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{{Guillain-Barré syndrome}}
{{Guillain-Barré syndrome}}


{{CMG}}; '''Associate Editors-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, MBBS]] [mailto:psingh@perfuse.org]
{{CMG}}; {{AE}} {{Fs}}


==Overview==
==Overview==
'''Guillain-Barré syndrome''' ('''GBS''') is an acute, [[autoimmune]], [[neuropathy|polyradiculoneuropathy]] affecting the [[peripheral nervous system]], usually triggered by an acute infectious process. Anyone can develop GBS; however, it is more common among older adults. The incidence of GBS increases with age, and people older than 50 years are at greatest risk for developing GBS. Since 1976, many studies have been done to see if other [[flu vaccines]] may cause GBS. In most studies no link was found between the flu vaccine and GBS. For the most part, the chance of getting very ill from flu is far higher than the chance of getting GBS after getting the '''flu vaccine'''.
[[Risk factor|Risk factors]] in the development of Guillain Barre syndrome include: [[Rabies vaccine]] and swine-flu influenza vaccine.


==Risk factors==
==Risk Factors==
* Anyone can develop [[Guillain-Barré syndrome]]; however, it is more common among older adults. The incidence of GBS increases with age, and people older than 50 years are at greatest risk for developing GBS.
* [[Risk factor|Risk factors]] in the development of Guillain Barre syndrome include:
* In 1976 there was a small increased risk of GBS following vaccination with an influenza vaccine made to protect against a swine flu virus.
** There are some evidence demonstrating that there might be a connection between [[vaccination]] and Guillain Barre syndrome.
* Since 1976, many studies have been done to see if other flu vaccines may cause GBS. In most studies no link was found between the flu vaccine and GBS.
*** These vaccines include:<ref name="pmid2450302">{{cite journal |vauthors=Hemachudha T, Griffin DE, Chen WW, Johnson RT |title=Immunologic studies of rabies vaccination-induced Guillain-Barré syndrome |journal=Neurology |volume=38 |issue=3 |pages=375–8 |date=March 1988 |pmid=2450302 |doi= |url=}}</ref><ref name="pmid1851395">{{cite journal |vauthors=Safranek TJ, Lawrence DN, Kurland LT, Culver DH, Wiederholt WC, Hayner NS, Osterholm MT, O'Brien P, Hughes JM |title=Reassessment of the association between Guillain-Barré syndrome and receipt of swine influenza vaccine in 1976-1977: results of a two-state study. Expert Neurology Group |journal=Am. J. Epidemiol. |volume=133 |issue=9 |pages=940–51 |date=May 1991 |pmid=1851395 |doi= |url=}}</ref>
* However, two studies did suggest that about 1 more person out of 1 million people vaccinated with seasonal flu vaccine may develop GBS. This continues to be studied.
**** [[Rabies vaccine]]
* The increased risk was approximately 1 additional case of GBS per 100,000 people who got the swine flu vaccine.
**** Swine-flu influenza vaccine
* The Institute of Medicine (IOM) conducted a thorough scientific review of this issue in 2003 and concluded that people who received the 1976 swine influenza vaccine had an increased risk for developing GBS.
* Scientists have multiple theories on why this increased risk may have occurred, but the exact reason for this association remains unknown.
*It is important to keep in mind that severe illness and death are associated with influenza, and vaccination is the best way to prevent influenza infection and its complications. For the most part, the chance of getting very ill from flu is far higher than the chance of getting GBS after getting the flu vaccine


==External link==
[http://www.cdc.gov/flu/protect/vaccine/guillainbarre.htm link name]
==References==
==References==
{{reflist|2}}
{{reflist|2}}
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[[Category:Autoimmune diseases]]
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[[Category:Syndromes]]
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Latest revision as of 16:43, 27 December 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.

Overview

Risk factors in the development of Guillain Barre syndrome include: Rabies vaccine and swine-flu influenza vaccine.

Risk Factors

  • Risk factors in the development of Guillain Barre syndrome include:
    • There are some evidence demonstrating that there might be a connection between vaccination and Guillain Barre syndrome.

References

  1. Hemachudha T, Griffin DE, Chen WW, Johnson RT (March 1988). "Immunologic studies of rabies vaccination-induced Guillain-Barré syndrome". Neurology. 38 (3): 375–8. PMID 2450302.
  2. Safranek TJ, Lawrence DN, Kurland LT, Culver DH, Wiederholt WC, Hayner NS, Osterholm MT, O'Brien P, Hughes JM (May 1991). "Reassessment of the association between Guillain-Barré syndrome and receipt of swine influenza vaccine in 1976-1977: results of a two-state study. Expert Neurology Group". Am. J. Epidemiol. 133 (9): 940–51. PMID 1851395.

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