Hereditary nonpolyposis colorectal cancer: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
(20 intermediate revisions by 6 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
'''For patient information, click [[Hereditary nonpolyposis colorectal cancer (patient information)|here]]'''
'''For patient information, click [[Hereditary nonpolyposis colorectal cancer (patient information)|here]]'''
{{Infobox_Disease |
  Name          = {{PAGENAME}} |
  Image          = |
  Caption        = |
  DiseasesDB    = 5812 |
  ICD10          = {{ICD10|C|18||c|15}}-{{ICD10|C|20||c|15}} |
  ICD9          = {{ICD9|153.0}}-{{ICD9|154.1}} |
  ICDO          = |
  OMIM          = 120435 |
  OMIM_mult      = {{OMIM2|609310}} {{OMIM2|114400}} |
  MedlinePlus    = |
  MeshID        = D003123 |
}}
{{Hereditary nonpolyposis colorectal cancer}}
{{Hereditary nonpolyposis colorectal cancer}}
{{CMG}}
{{CMG}}{{AE}}{{MV}}{{Akram}}


'''''Synonyms and Keywords:''''' Lynch syndrome; HNPCC
'''''Synonyms and Keywords:''''' Lynch syndrome; HNPCC; Hereditary non-polyposis colorectal carcinoma; Lynch II syndrome; Lynch I syndrome; Familial nonpolyposis colon cancer; Hereditary nonpolyposis colorectal neoplasms


==[[Hereditary nonpolyposis colorectal cancer overview|Overview]]==
==[[Hereditary nonpolyposis colorectal cancer overview|Overview]]==


==[[Hereditary nonpolyposis colorectal cancer historical perspective|Historical Perspective]]==
==[[Hereditary nonpolyposis colorectal cancer historical perspective|Historical Perspective]]==
*In 1971, Lynch and Krush updated the studies of the family, in which the disease eventually became known as hereditary nonpolyposis colon cancer (HNPCC), also known as Lynch Syndrome<ref name="pmid25276405">{{cite journal| author=Schlussel AT, Gagliano RA, Seto-Donlon S, Eggerding F, Donlon T, Berenberg J et al.| title=The evolution of colorectal cancer genetics-Part 1: from discovery to practice. | journal=J Gastrointest Oncol | year= 2014 | volume= 5 | issue= 5 | pages= 326-35 | pmid=25276405 | doi=10.3978/j.issn.2078-6891.2014.069 | pmc=PMC4173047 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25276405  }} </ref>


==[[Hereditary nonpolyposis colorectal cancer classification|Classification]]==
==[[Hereditary nonpolyposis colorectal cancer classification|Classification]]==
Line 31: Line 15:


==[[Hereditary nonpolyposis colorectal cancer causes|Causes]]==
==[[Hereditary nonpolyposis colorectal cancer causes|Causes]]==
==[[Hereditary nonpolyposis colorectal cancer differential diagnosis|Differentiating Hereditary Nonpolyposis Colorectal Cancer from Other Diseases]]==


==[[Hereditary nonpolyposis colorectal cancer epidemiology and demographics|Epidemiology and Demographics]]==
==[[Hereditary nonpolyposis colorectal cancer epidemiology and demographics|Epidemiology and Demographics]]==
Line 37: Line 23:


==[[Hereditary nonpolyposis colorectal cancer screening|Screening]]==
==[[Hereditary nonpolyposis colorectal cancer screening|Screening]]==
==[[Hereditary nonpolyposis colorectal cancer differential diagnosis|Differentiating Hereditary nonpolyposis colorectal cancer from other Diseases]]==


==[[Hereditary nonpolyposis colorectal cancer natural history|Natural History, Complications and Prognosis]]==
==[[Hereditary nonpolyposis colorectal cancer natural history|Natural History, Complications and Prognosis]]==


