Insulinoma history and symptoms
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]
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Overview
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
History and Symptoms
Patient of insulinoma presents usually with the history of hypoglycemic episodes occurring over time with a recent increase in frequency and without any other cause known to cause hypoglycemia like exogenous insulin and hypoglycemic agents. The following are the history and symptoms of insulinoma:
History
Patients with insulinoma may have a positive history of:
- Frequent episodes of altered mental status/confusion
- Visual disturbances
- Sweating
- Negative history for exogenous insulin or oral hypoglycemic agents such as Sulfonylureas
Common Symptoms
Common symptoms of insulinoma include:[1][2]
- Altered mental status/confusion
- Visual disturbances like blurred vision/diplopia
- Sweating
- Hyperphagia
- Coma
Less Common Symptoms
Less common symptoms of insulinoma include
- Palpitations
- Seizures
- Tremors
- Behavioral disturbances
- Weakness
Neuroglycopenic symptoms | |
Visual disturbances | 59% |
Altered Mental status/Confusion | 75-80% |
Behavioral problems | 36% |
Weakness | 24-32% |
Coma | 47% |
Seizures | 36% |
Sympathetic or Adrenergic symptoms | |
Sweating | 12-69% |
Palpitations | 10-12% |
Tremors | 17-24% |
Hyperphagia/Obesity | 25-50% |
References
- ↑ Metz DC, Jensen RT (2008). "Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors". Gastroenterology. 135 (5): 1469–92. doi:10.1053/j.gastro.2008.05.047. PMC 2612755. PMID 18703061.
- ↑ Boukhman MP, Karam JH, Shaver J, Siperstein AE, Duh QY, Clark OH (1998). "Insulinoma--experience from 1950 to 1995". West J Med. 169 (2): 98–104. PMC 1305178. PMID 9735690.