Infertility epidemiology and demographics: Difference between revisions

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==Epidemiology and Demographics==
==Epidemiology and Demographics==
[[Prevalence]] of infertility varies depending on the definition, i.e. on the time span involved in the failure to [[Conceive a child|conceive]]<ref name="pmid24559617">{{cite journal| author=American College of Obstetricians and Gynecologists Committee on Gynecologic Practice and Practice Committee| title=Female age-related fertility decline. Committee Opinion No. 589. | journal=Fertil Steril | year= 2014 | volume= 101 | issue= 3 | pages= 633-4 | pmid=24559617 | doi=10.1016/j.fertnstert.2013.12.032 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24559617  }}</ref>  
[[Prevalence]] of infertility varies depending on if the infertility is classified as primary or secondary infertility<ref name="pmid24559617">{{cite journal| author=American College of Obstetricians and Gynecologists Committee on Gynecologic Practice and Practice Committee| title=Female age-related fertility decline. Committee Opinion No. 589. | journal=Fertil Steril | year= 2014 | volume= 101 | issue= 3 | pages= 633-4 | pmid=24559617 | doi=10.1016/j.fertnstert.2013.12.032 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24559617  }}</ref>.


*Some estimates suggest that worldwide "between three and seven per cent of all couples or women have an unresolved problem of infertility. Many more couples, however, experience involuntary childlessness for at least one year: estimates range from 12% to 28%." <ref>{{cite journal|last=Himmel|first=W.|title=Voluntary Childlessness and being Childfree|journal=British Journal of General Practice|year=1997|issue=415 |page=  |pmc=1312893|pmid=9101672|volume=47|last2=Ittner|first2=E|last3=Kochen|first3=MM|last4=Michelmann|first4=HW|last5=Hinney|first5=B|last6=Reuter|first6=M|last7=Kallerhoff|first7=M|last8=Ringert|first8=RH|pages=111–8}}</ref>
* Some studies state that around 25% of couples globally are faced with infertility and childlessness. This number varies according to geographical region, age bracket and other such factors. <ref>{{cite journal|last=Himmel|first=W.|title=Voluntary Childlessness and being Childfree|journal=British Journal of General Practice|year=1997|issue=415 |page=  |pmc=1312893|pmid=9101672|volume=47|last2=Ittner|first2=E|last3=Kochen|first3=MM|last4=Michelmann|first4=HW|last5=Hinney|first5=B|last6=Reuter|first6=M|last7=Kallerhoff|first7=M|last8=Ringert|first8=RH|pages=111–8}}</ref>
*Fertility problems affect one in seven couples in the UK. Most couples (about 84 out of every 100) who have regular [[sexual intercourse]] (that is, every two to three days) and who do not use [[contraception]] get pregnant within a year. About 92 out of 100 couples who are trying to get pregnant do so within two years.<ref name="autogenerated1">[http://www.nice.org.uk/guidance/index.jsp?action=download&o=29271 NICE fertility guidance]</ref>
* In the US, it is estimated that around 12.5% of women between the ages of 20-44 have reported being infertile according to the National Health and Nutrition Examination survey <ref name="pmid31262522">{{cite journal| author=Kelley AS, Qin Y, Marsh EE, Dupree JM| title=Disparities in accessing infertility care in the United States: results from the National Health and Nutrition Examination Survey, 2013-16. | journal=Fertil Steril | year= 2019 | volume= 112 | issue= 3 | pages= 562-568 | pmid=31262522 | doi=10.1016/j.fertnstert.2019.04.044 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31262522  }} </ref>
*Women become less fertile as they get older. For women aged 35, about 94 out of every 100 who have regular unprotected sexual intercourse get pregnant after three years of trying. For women aged 38, however, only 77 out of every 100 do so. The effect of age upon men's fertility is less clear.<ref name="autogenerated1" />
* In general, fertility among women declines with age. Age related decline is seen in women around 32 years of age, after which there is a sharper decline in fertility and [[fecundity]]. <ref name="pmid24559617">{{cite journal| author=American College of Obstetricians and Gynecologists Committee on Gynecologic Practice and Practice Committee| title=Female age-related fertility decline. Committee Opinion No. 589. | journal=Fertil Steril | year= 2014 | volume= 101 | issue= 3 | pages= 633-4 | pmid=24559617 | doi=10.1016/j.fertnstert.2013.12.032 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24559617  }} </ref>
*In people going forward for IVF in the UK, roughly half of [[fertility]] problems with a diagnosed cause are due to problems with the man, and about half due to problems with the woman. However, about one in five cases of [[infertility]] has no clear diagnosed cause.<ref>[http://www.hfea.gov.uk/en/1215.html#Reasons_for_infertility HFEA Chart on reasons for infertility]</ref>
* [[Male factor|male infertility]] accounts for around 20-30% of the global cases of infertility. <ref name="pmid25928197">{{cite journal| author=Agarwal A, Mulgund A, Hamada A, Chyatte MR| title=A unique view on male infertility around the globe. | journal=Reprod Biol Endocrinol | year= 2015 | volume= 13 | issue= | pages= 37 | pmid=25928197 | doi=10.1186/s12958-015-0032-1 | pmc=4424520 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25928197  }} </ref>
*In Britain, male factor infertility accounts for 25% of infertile couples, while 25% remain unexplained. 50% are female causes with 25% being due to [[anovulation]] and 25% tubal problems/other.<ref>{{cite book |author=Khan, Khalid; Janesh K. Gupta; Gary Mires |title=Core clinical cases in obstetrics and gynaecology: a problem-solving approach |publisher=Hodder Arnold |location=London |year=2005 |pages=152 |isbn=0-340-81672-4 }}</ref>
*In Sweden, approximately 10% of couples wanting children are infertile.<ref>Sahlgrenska University Hospital. (translated from the Swedish sentence: [http://sahlgrenska.se/upload/SU/omrade_oss/reproduktionsmedicin/Spermadonatorinformation.pdf "Cirka 10% av alla par har problem med ofrivillig barnlöshet."])</ref> In approximately one third of these cases the man is the factor, in one third the woman is the factor, and in the remaining third the infertility is a product of factors on both parts.


