Infertility risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2] Associate Editor(s)-in-Chief: Sanjana Nethagani, M.B.B.S.[3]


Advanced age is the most important modifiable risk factor for women with infertility. Other risk factors include diabetes mellitus, hypothyroidism, PCOS etc.

Infertility Risk factors

Several factors play a role in infertility among women, such as:[1]


  1. Practice Committee of the American Society for Reproductive Medicine. Electronic address: Practice Committee of the American Society for Reproductive Medicine (2018). "Smoking and infertility: a committee opinion". Fertil Steril. 110 (4): 611–618. doi:10.1016/j.fertnstert.2018.06.016. PMID 30196946.
  2. Steiner AZ, Pritchard D, Stanczyk FZ, Kesner JS, Meadows JW, Herring AH; et al. (2017). "Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age". JAMA. 318 (14): 1367–1376. doi:10.1001/jama.2017.14588. PMC 5744252. PMID 29049585.
  3. Thong EP, Codner E, Laven JSE, Teede H (2020). "Diabetes: a metabolic and reproductive disorder in women". Lancet Diabetes Endocrinol. 8 (2): 134–149. doi:10.1016/S2213-8587(19)30345-6. PMID 31635966.
  4. Broughton DE, Moley KH (2017). "Obesity and female infertility: potential mediators of obesity's impact". Fertil Steril. 107 (4): 840–847. doi:10.1016/j.fertnstert.2017.01.017. PMID 28292619.
  5. Hjollund NH, Jensen TK, Bonde JP, Henriksen TB, Andersson AM, Kolstad HA; et al. (1999). "Distress and reduced fertility: a follow-up study of first-pregnancy planners". Fertil Steril. 72 (1): 47–53. doi:10.1016/s0015-0282(99)00186-7. PMID 10428147.