==Diagnosis==
==Diagnosis==
[[Hereditary nonpolyposis colorectal cancer staging|Staging]] | [[Hereditary nonpolyposis colorectal cancer history and symptoms|History and Symptoms]] | [[Hereditary nonpolyposis colorectal cancer physical examination|Physical Examination]] | [[Hereditary nonpolyposis colorectal cancer laboratory tests|Laboratory Findings ]] | [[Hereditary nonpolyposis colorectal cancer chest x ray|Chest X Ray]] | [[Hereditary nonpolyposis colorectal cancer CT|CT]] | [[Hereditary nonpolyposis colorectal cancer MRI|MRI]] | [[Hereditary nonpolyposis colorectal cancer ultrasound|Ultrasound]] | [[Hereditary nonpolyposis colorectal cancer other imaging findings|Other Imaging Findings]] | [[Hereditary nonpolyposis colorectal cancer other diagnostic studies#Genetic testing|Genetic testing]]
[[Hereditary nonpolyposis colorectal cancer staging|Staging]] | [[Hereditary nonpolyposis colorectal cancer history and symptoms|History and Symptoms]] | [[Hereditary nonpolyposis colorectal cancer physical examination|Physical Examination]] | [[Hereditary nonpolyposis colorectal cancer laboratory tests|Laboratory Findings ]] | [[Hereditary nonpolyposis colorectal cancer chest x ray|Chest X Ray]] | [[Hereditary nonpolyposis colorectal cancer CT|CT]] | [[Hereditary nonpolyposis colorectal cancer MRI|MRI]] | [[Hereditary nonpolyposis colorectal cancer ultrasound|Ultrasound]] | [[Hereditary nonpolyposis colorectal cancer other imaging findings|Other Imaging Findings]] | [[Hereditary nonpolyposis colorectal cancer other diagnostic studies|Other diagnostic studies]]


==Treatment==
==Treatment==
[[Hereditary nonpolyposis colorectal cancer medical therapy|Medical Therapy]] | [[Hereditary nonpolyposis colorectal cancer surgery|Surgery]] | [[Hereditary nonpolyposis colorectal cancer primary prevention|Primary Prevention]] | [[Hereditary nonpolyposis colorectal cancer secondary prevention|Secondary Prevention]] | [[Hereditary nonpolyposis colorectal cancer cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Hereditary nonpolyposis colorectal cancer future or investigational therapies|Future or Investigational Therapies]]
[[Hereditary nonpolyposis colorectal cancer medical therapy|Medical Therapy]] | [[Hereditary nonpolyposis colorectal cancer surgery|Surgery]] | [[Hereditary nonpolyposis colorectal cancer primary prevention|Primary Prevention]] | [[Hereditary nonpolyposis colorectal cancer secondary prevention|Secondary Prevention]] | [[Hereditary nonpolyposis colorectal cancer cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Hereditary nonpolyposis colorectal cancer future or investigational therapies|Future or Investigational Therapies]]


==External Links==
* [http://siadat.info/hnpcc.htm Sample histology slides of HNPCC at siadat.info]
* [http://siadat.info/hnpcc.htm#hnpcc03 Aberrant Cytokeratin 20 expression in HNPCC at siadat.info]
* [http://siadat.info/hnpcc.htm#hnpcc04 Aberrant Cytokeratin 7 expression in HNPCC at siadat.info]
* [http://ghr.nlm.nih.gov/condition=hereditarynonpolyposiscolorectalcancer FAQs on HNPCC] from the [[National Institute of Health]]
* {{GeneTests|hnpcc}}
* [http://www.annalsnyas.org/cgi/content/abstract/910/1/62 Pathology of Hereditary Nonpolyposis Colorectal Cancer at annalsnyas.org]
[[de:Hereditäres non-polypöses kolorektales Karzinom]]
[[pl:Zespół Lyncha]]


[[Category:Disease]]
[[Category:Disease]]
Line 73: Line 45:
{{WikiDoc Help Menu}}
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
{{WikiDoc Sources}}
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Gastroenterology]]
[[Category:Surgery]]

Latest revision as of 22:33, 28 January 2019

For patient information, click here

Hereditary Nonpolyposis Colorectal Cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Hereditary Nonpolyposis Colorectal Cancer from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Hereditary nonpolyposis colorectal cancer On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Hereditary nonpolyposis colorectal cancer

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Hereditary nonpolyposis colorectal cancer

CDC on Hereditary nonpolyposis colorectal cancer

Hereditary nonpolyposis colorectal cancer in the news

Blogs on Hereditary nonpolyposis colorectal cancer

Directions to Hospitals Treating Hereditary nonpolyposis colorectal cancer

Risk calculators and risk factors for Hereditary nonpolyposis colorectal cancer

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]Ali Akram, M.B.B.S.[3]

Synonyms and Keywords: Lynch syndrome; HNPCC; Hereditary non-polyposis colorectal carcinoma; Lynch II syndrome; Lynch I syndrome; Familial nonpolyposis colon cancer; Hereditary nonpolyposis colorectal neoplasms

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Hereditary Nonpolyposis Colorectal Cancer from Other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging | History and Symptoms | Physical Examination | Laboratory Findings | Chest X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other diagnostic studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies


Template:WikiDoc Sources