IFI30

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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RefSeq (mRNA)

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RefSeq (protein)

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Gamma-interferon-inducible lysosomal thiol reductase is an enzyme that in humans is encoded by the IFI30 gene.[1][2][3]

The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.[3]

References

  1. Luster AD, Weinshank RL, Feinman R, Ravetch JV (Sep 1988). "Molecular and biochemical characterization of a novel gamma-interferon-inducible protein". J Biol Chem. 263 (24): 12036–43. PMID 3136170.
  2. Arunachalam B, Phan UT, Geuze HJ, Cresswell P (Mar 2000). "Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a Gamma-interferon-inducible lysosomal thiol reductase (GILT)". Proc Natl Acad Sci U S A. 97 (2): 745–50. doi:10.1073/pnas.97.2.745. PMC 15401. PMID 10639150.
  3. 3.0 3.1 "Entrez Gene: IFI30 interferon, gamma-inducible protein 30".

Further reading