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Interleukin 1 family, member 7 (zeta)
Symbols IL1F7 ; FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H4; IL-1RP1; IL1H4; IL1RP1
External IDs Template:OMIM5
RNA expression pattern
More reference expression data
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Interleukin 1 family, member 7 (zeta), also known as IL1F7, is a human gene.[1]

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.[1]


  1. 1.0 1.1 "Entrez Gene: IL1F7 interleukin 1 family, member 7 (zeta)".

Further reading

  • Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes". Genomics. 19 (2): 382–4. doi:10.1006/geno.1994.1076. PMID 8188271.
  • Nothwang HG, Strahm B, Denich D; et al. (1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13". Genomics. 41 (3): 370–8. doi:10.1006/geno.1997.4654. PMID 9169134.
  • Mulero JJ, Pace AM, Nelken ST; et al. (1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene". Biochem. Biophys. Res. Commun. 263 (3): 702–6. doi:10.1006/bbrc.1999.1440. PMID 10512743.
  • Smith DE, Renshaw BR, Ketchem RR; et al. (2000). "Four new members expand the interleukin-1 superfamily". J. Biol. Chem. 275 (2): 1169–75. PMID 10625660.
  • Kumar S, McDonnell PC, Lehr R; et al. (2000). "Identification and initial characterization of four novel members of the interleukin-1 family". J. Biol. Chem. 275 (14): 10308–14. PMID 10744718.
  • Busfield SJ, Comrack CA, Yu G; et al. (2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2". Genomics. 66 (2): 213–6. doi:10.1006/geno.2000.6184. PMID 10860666.
  • Barton JL, Herbst R, Bosisio D; et al. (2001). "A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities". Eur. J. Immunol. 30 (11): 3299–308. PMID 11093146.
  • Pan G, Risser P, Mao W; et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp". Cytokine. 13 (1): 1–7. doi:10.1006/cyto.2000.0799. PMID 11145836.
  • Lin H, Ho AS, Haley-Vicente D; et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member". J. Biol. Chem. 276 (23): 20597–602. doi:10.1074/jbc.M010095200. PMID 11278614.
  • Debets R, Timans JC, Homey B; et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2". J. Immunol. 167 (3): 1440–6. PMID 11466363.
  • Sims JE, Nicklin MJ, Bazan JF; et al. (2001). "A new nomenclature for IL-1-family genes". Trends Immunol. 22 (10): 536–7. PMID 11574262.
  • Nicklin MJ, Barton JL, Nguyen M; et al. (2002). "A sequence-based map of the nine genes of the human interleukin-1 cluster". Genomics. 79 (5): 718–25. doi:10.1006/geno.2002.6751. PMID 11991722.
  • Taylor SL, Renshaw BR, Garka KE; et al. (2002). "Genomic organization of the interleukin-1 locus". Genomics. 79 (5): 726–33. doi:10.1006/geno.2002.6752. PMID 11991723.
  • Kumar S, Hanning CR, Brigham-Burke MR; et al. (2003). "Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production". Cytokine. 18 (2): 61–71. PMID 12096920.
  • Bufler P, Azam T, Gamboni-Robertson F; et al. (2002). "A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13723–8. doi:10.1073/pnas.212519099. PMID 12381835.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Gao W, Kumar S, Lotze MT; et al. (2003). "Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity". J. Immunol. 170 (1): 107–13. PMID 12496389.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Grimsby S, Jaensson H, Dubrovska A; et al. (2005). "Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity". FEBS Lett. 577 (1–2): 93–100. doi:10.1016/j.febslet.2004.09.069. PMID 15527767.
  • Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.

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