Insulinoma history and symptoms
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
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Overview
Symptoms of insulinoma include diaphoresis, palpitations, confusion, seizures, and anxiety. A positive family history of multiple endocrine neoplasia type 1 or von Hippel-Lindau syndrome may be present.
History
When evaluating a patient for insulinoma, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough review of past medical history. Other specific areas of focus when obtaining the history include:
- Family history of predisposing genetic disorders such as multiple endocrine neoplasia type 1 or von Hippel-Lindau syndrome.
Symptoms
- Insulinoma is most common cause of hypoglycemia amongst other causes of endogenous hyperinsulism.
- Insulinoma secrete insulin in intermittently resulting in episodic nature of hypoglycemia.
- Common autonomic symptoms of an insulinoma include:[1]
- Common neuroglycopenenic symptoms include:[1]
- Confusion
- Behavioral change
- Personality change
- Visual disturbance
- Seizures
- Coma
- Common symptoms resulting from the catecholaminergic response to hypoglycemia:[2]
- Tremulousness
- Palpitations
- Sweating
- Hunger
- Anxiety
- Nausea
References
- ↑ 1.0 1.1 Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y; et al. (2013). "Diagnosis and management of insulinoma". World J Gastroenterol. 19 (6): 829–37. doi:10.3748/wjg.v19.i6.829. PMC 3574879. PMID 23430217.
- ↑ Insulinoma. Wikipedia. https://en.wikipedia.org/wiki/Insulinoma.