Gout diagnostic study of choice

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Monsodium urate crystals under polarising light microscopy[1]


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Diagnostic Study of Choice

  • The diagnostic standard is synovial fluid or tophus aspiration with identification of monosodium urate crystals.
  • Synovial fluid is aspirated from the inflamed joint by careful arthrocentesis.
  • The sample is then analyzed for characteristic negatively birefringent monosodium urate crystals which appear needle-like structures of 1–20 μm in length under polarized microscopy. This is central to confirm the diagnosis of gout. 22303530 18299687
  • It also helps in differentiating gout from acute calcium pyrophosphate crystal arthritis (pseudogout) and septic arthritis.16707533


References

  1. "00214108 | PEIR Digital Library".

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