Gestational trophoblastic neoplasia natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good. | Depending on the extent of the [[tumor]] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.<ref name= abc> General Information About Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq Accessed on October 14, 2015</ref> | ||
==Natural history== | ==Natural history== | ||
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* The prognosis for cure of patients with GTDs is good even when the disease has spread to distant organs, especially when only the lungs are involved.<ref name= abc> General Information About Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq Accessed on October 14, 2015</ref> | * The prognosis for cure of patients with GTDs is good even when the disease has spread to distant organs, especially when only the lungs are involved.<ref name= abc> General Information About Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq Accessed on October 14, 2015</ref> | ||
* The probability of cure depends on the following: | * The probability of cure depends on the following: | ||
:* Histologic type (invasive mole or choriocarcinoma) | :* [[Histologic]] type (invasive mole or choriocarcinoma) | ||
:* Extent of spread of the disease/largest tumor size | :* Extent of spread of the disease/largest tumor size | ||
:* Level of serum beta-hCG | :* Level of serum beta-hCG | ||
:* Duration of disease from the initial pregnancy event to start of treatment | :* Duration of disease from the initial [[pregnancy]] event to start of treatment | ||
:* Number and specific sites of | :* Number and specific sites of [[metastasis]] | ||
:* Nature of antecedent pregnancy | :* Nature of antecedent pregnancy | ||
:* Extent of prior treatment | :* Extent of prior treatment | ||
| Line 23: | Line 23: | ||
==Complications== | ==Complications== | ||
* Recurrence | * Recurrence | ||
* Anemia | *[[ Anemia]] | ||
==References== | ==References== | ||
Revision as of 19:54, 15 October 2015
Template:Choriocarcinoma Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.[1]
Natural history
- Patient has early symptoms like vaginal bleeding, passing of tissue resembling a “bunch of grapes” from the vagina, the abdomen may grow at a much faster rate than with a normal pregnancy
- nausea and vomiting, and absent fetal movement during pregnancy.
- As the tumor grows larger, patient may notice symptoms like lump in the vagina, hemoptysis, chest pain, trouble breathing, headache, dizziness, jaundice, paralysis, seizure, dysarthria, and dysphasia.
Prognosis
- The prognosis for cure of patients with GTDs is good even when the disease has spread to distant organs, especially when only the lungs are involved.[1]
- The probability of cure depends on the following:
- Histologic type (invasive mole or choriocarcinoma)
- Extent of spread of the disease/largest tumor size
- Level of serum beta-hCG
- Duration of disease from the initial pregnancy event to start of treatment
- Number and specific sites of metastasis
- Nature of antecedent pregnancy
- Extent of prior treatment
Complications
- Recurrence
- Anemia
References
- ↑ 1.0 1.1 General Information About Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq Accessed on October 14, 2015