Glioma classification: Difference between revisions

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Latest revision as of 23:37, 26 November 2017

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2], Sujit Routray, M.D. [3]

Overview

Glioma may be classified into several subtypes based on the type of cell (ependymoma, astrocytoma, oligodendroglioma, and mixed gliomas), grade (low-grade and high-grade gliomas), and location (infratentorial and supratentorial).^[1]

Classification

Glioma may be classified into several subtypes based on the type of cell, grade, and location.^[1]

1. Based on the type of cell

Glioma may be classified according to the type of cell into four subtypes:^[1]

Ependymomas — ependymal cells
Astrocytomas — astrocytes
Oligodendrogliomas — oligodendrocytes
Mixed gliomas (oligoastrocytomas) — cells from different types of glia

2. Based on the grade

Glioma may be classified according to the grade into two subtypes:^[1]

Low-grade gliomas are well-differentiated tumors. These are benign tumors.
High-grade gliomas are undifferentiated or anaplastic tumors. These are malignant tumors.

WHO grading system for astrocytomas


Grade	Type of tumor

WHO grade 1	Pilocytic astrocytoma
WHO grade 2	Low-grade astrocytoma
WHO grade 3	Anaplastic astrocytoma
WHO grade 4	Glioblastoma multiforme

3. Based on the location

Glioma may be classified according to the location into two subtypes:^[1]

Infratentorial: mostly in children (70%)
Supratentorial: mostly in adults (70%)

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Classification of glioma. Wikipedia. https://en.wikipedia.org/wiki/Glioma

Template:WikiDoc Sources

[ddd-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Classification of glioma. Wikipedia. https://en.wikipedia.org/wiki/Glioma

[1]

@@ Line 1: / Line 1: @@
 {{Glioma}}
-{{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}}
+{{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}}, {{SR}}
 ==Overview==
-Glioma may be classified according to the type of cell into 4 subtypes: [[Ependymoma]], [[Astrocytoma]], [[Oligodendroglioma]], and Mixed glioma. Also, it may be classified according to the grade into 2 subtypes: low-grade and high-grade. And according to the location, glioma can be classified  into [[infratentorial]] glioma and [[supratentorial]] glioma.
+Glioma may be classified into several subtypes based on the type of cell (ependymoma, astrocytoma, oligodendroglioma, and mixed gliomas), grade (low-grade and high-grade gliomas), and location (infratentorial and supratentorial).<ref name=ddd>Classification of glioma. Wikipedia. https://en.wikipedia.org/wiki/Glioma</ref>
 ==Classification==
-===By type of cell===
+Glioma may be classified into several subtypes based on the type of cell, grade, and location.<ref name=ddd>Classification of glioma. Wikipedia. https://en.wikipedia.org/wiki/Glioma</ref>
-Gliomas are named according to the specific type of cell they most closely resemble.  The main types of gliomas are:
+===1. Based on the type of cell===
+Glioma may be classified according to the type of cell into four subtypes:<ref name=ddd>Classification of glioma. Wikipedia. https://en.wikipedia.org/wiki/Glioma</ref>
 * [[Ependymoma]]s — [[ependymal cell]]s
 * [[Astrocytoma]]s — [[astrocyte]]s
 * [[Oligodendroglioma]]s — [[oligodendrocyte]]s
-* Mixed gliomas, such as [[oligoastrocytomas]], contain cells from different types of glia.
+* Mixed gliomas ([[oligoastrocytomas]]) — cells from different types of [[glia]]
-===By grade===
+===2. Based on the grade===
-Gliomas are further categorized according to their grade, which is determined by [[pathology|pathologic]] evaluation of the tumor.
+Glioma may be classified according to the grade into two subtypes:<ref name=ddd>Classification of glioma. Wikipedia. https://en.wikipedia.org/wiki/Glioma</ref>
+*Low-grade gliomas are well-differentiated tumors. These are [[cancer|benign]] tumors.
+*High-grade gliomas are undifferentiated or [[anaplastic]] tumors. These are [[cancer|malignant]] tumors.
-* '''Low-grade''' gliomas are well-differentiated (not anaplastic);  these are [[cancer|benign]] and portend a better prognosis for the patient.
+'''WHO grading system for astrocytomas'''
-* '''High-grade''' gliomas are undifferentiated or [[anaplastic]];  these are [[cancer|malignant]] and carry a worse prognosis.
-Of numerous grading systems in use, the most common is the [[World Health Organization]] (WHO) grading system for diffuse astrocytoma.  The WHO system assigns a grade from 1 to 4, with 1 being the least aggressive and 4 being the most aggressive.  Various types of astrocytomas are given corresponding WHO grades.
+{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center
+|valign=top|
+|+
+! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Grade}}
+! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Type of tumor}}
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
+WHO grade 1
+| style="padding: 5px 5px; background: #F5F5F5;" |
+*[[Pilocytic astrocytoma]]
+|-
+| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
+WHO grade 2
+| style="padding: 5px 5px; background: #F5F5F5;" |
+*[[Astrocytoma|Low-grade astrocytoma]]
+|-
+| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
+WHO grade 3
+| style="padding: 5px 5px; background: #F5F5F5;" |
+*[[anaplastic|Anaplastic astrocytoma]]
+|-
+| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
+WHO grade 4
+| style="padding: 5px 5px; background: #F5F5F5;" |
+*[[Glioblastoma multiforme]]
+|}
-:'''WHO grading system for astrocytomas'''
+===3. Based on the location===
-:*WHO Grade 1 &mdash; e.g., [[pilocytic astrocytoma]]
+Glioma may be classified according to the location into two subtypes:<ref name=ddd>Classification of glioma. Wikipedia. https://en.wikipedia.org/wiki/Glioma</ref>
-:*WHO Grade 2 &mdash; e.g., diffuse or low-grade astrocytoma
+* [[Infratentorial]]: mostly in children (70%)
-:*WHO Grade 3 &mdash; e.g., [[anaplastic]] ([[cancer|malignant]]) astrocytoma
+* [[Supratentorial]]: mostly in adults (70%)
-:*WHO Grade 4 &mdash; [[glioblastoma multiforme]] (most common glioma in adults)
-===By location===
-The gliomas can also be roughly classified according to their location:
-* [[infratentorial]] : mostly in children (70%)
-* [[supratentorial]] : mostly in adults (70%)
 ==References==
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-[[Category:Oncology]]
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+ [[Category:Up-To-Date]]
+[[Category:Oncology]]
+[[Category:Medicine]]
+[[Category:Neurology]]
+[[Category:Neurosurgery]]