LATS1

LATS, large tumor suppressor, homolog 1 (Drosophila)
Identifiers
Symbols	LATS1 ; WARTS; wts
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55843
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LATS1 219813 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

LATS, large tumor suppressor, homolog 1 (Drosophila), also known as LATS1, is a human gene.

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Further reading

• Xu T, Wang W, Zhang S; et al. (1995). "Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase". Development. 121 (4): 1053–63. PMID 7743921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tao W, Zhang S, Turenchalk GS; et al. (1999). "Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity". Nat. Genet. 21 (2): 177–81. doi:10.1038/5960. PMID 9988268.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• St John MA, Tao W, Fei X; et al. (1999). "Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction". Nat. Genet. 21 (2): 182–6. doi:10.1038/5965. PMID 9988269.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishiyama Y, Hirota T, Morisaki T; et al. (1999). "A human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis". FEBS Lett. 459 (2): 159–65. PMID 10518011.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hirota T, Morisaki T, Nishiyama Y; et al. (2000). "Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor". J. Cell Biol. 149 (5): 1073–86. PMID 10831611.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morisaki T, Hirota T, Iida S; et al. (2002). "WARTS tumor suppressor is phosphorylated by Cdc2/cyclin B at spindle poles during mitosis". FEBS Lett. 529 (2–3): 319–24. PMID 12372621.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hisaoka M, Tanaka A, Hashimoto H (2002). "Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma". Lab. Invest. 82 (10): 1427–35. PMID 12379777.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kamikubo Y, Takaori-Kondo A, Uchiyama T, Hori T (2003). "Inhibition of cell growth by conditional expression of kpm, a human homologue of Drosophila warts/lats tumor suppressor". J. Biol. Chem. 278 (20): 17609–14. doi:10.1074/jbc.M211974200. PMID 12624101.CS1 maint: Multiple names: authors list (link)
• Iida S, Hirota T, Morisaki T; et al. (2004). "Tumor suppressor WARTS ensures genomic integrity by regulating both mitotic progression and G1 tetraploidy checkpoint function". Oncogene. 23 (31): 5266–74. doi:10.1038/sj.onc.1207623. PMID 15122335.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brill LM, Salomon AR, Ficarro SB; et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang X, Yu K, Hao Y; et al. (2004). "LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1". Nat. Cell Biol. 6 (7): 609–17. doi:10.1038/ncb1140. PMID 15220930.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chan EH, Nousiainen M, Chalamalasetty RB; et al. (2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1". Oncogene. 24 (12): 2076–86. doi:10.1038/sj.onc.1208445. PMID 15688006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi Y, Miyoshi Y, Takahata C; et al. (2005). "Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers". Clin. Cancer Res. 11 (4): 1380–5. doi:10.1158/1078-0432.CCR-04-1773. PMID 15746036.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kuninaka S, Nomura M, Hirota T; et al. (2005). "The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death". Oncogene. 24 (34): 5287–98. doi:10.1038/sj.onc.1208682. PMID 16007220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bothos J, Tuttle RL, Ottey M; et al. (2005). "Human LATS1 is a mitotic exit network kinase". Cancer Res. 65 (15): 6568–75. doi:10.1158/0008-5472.CAN-05-0862. PMID 16061636.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jiang Z, Li X, Hu J; et al. (2007). "Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma". Neurosci. Res. 56 (4): 450–8. doi:10.1016/j.neures.2006.09.006. PMID 17049657.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)