HMGB2: Difference between revisions

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* {{cite journal | vauthors = Dubois T, Howell S, Zemlickova E, Aitken A | title = Identification of casein kinase Ialpha interacting protein partners | journal = FEBS Letters | volume = 517 | issue = 1-3 | pages = 167–71 | date = Apr 2002 | pmid = 12062430 | doi = 10.1016/S0014-5793(02)02614-5 }}
* {{cite journal | vauthors = Dubois T, Howell S, Zemlickova E, Aitken A | title = Identification of casein kinase Ialpha interacting protein partners | journal = FEBS Letters | volume = 517 | issue = 1-3 | pages = 167–71 | date = Apr 2002 | pmid = 12062430 | doi = 10.1016/S0014-5793(02)02614-5 }}
* {{cite journal | vauthors = Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J | title = Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A | journal = Nature Immunology | volume = 4 | issue = 2 | pages = 145–53 | date = Feb 2003 | pmid = 12524539 | doi = 10.1038/ni885 }}
* {{cite journal | vauthors = Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J | title = Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A | journal = Nature Immunology | volume = 4 | issue = 2 | pages = 145–53 | date = Feb 2003 | pmid = 12524539 | doi = 10.1038/ni885 }}
* {{cite journal | vauthors = Lv X, Xu DD, Liu DP, Li L, Hao DL, Liang CC | title = High-mobility group protein 2 may be involved in the locus control region regulation of the beta-globin gene cluster | journal = Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire | volume = 80 | issue = 6 | pages = 765–70 | year = 2003 | pmid = 12555809 | doi = 10.1139/o02-164 }}
* {{cite journal | vauthors = Lv X, Xu DD, Liu DP, Li L, Hao DL, Liang CC | title = High-mobility group protein 2 may be involved in the locus control region regulation of the beta-globin gene cluster | journal = Biochemistry and Cell Biology | volume = 80 | issue = 6 | pages = 765–70 | year = 2003 | pmid = 12555809 | doi = 10.1139/o02-164 }}
* {{cite journal | vauthors = Pallier C, Scaffidi P, Chopineau-Proust S, Agresti A, Nordmann P, Bianchi ME, Marechal V | title = Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes | journal = Molecular Biology of the Cell | volume = 14 | issue = 8 | pages = 3414–26 | date = Aug 2003 | pmid = 12925773 | pmc = 181577 | doi = 10.1091/mbc.E02-09-0581 }}
* {{cite journal | vauthors = Pallier C, Scaffidi P, Chopineau-Proust S, Agresti A, Nordmann P, Bianchi ME, Marechal V | title = Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes | journal = Molecular Biology of the Cell | volume = 14 | issue = 8 | pages = 3414–26 | date = Aug 2003 | pmid = 12925773 | pmc = 181577 | doi = 10.1091/mbc.E02-09-0581 }}
* {{cite journal | vauthors = Aird KM, Iwasaki O,  Kossenkov AV,  Tanizawa H,  Fatkhutdinov N, Bitler BG,  Le L,  Alicea G, Yang TL,  Johnson FB, Noma K, Zhang R | title = HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci | journal = JCB | volume =  | issue =  | pages =  | date = Oct 2016 | pmid =  | doi = 10.1083/jcb.201608026 }} <small>Loss of HMGB2 (High-mobility group protein box 2) during [[senescence]] blunts SASP (senescence-associated secretory phenotype) [[gene]] expression by allowing for spreading of repressive [[heterochromatin]] into SASP gene loci. This correlates with incorporation of SASP gene loci into SAHF (senescence-associated heterochromatin foci), which in turn represses SASP gene expression</small>  
* {{cite journal | vauthors = Aird KM, Iwasaki O,  Kossenkov AV,  Tanizawa H,  Fatkhutdinov N, Bitler BG,  Le L,  Alicea G, Yang TL,  Johnson FB, Noma K, Zhang R | title = HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci | journal = JCB | volume =  | issue =  | pages =  | date = Oct 2016 | pmid =  | doi = 10.1083/jcb.201608026 | url =http://jcb.rupress.org/content/jcb/215/3/325.full.pdf}} <small>Loss of HMGB2 (High-mobility group protein box 2) during [[senescence]] blunts SASP (senescence-associated secretory phenotype) [[gene]] expression by allowing for spreading of repressive [[heterochromatin]] into SASP gene loci. This correlates with incorporation of SASP gene loci into SAHF (senescence-associated heterochromatin foci), which in turn represses SASP gene expression</small>  
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Revision as of 15:06, 4 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene.[1][2]

Function

This gene encodes a member of the non-histone chromosomal high-mobility group protein family.[3] The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.[2]

References

  1. Majumdar A, Brown D, Kerby S, Rudzinski I, Polte T, Randhawa Z, Seidman MM (Dec 1991). "Sequence of human HMG2 cDNA". Nucleic Acids Research. 19 (23): 6643. doi:10.1093/nar/19.23.6643. PMC 329240. PMID 1754403.
  2. 2.0 2.1 "Entrez Gene: HMGB2 high-mobility group box 2".
  3. Murugesapillai D, McCauley MJ, Maher LJ, Williams MC (15 November 2016). "Single-molecule studies of high-mobility group B architectural DNA bending proteins". Biophysical Reviews. doi:10.1007/s12551-016-0236-4.

Further reading

External links