Gestational trophoblastic neoplasia natural history, complications and prognosis: Difference between revisions
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==Natural history== | ==Natural history== | ||
* Patient has early symptoms | * Patient has early symptoms such as [[vaginal bleeding]], passing of tissue resembling a “bunch of grapes” from the vagina, the abdomen may grow at a much faster rate than with a normal pregnancy | ||
* [[ | * [[Nausea]] and [[vomiting]], and absent fetal movement during pregnancy. | ||
* As the tumor grows larger, patient may notice symptoms like lump in the vagina, [[hemoptysis]], [[chest pain]], trouble breathing, [[headache]], [[dizziness]], [[jaundice]], [[paralysis]], [[seizure]], [[dysarthria]], and [[dysphasia]]. | * As the tumor grows larger, patient may notice symptoms like lump in the vagina, [[hemoptysis]], [[chest pain]], trouble breathing, [[headache]], [[dizziness]], [[jaundice]], [[paralysis]], [[seizure]], [[dysarthria]], and [[dysphasia]]. | ||
Revision as of 15:54, 6 November 2015
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Gestational trophoblastic neoplasia Microchapters |
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Differentiating Gestational trophoblastic neoplasia from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]
Overview
Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.[1]
Natural history
- Patient has early symptoms such as vaginal bleeding, passing of tissue resembling a “bunch of grapes” from the vagina, the abdomen may grow at a much faster rate than with a normal pregnancy
- Nausea and vomiting, and absent fetal movement during pregnancy.
- As the tumor grows larger, patient may notice symptoms like lump in the vagina, hemoptysis, chest pain, trouble breathing, headache, dizziness, jaundice, paralysis, seizure, dysarthria, and dysphasia.
Prognosis
- The prognosis for cure of patients with GTDs is good even when the disease has spread to distant organs, especially when only the lungs are involved.[1]
- The probability of cure depends on the following:
- Histologic type (invasive mole or choriocarcinoma)
- Extent of spread of the disease/largest tumor size
- Level of serum beta-hCG
- Duration of disease from the initial pregnancy event to start of treatment
- Number and specific sites of metastasis
- Nature of antecedent pregnancy
- Extent of prior treatment
Complications
- Recurrence
- Anemia
References
- ↑ 1.0 1.1 General Information About Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq Accessed on October 14, 2015