Gout historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shivam Singla, M.D.[2]
Overview
Historical Perspective
A Brief History of Gout Disease
Gout was first identified by Egyptians around 2640 BC. This is one of the most studied disease do far with more than ! Million people still suffering from the disease till today. Out of them the males are affected the most. The scientist have lot to offer regarding this chronic and debilitating disease. Although it was first recognized by Egyptians but the first clinical description of the disease came from Hippocrates ( 460-370). After a centaury later there is an another scientist named Cappadocian gave a proposal that the gout disease is caused by the toxin in the blood. Which later on given the name of Uric acid in further studies.
Naming the disease
The first person to name the disease was Randolph's of Bocking in early 1200s. The term is usually derived from the Latin word gutta or drop. Till day the variation of terms are seen in different languages all over the world. In English "gout", In French " goutte" and in Italian language it means " gotta" and in German named as "gicht"
In seventeenth centaury the scientist Thomas Sydenham was the fist person to study the aspects of Gout disease in terms of Acute or chronic aspects.. He also help in explaining and differentiating the gout from the other diseases related to different forms of arthritis. The tophi that are uric acid crystal deposits those were fist identified, studied and described these as tiny needle like particles under the microscope by the famous scientist Anton Von Leeuwenhoek. This was later identified as urate crystals by a swedish scientist named as Carl Sc
Understanding gout disease
In the seventeenth century, a number of advances were made in the science of gout.3 Englishman was the first to recognize the chronic and acute aspects of gout disease (hyperuricemia and gout attacks, respectively).3 He also differentiated gout from other forms of arthritis.3 Anton von Leeuwenhock, inventor of the microscope, was the first to examine and describe tophi, finding that it was made up of the tiny, needle-like particles that Swedish chemist Carl Scheele later identified as urate crystals.
Advancing the science
The next major contributor to the study of gout was physician and professor Alfred Baring Garrod.3 He conducted his groundbreaking research at the University of London, demonstrating the relationship between high levels of uric acid in the bloodstream and the development of gout.3 His son, Archibald, carried on his father’s work, making strides in the science of gout disease well into the 20th century.3
Searching for relief for gout disease
Introducing colchicine
Discovering treatments for gout disease
Making gout flares history