IFI30: Difference between revisions
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'''Gamma-interferon-inducible lysosomal thiol reductase''' is an [[enzyme]] that in humans is encoded by the ''IFI30'' [[gene]].<ref name="pmid3136170">{{cite journal |vauthors=Luster AD, Weinshank RL, Feinman R, Ravetch JV | title = Molecular and biochemical characterization of a novel gamma-interferon-inducible protein | journal = J Biol Chem | volume = 263 | issue = 24 | pages = 12036–43 |date=Sep 1988 | pmid = 3136170 | pmc = | doi = }}</ref><ref name="pmid10639150">{{cite journal |vauthors=Arunachalam B, Phan UT, Geuze HJ, Cresswell P | title = Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT) | journal = Proc Natl Acad Sci U S A | volume = 97 | issue = 2 | pages = 745–50 |date=Mar 2000 | pmid = 10639150 | pmc = 15401 | doi =10.1073/pnas.97.2.745 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IFI30 interferon, gamma-inducible protein 30| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10437| accessdate = }}</ref> | '''Gamma-interferon-inducible lysosomal thiol reductase''' is an [[enzyme]] that in humans is encoded by the ''IFI30'' [[gene]].<ref name="pmid3136170">{{cite journal |vauthors=Luster AD, Weinshank RL, Feinman R, Ravetch JV | title = Molecular and biochemical characterization of a novel gamma-interferon-inducible protein | journal = J Biol Chem | volume = 263 | issue = 24 | pages = 12036–43 |date=Sep 1988 | pmid = 3136170 | pmc = | doi = }}</ref><ref name="pmid10639150">{{cite journal |vauthors=Arunachalam B, Phan UT, Geuze HJ, Cresswell P | title = Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT) | journal = Proc Natl Acad Sci U S A | volume = 97 | issue = 2 | pages = 745–50 |date=Mar 2000 | pmid = 10639150 | pmc = 15401 | doi =10.1073/pnas.97.2.745 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IFI30 interferon, gamma-inducible protein 30| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10437| accessdate = }}</ref> | ||
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| summary_text = The | | summary_text = The [[wikt:protei|protei]]n encoded by this gene is a [[lysosomal]] thiol [[reductase]] that at low [[pH]] can reduce protein [[disulfide bonds]]. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other [[cell types]]. This enzyme has an important role in MHC class II-restricted [[antigen processing]].<ref name="entrez" /> | ||
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Latest revision as of 22:17, 18 February 2018
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Gamma-interferon-inducible lysosomal thiol reductase is an enzyme that in humans is encoded by the IFI30 gene.[1][2][3]
The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.[3]
References
- ↑ Luster AD, Weinshank RL, Feinman R, Ravetch JV (Sep 1988). "Molecular and biochemical characterization of a novel gamma-interferon-inducible protein". J Biol Chem. 263 (24): 12036–43. PMID 3136170.
- ↑ Arunachalam B, Phan UT, Geuze HJ, Cresswell P (Mar 2000). "Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT)". Proc Natl Acad Sci U S A. 97 (2): 745–50. doi:10.1073/pnas.97.2.745. PMC 15401. PMID 10639150.
- ↑ 3.0 3.1 "Entrez Gene: IFI30 interferon, gamma-inducible protein 30".
Further reading
- Csányi E (1977). "[Endre Kótai; 1914-1976]". Magyar traumatológia, orthopaedia és helyreállító sebészet. 20 (1): 1. PMID 16170.
- Sabin NM (1977). "Letters to the editors". The Journal of the Wisconsin Dental Association. 52 (1): 9. PMID 1069150.
- Phan UT, Arunachalam B, Cresswell P (2000). "Gamma-interferon-inducible lysosomal thiol reductase (GILT). Maturation, activity, and mechanism of action". J. Biol. Chem. 275 (34): 25907–14. doi:10.1074/jbc.M003459200. PMID 10852914.
- Phan UT, Maric M, Dick TP, Cresswell P (2001). "Multiple species express thiol oxidoreductases related to GILT". Immunogenetics. 53 (4): 342–6. doi:10.1007/s002510100323. PMID 11491538.
- Haque MA, Li P, Jackson SK, et al. (2002). "Absence of γ-Interferon–inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes". J. Exp. Med. 195 (10): 1267–77. doi:10.1084/jem.20011853. PMC 2193747. PMID 12021307.
- Phan UT, Lackman RL, Cresswell P (2002). "Role of the C-terminal propeptide in the activity and maturation of γ-interferon-inducible lysosomal thiol reductase (GILT)". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12298–303. doi:10.1073/pnas.182430499. PMC 129439. PMID 12198183.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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