Guillain-Barré syndrome natural history, complications, and prognosis: Difference between revisions
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{{Guillain-Barré syndrome}} | {{Guillain-Barré syndrome}} | ||
{{CMG}}; '''Associate Editors-In-Chief:''' | {{CMG}}; '''Associate Editors-In-Chief:''' {{Fs}} | ||
==Overview== | ==Overview== | ||
The [[Symptom|symptoms]] of Guillain Barre syndrome typically develop 1 to 3 weeks after the Antecedent Infection. If left untreated, 65% of patients with Guillain Barre syndrome will recover with no permanent [[disability]]. 35% of them will not fully recover. 8% of these 35% will die from [[Complications|complication]] and others will have permanent [[Disability|disabilities]]. | |||
Common complications of GBS include: [[respiratory failure]], [[Autonomic dysfunction|autonomic failure]], bulbar pulsy, [[Deep vein thrombosis]], [[Cardiac arrhythmia]], [[Pain]], [[Urinary retention]], [[Ileus]] and persistent [[fatigue]] | |||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
=== Natural history === | === Natural history === | ||
* | * The [[Symptom|symptoms]] of Guillain Barre syndrome typically develop 1 to 3 weeks after the Antecedent Infection. | ||
* | * If left untreated, 65% of patients with Guillain Barre syndrome will recover with no permanent [[disability]]. | ||
* | * 35% of them will not fully recover. 8% of these 35% will die from [[Complications|complication]] and others will have permanent [[Disability|disabilities]]. | ||
* | * Treatment will just reduce the recovery period and has no effect on natural history of the disease. | ||
* | * The first [[Symptom|symptoms]] are lower extremities [[weakness]] and [[paresthesia]].<ref name="pmid9818934">{{cite journal |vauthors=Hadden RD, Cornblath DR, Hughes RA, Zielasek J, Hartung HP, Toyka KV, Swan AV |title=Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group |journal=Ann. Neurol. |volume=44 |issue=5 |pages=780–8 |date=November 1998 |pmid=9818934 |doi=10.1002/ana.410440512 |url=}}</ref><ref name="pmid1565119">{{cite journal |vauthors=Bradshaw DY, Jones HR |title=Guillain-Barré syndrome in children: clinical course, electrodiagnosis, and prognosis |journal=Muscle Nerve |volume=15 |issue=4 |pages=500–6 |date=April 1992 |pmid=1565119 |doi=10.1002/mus.880150415 |url=}}</ref><ref name=":0">{{cite book | last = Mattle | first = Heinrich | title = Fundamentals of neurology : an illustrated guide | publisher = Thieme | location = Stuttgart New York | year = 2017 | isbn = 9783131364524 }}</ref> | ||
===Complications=== | ===Complications=== | ||
* Common complications of GBS include:<ref name="pmid15668421">{{cite journal |vauthors=Dornonville de la Cour C, Jakobsen J |title=Residual neuropathy in long-term population-based follow-up of Guillain-Barré syndrome |journal=Neurology |volume=64 |issue=2 |pages=246–53 |date=January 2005 |pmid=15668421 |doi=10.1212/01.WNL.0000149521.65474.83 |url=}}</ref><ref name="pmid9344309">{{cite journal |vauthors=Meythaler JM |title=Rehabilitation of Guillain-Barré syndrome |journal=Arch Phys Med Rehabil |volume=78 |issue=8 |pages=872–9 |date=August 1997 |pmid=9344309 |doi= |url=}}</ref> | * Common complications of GBS include:<ref name="pmid15668421">{{cite journal |vauthors=Dornonville de la Cour C, Jakobsen J |title=Residual neuropathy in long-term population-based follow-up of Guillain-Barré syndrome |journal=Neurology |volume=64 |issue=2 |pages=246–53 |date=January 2005 |pmid=15668421 |doi=10.1212/01.WNL.0000149521.65474.83 |url=}}</ref><ref name="pmid9344309">{{cite journal |vauthors=Meythaler JM |title=Rehabilitation of Guillain-Barré syndrome |journal=Arch Phys Med Rehabil |volume=78 |issue=8 |pages=872–9 |date=August 1997 |pmid=9344309 |doi= |url=}}</ref> | ||
** [[respiratory failure]] | ** [[respiratory failure]] | ||
** Autonomic failure | ** [[Autonomic dysfunction|Autonomic failure]] | ||
** Bulbar pulsy | ** Bulbar pulsy | ||
** [[Deep vein thrombosis]] | ** [[Deep vein thrombosis]] | ||
** Cardiac arrhythmia | ** [[Cardiac arrhythmia]] | ||
** Pain | ** [[Pain]] | ||
** Urinary retention | ** [[Urinary retention]] | ||
** Ileus | ** [[Ileus]] | ||
** Persistent fatigue | ** Persistent [[fatigue]] | ||
===Prognosis=== | ===Prognosis=== | ||
* About 65% of patients with GBS will fully recover with no permanent disability. | * About 65% of patients with GBS will fully recover with no permanent [[disability]]. | ||
