Kidney stone overview

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Kidney stone from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Historical Perspective

Urinary stones was first discovered by  E. Smith, an English archaeologist, in 1901 when he found bladder stone in Egyptian mummy aged 4500-7000 year. In the 4th century B.C., when Hipprocratic Oath was made,the line that refers to stones was mentioned:  “I will not use the knife, not even on sufferers from stone, but will withdraw in favor of such men as are engaged in this work....I will not cut for the stone, but will leave this to be done by practitioners of this work.”In the 8th century B.C, treatment strategy for stone removal was developed by an Indian surgeon, Sushruta as written in Sushruta Samhita. In 1976, the first percutaneous stone surgery was performed by Fernstrom and Johansson. The famous cases of nephrolithiasis includes: in 1549, Michelangelo was diagnosed and treated for uric acid stones;in 1724, Sir Isaac Newton noted that he passed two small pea-sized stones and in 1961, Roger Moore, aka James Bond, experienced three kidney stone episodes and treated with surgery.

Classification

Nephrolithiasis may be classified according to [classification method] into 4 subtypes/groups: calcium stones, struvite stones, uric acid stones and cystine stones

Pathophysiology

Causes

Differentiating Hereditary pancreatitis from Other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Diagnosis

Diagnostic Study of choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

An x-ray may be helpful in the diagnosis of nephrolithiasis. Findings on an x-ray suggestive of nephrolithiasis include radiopaque stones such as Calcium oxalatecalcium phosphatestruvite and radiolucent stones which includes uric acid stones and cystine stones.

Ultrasound

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MRI

Other Imaging Findings

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Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

References


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