==References==
==References==

Latest revision as of 07:05, 23 January 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2] Associate Editor(s)-in-Chief: Sanjana Nethagani, M.B.B.S.[3]

Overview

Infertility is more commonly seen in women >40 years of age. Women who are >35 have a decline in fertility.

Epidemiology and Demographics

Prevalence of infertility varies depending on if the infertility is classified as primary or secondary infertility[1].

  • Some studies state that around 25% of couples globally are faced with infertility and childlessness. This number varies according to geographical region, age bracket and other such factors. [2]
  • In the US, it is estimated that around 12.5% of women between the ages of 20-44 have reported being infertile according to the National Health and Nutrition Examination survey [3]
  • In general, fertility among women declines with age. Age related decline is seen in women around 32 years of age, after which there is a sharper decline in fertility and fecundity. [1]
  • male infertility accounts for around 20-30% of the global cases of infertility. [4]

References

  1. 1.0 1.1 American College of Obstetricians and Gynecologists Committee on Gynecologic Practice and Practice Committee (2014). "Female age-related fertility decline. Committee Opinion No. 589". Fertil Steril. 101 (3): 633–4. doi:10.1016/j.fertnstert.2013.12.032. PMID 24559617.
  2. Himmel, W.; Ittner, E; Kochen, MM; Michelmann, HW; Hinney, B; Reuter, M; Kallerhoff, M; Ringert, RH (1997). "Voluntary Childlessness and being Childfree". British Journal of General Practice. 47 (415): 111–8. PMC 1312893. PMID 9101672.
  3. Kelley AS, Qin Y, Marsh EE, Dupree JM (2019). "Disparities in accessing infertility care in the United States: results from the National Health and Nutrition Examination Survey, 2013-16". Fertil Steril. 112 (3): 562–568. doi:10.1016/j.fertnstert.2019.04.044. PMID 31262522.
  4. Agarwal A, Mulgund A, Hamada A, Chyatte MR (2015). "A unique view on male infertility around the globe". Reprod Biol Endocrinol. 13: 37. doi:10.1186/s12958-015-0032-1. PMC 4424520. PMID 25928197.