Gonadoblastoma epidemiology and demographics: Difference between revisions
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{{Gonadoblastoma}} | {{Gonadoblastoma}} | ||
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==Overview== | ==Overview== | ||
The [[prevalence]] of gonadoblastoma varied depend on the chromosomal content, presence or absence of [[mosaicism]], gonadal histology and age of the patient between 15% to 30%. The [[incidence]] of gonadoblastoma varied according to the presence or absence of Y chromosomal content and age of the individual. Patients with [[Turner syndrome]] who have Y chromosomal content either completely or partially can develop gonadoblastoma with an incidence as high as 43%. Phenotypical female with XY gonadal abnormalities have been observed to develop gonadoblastoma by 40% | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
===Incidence=== | ===Incidence=== | ||
*The [[incidence]] of gonadoblastoma varied according to the presence or absence of Y chromosomal content and age of the individual. Patients with [[Turner syndrome]] who have Y chromosomal content either completely or partially can develop gonadoblastoma with an incidence as high as 43%.<ref name="pmid16600779">{{cite journal |vauthors=Brant WO, Rajimwale A, Lovell MA, Travers SH, Furness PD, Sorensen M, Oottamasathien S, Koyle MA |title=Gonadoblastoma and Turner syndrome |journal=J. Urol. |volume=175 |issue=5 |pages=1858–60 |date=May 2006 |pmid=16600779 |doi=10.1016/S0022-5347(05)00932-8 |url=}}</ref> Phenotypical female with XY gonadal abnormalities have been observed to develop gonadoblastoma by 40%.<ref name="978-1-4557-4858-7">{{cite book | last = Sperling | first = M | title = Pediatric endocrinology | publisher = Elsevier/Saunders | location = Philadelphia, PA | year = 2014 | isbn = 978-1-4557-4858-7 }}</ref> | |||
*The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide. | *The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide. | ||
*In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide. | *In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide. | ||
===Prevalence=== | ===Prevalence=== | ||
*The [[prevalence]] of gonadoblastoma varied depend on the chromosomal content, presence or absence of [[mosaicism]], gonadal histology and age of the patient between 15% to 30%.<ref name="urlYen & Jaffes Reproductive Endocrinology | ScienceDirect">{{cite web |url=https://www.sciencedirect.com/book/9781455727582/yen-and-jaffes-reproductive-endocrinology#book-info |title=Yen & Jaffe's Reproductive Endocrinology | ScienceDirect |format= |work= |accessdate=}}</ref> | |||
*The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide. | *The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide. | ||
*In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide. | *In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide. | ||
*The prevalence of [disease/malignancy] is estimated to be [number] cases annually. | *The prevalence of [disease/malignancy] is estimated to be [number] cases annually. | ||
===Age=== | ===Age=== | ||
*Patients of all age groups may develop | *Patients of all age groups may develop gonadoblastoma. | ||
Gonadoblastoma affects individuals of any age but tends to present at a greater extent prior to 15 years of age. it commonly originated from dysgenetic gonad but has been seen in women with normal ovary and karyotypes, although rarely. Since this tumor affects gonads, there is no genotype-phenotype correlations. The majority of affected individuals appear phenotypically female, but in reality, they are intersex. <ref name="pmid4193741">{{cite journal| author=Scully RE| title=Gonadoblastoma. A review of 74 cases. | journal=Cancer | year= 1970 | volume= 25 | issue= 6 | pages= 1340-56 | pmid=4193741 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4193741 }}</ref> | |||
*The incidence of [disease name] increases with age; the median age at diagnosis is [#] years. | *The incidence of [disease name] increases with age; the median age at diagnosis is [#] years. | ||
*[Disease name] commonly affects individuals younger than/older than [number of years] years of age. | *[Disease name] commonly affects individuals younger than/older than [number of years] years of age. | ||
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===Race=== | ===Race=== | ||
*There is no racial predilection to | *There is no racial predilection to gonadoblastoma. | ||
===Gender=== | ===Gender=== | ||
The majority of affected patients (80%) are phenotypically women. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 14:20, 13 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]
Overview
The prevalence of gonadoblastoma varied depend on the chromosomal content, presence or absence of mosaicism, gonadal histology and age of the patient between 15% to 30%. The incidence of gonadoblastoma varied according to the presence or absence of Y chromosomal content and age of the individual. Patients with Turner syndrome who have Y chromosomal content either completely or partially can develop gonadoblastoma with an incidence as high as 43%. Phenotypical female with XY gonadal abnormalities have been observed to develop gonadoblastoma by 40%
Epidemiology and Demographics
Incidence
- The incidence of gonadoblastoma varied according to the presence or absence of Y chromosomal content and age of the individual. Patients with Turner syndrome who have Y chromosomal content either completely or partially can develop gonadoblastoma with an incidence as high as 43%.[1] Phenotypical female with XY gonadal abnormalities have been observed to develop gonadoblastoma by 40%.[2]
- The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
- In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
Prevalence
- The prevalence of gonadoblastoma varied depend on the chromosomal content, presence or absence of mosaicism, gonadal histology and age of the patient between 15% to 30%.[3]
- The incidence/prevalence of [disease name] is approximately [number range] per 100,000 individuals worldwide.
- In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
- The prevalence of [disease/malignancy] is estimated to be [number] cases annually.
Age
- Patients of all age groups may develop gonadoblastoma.
Gonadoblastoma affects individuals of any age but tends to present at a greater extent prior to 15 years of age. it commonly originated from dysgenetic gonad but has been seen in women with normal ovary and karyotypes, although rarely. Since this tumor affects gonads, there is no genotype-phenotype correlations. The majority of affected individuals appear phenotypically female, but in reality, they are intersex. [4]
- The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.
- [Disease name] commonly affects individuals younger than/older than [number of years] years of age.
- [Chronic disease name] is usually first diagnosed among [age group].
- [Acute disease name] commonly affects [age group].
Race
- There is no racial predilection to gonadoblastoma.
Gender
The majority of affected patients (80%) are phenotypically women.
References
- ↑ Brant WO, Rajimwale A, Lovell MA, Travers SH, Furness PD, Sorensen M, Oottamasathien S, Koyle MA (May 2006). "Gonadoblastoma and Turner syndrome". J. Urol. 175 (5): 1858–60. doi:10.1016/S0022-5347(05)00932-8. PMID 16600779.
- ↑ Sperling, M (2014). Pediatric endocrinology. Philadelphia, PA: Elsevier/Saunders. ISBN 978-1-4557-4858-7.
- ↑ "Yen & Jaffe's Reproductive Endocrinology | ScienceDirect".
- ↑ Scully RE (1970). "Gonadoblastoma. A review of 74 cases". Cancer. 25 (6): 1340–56. PMID 4193741.