KLK15

Kallikrein-related peptidase 15
Identifiers
Symbols	KLK15 ; ACO; HSRNASPH
External IDs	Template:OMIM5 Template:MGI HomoloGene: 77571
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE KLK15 221462 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Kallikrein-related peptidase 15, also known as KLK15, is a human gene.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms.

Further reading

• Diamandis EP, Yousef GM, Luo LY; et al. (2001). "The new human kallikrein gene family: implications in carcinogenesis". Trends Endocrinol. Metab. 11 (2): 54–60. PMID 10675891.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Diamandis EP, Yousef GM (2002). "Human tissue kallikrein gene family: a rich source of novel disease biomarkers". Expert Rev. Mol. Diagn. 1 (2): 182–90. doi:10.1586/14737159.1.2.182. PMID 11901813.
• Dihanich M, Spiess M (1994). "A novel serine proteinase-like sequence from human brain". Biochim. Biophys. Acta. 1218 (2): 225–8. PMID 8018728.
• Yousef GM, Chang A, Scorilas A, Diamandis EP (2000). "Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4". Biochem. Biophys. Res. Commun. 276 (1): 125–33. doi:10.1006/bbrc.2000.3448. PMID 11006094.CS1 maint: Multiple names: authors list (link)
• Yousef GM, Scorilas A, Jung K; et al. (2001). "Molecular cloning of the human kallikrein 15 gene (KLK15). Up-regulation in prostate cancer". J. Biol. Chem. 276 (1): 53–61. doi:10.1074/jbc.M005432200. PMID 11010966.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gan L, Lee I, Smith R; et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. PMID 11054574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takayama TK, Carter CA, Deng T (2001). "Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR". Biochemistry. 40 (6): 1679–87. PMID 11327827.CS1 maint: Multiple names: authors list (link)
• Yousef GM, Scorilas A, Magklara A; et al. (2003). "The androgen-regulated gene human kallikrein 15 (KLK15) is an independent and favourable prognostic marker for breast cancer". Br. J. Cancer. 87 (11): 1294–300. doi:10.1038/sj.bjc.6600590. PMID 12439720.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yousef GM, Scorilas A, Katsaros D; et al. (2003). "Prognostic value of the human kallikrein gene 15 expression in ovarian cancer". J. Clin. Oncol. 21 (16): 3119–26. doi:10.1200/JCO.2003.09.111. PMID 12915603.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol. Chem. 387 (6): 635–824. 2006. doi:10.1515/BC.2006.081. PMID 16800723.
• Lundwall A, Band V, Blaber M; et al. (2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol. Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)