Insulinoma history and symptoms: Difference between revisions
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==History and Symptoms== | ==History and Symptoms== | ||
Patient of insulinoma presents usually with the history of [[hypoglycemic]] episodes occurring over time with a recent increase in frequency and without any other cause known to cause [[hypoglycemia]] like exogenous insulin and [[hypoglycemic agent | Patient of insulinoma presents usually with the history of [[hypoglycemic]] episodes occurring over time with a recent increase in frequency and without any other cause known to cause [[hypoglycemia]] like exogenous insulin and [[Hypoglycemic agent|hypoglycemic agent<nowiki/>s]]. The following are the history and symptoms of insulinoma: | ||
===History=== | ===History=== | ||
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Common symptoms of insulinoma include: <ref name="pmid18703061">{{cite journal| author=Metz DC, Jensen RT| title=Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors. | journal=Gastroenterology | year= 2008 | volume= 135 | issue= 5 | pages= 1469-92 | pmid=18703061 | doi=10.1053/j.gastro.2008.05.047 | pmc=2612755 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18703061 }} </ref><ref name="pmid9735690">{{cite journal| author=Boukhman MP, Karam JH, Shaver J, Siperstein AE, Duh QY, Clark OH| title=Insulinoma--experience from 1950 to 1995. | journal=West J Med | year= 1998 | volume= 169 | issue= 2 | pages= 98-104 | pmid=9735690 | doi= | pmc=1305178 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9735690 }} </ref> | Common symptoms of insulinoma include: <ref name="pmid18703061">{{cite journal| author=Metz DC, Jensen RT| title=Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors. | journal=Gastroenterology | year= 2008 | volume= 135 | issue= 5 | pages= 1469-92 | pmid=18703061 | doi=10.1053/j.gastro.2008.05.047 | pmc=2612755 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18703061 }} </ref><ref name="pmid9735690">{{cite journal| author=Boukhman MP, Karam JH, Shaver J, Siperstein AE, Duh QY, Clark OH| title=Insulinoma--experience from 1950 to 1995. | journal=West J Med | year= 1998 | volume= 169 | issue= 2 | pages= 98-104 | pmid=9735690 | doi= | pmc=1305178 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9735690 }} </ref> | ||
*[[Altered mental status]]/[[confusion]] | *[[Altered mental status]]/[[confusion]] | ||
*Visual disturbances like [[blurred vision]]/[[diplopia]] | *[[Visual disturbance|Visual disturbances]] like [[blurred vision]]/[[diplopia]] | ||
*[[Sweating]] | *[[Sweating]] | ||
*[[Hyperphagia]] | *[[Hyperphagia]] | ||
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| colspan="2" align="center" style="background: #4479BA; color: #FFFFFF; " |'''Neuroglycopenic symptoms''' | | colspan="2" align="center" style="background: #4479BA; color: #FFFFFF; " |'''Neuroglycopenic symptoms''' | ||
|- | |- | ||
|Visual | | align="center" style="background: #DCDCDC;" |[[Visual disturbance]]s | ||
|59% | | align="center" style="background: #F5F5F5;" |59% | ||
|- | |- | ||
|Altered | | align="center" style="background: #DCDCDC;" |[[Altered mental status]]/[[Confusion]] | ||
|75-80% | | align="center" style="background: #F5F5F5;" |75-80% | ||
|- | |- | ||
|Behavioral problems | | align="center" style="background: #DCDCDC;" |Behavioral problems | ||
|36% | |36% | ||
|- | |- | ||
|Weakness | | align="center" style="background: #DCDCDC;" |[[Weakness]] | ||
|24-32% | | align="center" style="background: #F5F5F5;" |24-32% | ||
|- | |- | ||
|Coma | | align="center" style="background: #DCDCDC;" |[[Coma]] | ||
|47% | | align="center" style="background: #F5F5F5;" |47% | ||
|- | |- | ||
|Seizures | | align="center" style="background: #DCDCDC;" |[[Seizures]] | ||
|36% | | align="center" style="background: #F5F5F5;" |36% | ||
|- | |- | ||
| colspan="2" align="center" style="background: #4479BA; color: #FFFFFF; " |'''Sympathetic or Adrenergic symptoms''' | | colspan="2" align="center" style="background: #4479BA; color: #FFFFFF; " |'''Sympathetic or Adrenergic symptoms''' | ||
|- | |- | ||
|Sweating | | align="center" style="background: #DCDCDC;" |[[Sweating]] | ||
|12-69% | | align="center" style="background: #F5F5F5;" |12-69% | ||
|- | |- | ||
|Palpitations | | align="center" style="background: #DCDCDC;" |[[Palpitations]] | ||
|10-12% | | align="center" style="background: #F5F5F5;" |10-12% | ||
|- | |- | ||
|Tremors | | align="center" style="background: #DCDCDC;" |[[Tremors]] | ||
|17-24% | | align="center" style="background: #F5F5F5;" |17-24% | ||
|- | |- | ||
|Hyperphagia/Obesity | | align="center" style="background: #DCDCDC;" |[[Hyperphagia]]/[[Obesity]] | ||
|25-50% | | align="center" style="background: #F5F5F5;" |25-50% | ||
|} | |} | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Medicine]] | |||
[[Category:Endocrinology]] | |||
[[Category:Up-To-Date]] |
Revision as of 16:54, 16 October 2017
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]
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Risk calculators and risk factors for Insulinoma history and symptoms |
Overview
A positive long history of frequent episodes of altered mental status/confusion, visual disturbances and sweating is suggestive of insulinoma. The most common symptoms of insulinoma include altered mental status/confusion, visual disturbances like blurred vision/diplopia, sweating, hyperphagia and coma. Less common symptoms of insulinoma include palpitations, seizures, tremors, behavioral disturbances and weakness.
History and Symptoms
Patient of insulinoma presents usually with the history of hypoglycemic episodes occurring over time with a recent increase in frequency and without any other cause known to cause hypoglycemia like exogenous insulin and hypoglycemic agents. The following are the history and symptoms of insulinoma:
History
Patients with insulinoma may have a positive history of:
- Frequent episodes of altered mental status/confusion
- Visual disturbances
- Sweating
- Negative history for exogenous insulin or oral hypoglycemic agents such as Sulfonylureas
Common Symptoms
Common symptoms of insulinoma include: [1][2]
- Altered mental status/confusion
- Visual disturbances like blurred vision/diplopia
- Sweating
- Hyperphagia
- Coma
Less Common Symptoms
Less common symptoms of insulinoma include
- Palpitations
- Seizures
- Tremors
- Behavioral disturbances
- Weakness
Neuroglycopenic symptoms | |
Visual disturbances | 59% |
Altered mental status/Confusion | 75-80% |
Behavioral problems | 36% |
Weakness | 24-32% |
Coma | 47% |
Seizures | 36% |
Sympathetic or Adrenergic symptoms | |
Sweating | 12-69% |
Palpitations | 10-12% |
Tremors | 17-24% |
Hyperphagia/Obesity | 25-50% |
References
- ↑ Metz DC, Jensen RT (2008). "Gastrointestinal neuroendocrine tumors: pancreatic endocrine tumors". Gastroenterology. 135 (5): 1469–92. doi:10.1053/j.gastro.2008.05.047. PMC 2612755. PMID 18703061.
- ↑ Boukhman MP, Karam JH, Shaver J, Siperstein AE, Duh QY, Clark OH (1998). "Insulinoma--experience from 1950 to 1995". West J Med. 169 (2): 98–104. PMC 1305178. PMID 9735690.