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==Overview==
==Overview==
'''Labetalol''' ('''Normodyne''', '''Trandate''', fixed combination with [[hydrochlorothiazide]]: '''Normozyde''') is an [[alpha blocker|alpha-1]] and[[beta blocker|beta adrenergic blocker]] used to treat [[hypertension|high blood pressure]].  It works by blocking these adrenergic receptors, which slows sinus [[heart]] rate, decreases peripheral vascular resistance.
'''Labetalol''' ('''Normodyne''', '''Trandate''', fixed combination with [[hydrochlorothiazide]]: '''Normozyde''') is an [[alpha blocker|alpha-1]] and[[beta blocker|beta adrenergic blocker]] used to treat [[hypertension|high blood pressure]].  It works by blocking these adrenergic receptors, which slows sinus [[heart]] rate, decreases peripheral vascular resistance.


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[[Category:Cardiovascular Drugs]]
[[Category:Cardiovascular Drugs]]
[[Category:Drugs]]
[[Category:Drugs]]
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{{drugbox
| IUPAC_name = 2-hydroxy-5-[1-hydroxy-2-<br>(4-phenylbutan-2-ylamino)-ethyl]-benzamide
| image = Labetalol_svg.png
| CAS_number = 36894-69-6
| ATC_prefix = C07
| ATC_suffix = AG01
| PubChem = 3869
| DrugBank = APRD01062
| C = 19 |H = 24 |N = 2 |O = 3
| molecular_weight = 328.406 [[Gram|g]]/[[Mole (unit)|mol]]
| bioavailability = 90-100%
| protein_bound = 50%
| metabolism = [[hepatic]] pass metabolism,
| elimination_half-life = Tablet: 6-8 hours; IV: 5.5 hours
| pregnancy_category = C<br>One of few drugs used for [[pregnancy-induced hypertension|PIH]]
| legal_status = Rx-only
| routes_of_administration = oral [[intravenous|iv]]
| excretion = Excreted in urine, not removed by hemodialysis
}}
__NOTOC__
{{CMG}}
==Overview==
'''Labetalol''' ('''Normodyne''', '''Trandate''', fixed combination with [[hydrochlorothiazide]]: '''Normozyde''') is an [[alpha blocker|alpha-1]] and [[beta blocker|beta adrenergic blocker]] used to treat [[hypertension|high blood pressure]].  It works by blocking these adrenergic receptors, which slows sinus [[heart]] rate, decreases peripheral vascular resistance.
It has a particular indication in the treatment of [[pregnancy-induced hypertension]].
==Administration==
Labetalol is available in 100, 200, and 300 mg tablets and [[intravenous|intravenously]] (only as '''Trandate''') in 5 mg/ml solution.  Adults taking tablets usually start with 100 mg two times a day, with a maximum of 2.4 g/day.  In an emergency situation, this may be higher.  IV doses are usually started at 20mg over 2 minutes.  Additional doses of 40mg, then 80mg may be administered every ten minutes as needed.  Additional 80mg doses can be given to a total maximum dose of 300 mg.  Additionally, Labetalol can be administered by IV infusion at a rate of 2mg/minute, with a maximum dose of 300mg.
==Side effects==
Side effects may include:
* [[Somnolence|Drowsiness]]
* [[Fatigue (physical)|Fatigue]]
* [[Weakness (medical)|Weakness]]
* [[Insomnia|Difficulty sleeping]]
* [[Sexual dysfunction|Diminished sexual function]]
* Scalp tingling which passes after time.
* A rare but potentially lethal side effect is respiratory distress. If respiratory distress occurs after starting this drug, do not take additional dose; go to the emergency room and tell the clinician that you are having respiratory distress that you think may be due to the labetalol.  Nurses: If your hospitalized patient on labetalol begins to have respiratory distress (may have no decrease in oximetry readings), stop the drug, initiate oxygen at 1-2 liters, and call the physician. Closely monitor the patient until all signs of respiratory distress are relieved.
==Contraindications==
Labetalol should not be used in patients that have asthma, congestive heart failure, any degree of heart blocks, slow heart rates or those in cardiogenic shock
==References==
*Hodgson, Barbara B., and Kizior, Robert J.  ''Saunders Nursing Drug Handbook 2006''.  St. Louis, MO: Elsevier, Saunders, 2006. bledsoe  "prehospital emergency pharmacology"  upper Saddle River, New Jersey: Pearson 2005
{{beta blockers}}
[[Category:Beta blockers]]
[[Category:Drugs]]
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Revision as of 18:53, 4 February 2014

Labetalol
LABETALOL tablet® FDA Package Insert
Indications and Usage
Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
LABETALOL injection® FDA Package Insert
Indications and Usage
Dosage and Administration
Dosage Forms and Strengths
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Overdosage
Description
Clinical Pharmacology
Nonclinical Toxicology
How Supplied/Storage and Handling
Patient Counseling Information
Labels and Packages
Clinical Trials on Labetalol
ClinicalTrials.gov

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]

For patient information about Labetalol, click here

Synonyms / Brand Names:

Overview

Labetalol (Normodyne, Trandate, fixed combination with hydrochlorothiazide: Normozyde) is an alpha-1 andbeta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance.

It has a particular indication in the treatment of pregnancy-induced hypertension.

Category

Cardiovascular Drugs:Beta blockers

FDA Package Insert

| Indications and Usage | Dosage and Administration | Dosage Forms and Strengths | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages

Mechanism of Action

References

Template:WikiDoc Sources

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