* 35% of them do not fully recover. 8% of this group will die from GBS complication and others will have permanent disabilities. | * 35% of them do not fully recover. 8% of this group will die from GBS [[complication]] and others will have permanent [[Disability|disabilities]]. | ||
* Treatment of GBS just reduce the recovery time and doesn’t affect prognosis. | * Treatment of GBS just reduce the recovery time and doesn’t affect [[prognosis]].<ref name="pmid9436731">{{cite journal |vauthors=Rees JH, Thompson RD, Smeeton NC, Hughes RA |title=Epidemiological study of Guillain-Barré syndrome in south east England |journal=J. Neurol. Neurosurg. Psychiatry |volume=64 |issue=1 |pages=74–7 |date=January 1998 |pmid=9436731 |pmc=2169900 |doi= |url=}}</ref> | ||
* Overally, older patients will have worst prognosis in comparison to children who discover very fast. | * Overally, older patients will have worst prognosis in comparison to children who discover very fast.<ref name="pmid9818934">{{cite journal |vauthors=Hadden RD, Cornblath DR, Hughes RA, Zielasek J, Hartung HP, Toyka KV, Swan AV |title=Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group |journal=Ann. Neurol. |volume=44 |issue=5 |pages=780–8 |date=November 1998 |pmid=9818934 |doi=10.1002/ana.410440512 |url=}}</ref><ref name="pmid1565119">{{cite journal |vauthors=Bradshaw DY, Jones HR |title=Guillain-Barré syndrome in children: clinical course, electrodiagnosis, and prognosis |journal=Muscle Nerve |volume=15 |issue=4 |pages=500–6 |date=April 1992 |pmid=1565119 |doi=10.1002/mus.880150415 |url=}}</ref> | ||
==References== | ==References== | ||
Latest revision as of 16:50, 27 December 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Fahimeh Shojaei, M.D.
Overview
The symptoms of Guillain Barre syndrome typically develop 1 to 3 weeks after the Antecedent Infection. If left untreated, 65% of patients with Guillain Barre syndrome will recover with no permanent disability. 35% of them will not fully recover. 8% of these 35% will die from complication and others will have permanent disabilities.
Common complications of GBS include: respiratory failure, autonomic failure, bulbar pulsy, Deep vein thrombosis, Cardiac arrhythmia, Pain, Urinary retention, Ileus and persistent fatigue
Natural History, Complications, and Prognosis
Natural history
- The symptoms of Guillain Barre syndrome typically develop 1 to 3 weeks after the Antecedent Infection.
- If left untreated, 65% of patients with Guillain Barre syndrome will recover with no permanent disability.
- 35% of them will not fully recover. 8% of these 35% will die from complication and others will have permanent disabilities.
- Treatment will just reduce the recovery period and has no effect on natural history of the disease.
- The first symptoms are lower extremities weakness and paresthesia.[1][2][3]
Complications
- Common complications of GBS include:[4][5]
- respiratory failure
- Autonomic failure
- Bulbar pulsy
- Deep vein thrombosis
- Cardiac arrhythmia
- Pain
- Urinary retention
- Ileus
- Persistent fatigue
Prognosis
- About 65% of patients with GBS will fully recover with no permanent disability.
- 35% of them do not fully recover. 8% of this group will die from GBS complication and others will have permanent disabilities.
- Treatment of GBS just reduce the recovery time and doesn’t affect prognosis.[6]
- Overally, older patients will have worst prognosis in comparison to children who discover very fast.[1][2]
References
- ↑ 1.0 1.1 Hadden RD, Cornblath DR, Hughes RA, Zielasek J, Hartung HP, Toyka KV, Swan AV (November 1998). "Electrophysiological classification of Guillain-Barré syndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group". Ann. Neurol. 44 (5): 780–8. doi:10.1002/ana.410440512. PMID 9818934.
- ↑ 2.0 2.1 Bradshaw DY, Jones HR (April 1992). "Guillain-Barré syndrome in children: clinical course, electrodiagnosis, and prognosis". Muscle Nerve. 15 (4): 500–6. doi:10.1002/mus.880150415. PMID 1565119.
- ↑ Mattle, Heinrich (2017). Fundamentals of neurology : an illustrated guide. Stuttgart New York: Thieme. ISBN 9783131364524.
- ↑ Dornonville de la Cour C, Jakobsen J (January 2005). "Residual neuropathy in long-term population-based follow-up of Guillain-Barré syndrome". Neurology. 64 (2): 246–53. doi:10.1212/01.WNL.0000149521.65474.83. PMID 15668421.
- ↑ Meythaler JM (August 1997). "Rehabilitation of Guillain-Barré syndrome". Arch Phys Med Rehabil. 78 (8): 872–9. PMID 9344309.
- ↑ Rees JH, Thompson RD, Smeeton NC, Hughes RA (January 1998). "Epidemiological study of Guillain-Barré syndrome in south east England". J. Neurol. Neurosurg. Psychiatry. 64 (1): 74–7. PMC 2169900. PMID 9436731.