent the local recurrence.Lymphadenectomy is generally not required as the tumor usually metastasize hematogenously and rarely through the lymph nodes.
* [[Surgery]] is mainstay of therapy in leiomyosarcoma patients, in case of recurrence or progression of disease combination therapy with chemoradiation can be used as well. <ref name="pmid17338203">{{cite journal |vauthors=Vrzic-Petronijevic S, Likic-Ladjevic I, Petronijevic M, Argirovic R, Ladjevic N |title=Diagnosis and surgical therapy of uterine sarcoma |journal=Acta Chir Iugosl |volume=53 |issue=3 |pages=67–72 |date=2006 |pmid=17338203 |doi= |url=}}</ref>
* [[Surgical]] resection of local recurrence and [[pulmonary]] [[metastases]] should be considered in individual patients.<ref name="GrimerJudson2010">{{cite journal|last1=Grimer|first1=Robert|last2=Judson|first2=Ian|last3=Peake|first3=David|last4=Seddon|first4=Beatrice|title=Guidelines for the Management of Soft Tissue Sarcomas|journal=Sarcoma|volume=2010|year=2010|pages=1–15|issn=1357-714X|doi=10.1155/2010/506182}}</ref>
* [[Hysterectomy]] with bilateral [[salpingoophorectomy]] has been the main effective way of [[surgical]] therapy in patients with leiomyosarcoma.<ref name="urlTreatment for Uterine Sarcoma, by Type and Stage">{{cite web |url=https://www.cancer.org/cancer/uterine-sarcoma/treating/by-stage.html |title=Treatment for Uterine Sarcoma, by Type and Stage |format= |work= |accessdate=}}</ref>
* [[Lymphadenectomy]] is generally not required as the [[tumor]] usually [[metastasize]] hematogenously and rarely through the [[lymph nodes]].<ref name="pmid18506484">Park JY, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT et al. (2008) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18506484 Prognostic factors and treatment outcomes of patients with uterine sarcoma: analysis of 127 patients at a single institution, 1989-2007.] ''J Cancer Res Clin Oncol'' 134 (12):1277-87. [http://dx.doi.org/10.1007/s00432-008-0422-2 DOI:10.1007/s00432-008-0422-2] PMID: [https://pubmed.gov/18506484 18506484]</ref><ref name="pmid14529683">Leitao MM, Sonoda Y, Brennan MF, Barakat RR, Chi DS (2003) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=14529683 Incidence of lymph node and ovarian metastases in leiomyosarcoma of the uterus.] ''Gynecol Oncol'' 91 (1):209-12. PMID: [https://pubmed.gov/14529683 14529683]</ref><ref name="urlUterine Sarcoma Stages">{{cite web |url=https://www.cancer.org/cancer/uterine-sarcoma/detection-diagnosis-staging/staging.html |title=Uterine Sarcoma Stages |format= |work= |accessdate=}}</ref>
 
 
 
{{Family tree/start}}
{{Family tree | | | | | | | B01 | | | |B01=[[Established stage]] based on the result of physical exam, imaging and biopsy}}
{{Family tree | | |,|-|-|v|-|^|-|v|-|-|-|.| | }}
{{Family tree | | C01 | | C02 | | C03 | | C04 | |C01=Stage 1 <br>low grade tumors|C02=Stage 2<br>less than 5 cm<br>high grade tumor|C03=Stage 3<br>more than 5 cm<br>high grade tumor or nodal disease|C04=Stage 4<br>distant metastasis}}
{{Family tree | | |!| | | |!| | | |!| | | |!| | | |}}
{{Family tree | | D01 | |D02| | D03 | | D04 | |D01=Surgical resection|D02=surgical resection<br>with or without radiation|D03=surgical resection with radiation<br>with or without chemotherapy|D04=chemotherapy<br>with or without surgical resection}}
{{Family tree/end}}


==References==
==References==

Latest revision as of 13:54, 19 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]

Overview

Patients with leiomyosarcoma have many treatment options but surgery is considered the mainstay of treatment for all soft tissue sarcomas. The selection depends on the stage of the tumor. The options are surgery, radiation therapy, chemotherapy, or a combination of these methods. Treatment options are not chosen by the histological subtype of sarcoma but by tumor grade, size, and location of primary or metastatic disease.

Surgery


 
 
 
 
 
 
Established stage based on the result of physical exam, imaging and biopsy
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Stage 1
low grade tumors
 
Stage 2
less than 5 cm
high grade tumor
 
Stage 3
more than 5 cm
high grade tumor or nodal disease
 
Stage 4
distant metastasis
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Surgical resection
 
surgical resection
with or without radiation
 
surgical resection with radiation
with or without chemotherapy
 
chemotherapy
with or without surgical resection
 

References

  1. Vrzic-Petronijevic S, Likic-Ladjevic I, Petronijevic M, Argirovic R, Ladjevic N (2006). "Diagnosis and surgical therapy of uterine sarcoma". Acta Chir Iugosl. 53 (3): 67–72. PMID 17338203.
  2. Grimer, Robert; Judson, Ian; Peake, David; Seddon, Beatrice (2010). "Guidelines for the Management of Soft Tissue Sarcomas". Sarcoma. 2010: 1–15. doi:10.1155/2010/506182. ISSN 1357-714X.
  3. "Treatment for Uterine Sarcoma, by Type and Stage".
  4. Park JY, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT et al. (2008) Prognostic factors and treatment outcomes of patients with uterine sarcoma: analysis of 127 patients at a single institution, 1989-2007. J Cancer Res Clin Oncol 134 (12):1277-87. DOI:10.1007/s00432-008-0422-2 PMID: 18506484
  5. Leitao MM, Sonoda Y, Brennan MF, Barakat RR, Chi DS (2003) Incidence of lymph node and ovarian metastases in leiomyosarcoma of the uterus. Gynecol Oncol 91 (1):209-12. PMID: 14529683
  6. "Uterine Sarcoma Stages".


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