Jaundice classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Classification
Neonatal jaundice | Prehepatic jaundice | Hepatic jaundice | Posthepatic jaundice
| Jaundice classification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Conjugated and unconjugated hyperbilirubenemia | Unconjugated hyperbilirubinemia | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Obstruction of biliary tract | Intra-hepatic cholestasis | Injury to hepatocellular parenchyma | Defects of hepatocellular canalicular excretion or re-uptake in sinusoids | Increased production | Reduced uptake | Defects in conjugation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Acute | Chronic | Acquired | Inherited | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| • Primary billiary cholangitis • Primary sclerosing cholangitis • Viral hepatitis (ocassionally) • Progressive familial interahepatic cholestasis • Interahepatic cholestasis of pregnancy •Corticosteroids | • Dubin-Johnsons • Rotor syndrome | For example: • Hemolysis • Wilson disease • Extravasation • Shunt hyperbilirubinemia | • Portosystemic shunts • Drugs • Gilbert syndrome (some cases) | For example: • Neonatal • Maternal milk • Lucy-Driscoll •Hyperthyroidism • Chronic persitent hepatitis • Advanced cirrhosis | • Crigler-Najjar I • Crigler-Najjar II • Gilbert syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||