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{{Generalized anxiety disorder}} | {{Generalized anxiety disorder}} | ||
{{CMG}} {{AE}} {{I.D.}} | {{CMG}} {{AE}} {{I.D.}} | ||
==Overview== | |||
In the National Comorbidity Survey (2005), 58% of patients diagnosed with [[Clinical depression|major depression]] were found to have an anxiety disorder. Accumulating evidence indicates that patients with comorbid depression and anxiety tend to have greater illness severity and a lower treatment response than those with either disorder alone. In addition, social function and quality of life are more greatly impaired. Approximately one-quarter of the patients with generalized anxiety disorder, will develop [[panic disorder]]. | |||
==Natural History, Complications and Prognosis== | ==Natural History, Complications and Prognosis== | ||
In the National Comorbidity Survey (2005), 58% of patients diagnosed with [[Clinical depression|major depression]] were found to have an anxiety disorder; among these patients, the rate of comorbidity with GAD was 17.2%, and with [[panic disorder]], 9.9%. Patients with a diagnosed anxiety disorder also had high rates of comorbid depression, including 22.4% of patients with [[social phobia]], 9.4% with [[agoraphobia]], and 2.3% with panic disorder. For many, the symptoms of both depression and anxiety are not severe enough (i.e. are subsyndromal) to justify a primary diagnosis of either major depressive disorder (MDD) or an anxiety disorder. | *In the National Comorbidity Survey (2005), 58% of patients diagnosed with [[Clinical depression|major depression]] were found to have an anxiety disorder; among these patients, the rate of comorbidity with GAD was 17.2%, and with [[panic disorder]], 9.9%. | ||
*Patients with a diagnosed anxiety disorder also had high rates of comorbid depression, including 22.4% of patients with [[social phobia]], 9.4% with [[agoraphobia]], and 2.3% with panic disorder.<ref name="pmid17338599">{{cite journal| author=Morissette SB, Tull MT, Gulliver SB, Kamholz BW, Zimering RT| title=Anxiety, anxiety disorders, tobacco use, and nicotine: a critical review of interrelationships. | journal=Psychol Bull | year= 2007 | volume= 133 | issue= 2 | pages= 245-72 | pmid=17338599 | doi=10.1037/0033-2909.133.2.245 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17338599 }} </ref> | |||
Patients can also be categorized as having mixed anxiety-depressive disorder, and they are at significantly increased risk of developing full-blown depression or anxiety. Appropriate treatment is necessary to alleviate symptoms and prevent the emergence of more serious disease.{{ | **For many, the symptoms of both depression and anxiety are not severe enough (i.e. are subsyndromal) to justify a primary diagnosis of either major depressive disorder (MDD) or an anxiety disorder. | ||
*Patients can also be categorized as having mixed anxiety-depressive disorder, and they are at significantly increased risk of developing full-blown depression or anxiety. Appropriate treatment is necessary to alleviate symptoms and prevent the emergence of more serious disease.<ref>{{cite journal |vauthors=Kessler RC, Keller MB, Wittchen HU |title=The epidemiology of generalized anxiety disorder |journal=Psychiatr. Clin. North Am. |volume=24 |issue=1 |pages=19–39 |date=March 2001 |pmid=11225507 |doi= |url=}}</ref> | |||
Accumulating evidence indicates that patients with comorbid depression and anxiety tend to have greater illness severity and a lower treatment response than those with either disorder alone. | *Accumulating evidence indicates that patients with comorbid depression and anxiety tend to have greater illness severity and a lower treatment response than those with either disorder alone. In addition, social function and quality of life are more greatly impaired. | ||
**In addition to coexisting with depression, research shows that GAD often coexists with [[substance abuse]] or other conditions associated with [[Stress (medicine)|stress]], such as [[irritable bowel syndrome]]. | |||
In addition to coexisting with depression, research shows that GAD often coexists with [[substance abuse]] or other conditions associated with [[Stress (medicine)|stress]], such as [[irritable bowel syndrome]]. | *Patients with physical symptoms such as [[insomnia]] or [[headache]]s should also tell their doctors about their feelings of worry and tension.<ref name="pmid20171328">{{cite journal| author=Newman MG, Przeworski A, Fisher AJ, Borkovec TD| title=Diagnostic comorbidity in adults with generalized anxiety disorder: impact of comorbidity on psychotherapy outcome and impact of psychotherapy on comorbid diagnoses. | journal=Behav Ther | year= 2010 | volume= 41 | issue= 1 | pages= 59-72 | pmid=20171328 | doi=10.1016/j.beth.2008.12.005 | pmc=2827339 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20171328 }} </ref> | ||
**This will help the patient's health care provider to recognize whether the person is suffering from GAD. | |||
*Approximately one-quarter of the patients with generalized anxiety disorder, will develop [[panic disorder]]. | *Approximately one-quarter of the patients with generalized anxiety disorder, will develop [[panic disorder]].<ref name="pmid24419039">{{cite journal| author=Shalev I, Moffitt TE, Braithwaite AW, Danese A, Fleming NI, Goldman-Mellor S et al.| title=Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder. | journal=Mol Psychiatry | year= 2014 | volume= 19 | issue= 11 | pages= 1163-70 | pmid=24419039 | doi=10.1038/mp.2013.183 | pmc=4098012 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24419039 }} </ref> | ||
==References== | ==References== |
Latest revision as of 22:25, 29 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Irfan Dotani
Overview
In the National Comorbidity Survey (2005), 58% of patients diagnosed with major depression were found to have an anxiety disorder. Accumulating evidence indicates that patients with comorbid depression and anxiety tend to have greater illness severity and a lower treatment response than those with either disorder alone. In addition, social function and quality of life are more greatly impaired. Approximately one-quarter of the patients with generalized anxiety disorder, will develop panic disorder.
Natural History, Complications and Prognosis
- In the National Comorbidity Survey (2005), 58% of patients diagnosed with major depression were found to have an anxiety disorder; among these patients, the rate of comorbidity with GAD was 17.2%, and with panic disorder, 9.9%.
- Patients with a diagnosed anxiety disorder also had high rates of comorbid depression, including 22.4% of patients with social phobia, 9.4% with agoraphobia, and 2.3% with panic disorder.[1]
- For many, the symptoms of both depression and anxiety are not severe enough (i.e. are subsyndromal) to justify a primary diagnosis of either major depressive disorder (MDD) or an anxiety disorder.
- Patients can also be categorized as having mixed anxiety-depressive disorder, and they are at significantly increased risk of developing full-blown depression or anxiety. Appropriate treatment is necessary to alleviate symptoms and prevent the emergence of more serious disease.[2]
- Accumulating evidence indicates that patients with comorbid depression and anxiety tend to have greater illness severity and a lower treatment response than those with either disorder alone. In addition, social function and quality of life are more greatly impaired.
- In addition to coexisting with depression, research shows that GAD often coexists with substance abuse or other conditions associated with stress, such as irritable bowel syndrome.
- Patients with physical symptoms such as insomnia or headaches should also tell their doctors about their feelings of worry and tension.[3]
- This will help the patient's health care provider to recognize whether the person is suffering from GAD.
- Approximately one-quarter of the patients with generalized anxiety disorder, will develop panic disorder.[4]
References
- ↑ Morissette SB, Tull MT, Gulliver SB, Kamholz BW, Zimering RT (2007). "Anxiety, anxiety disorders, tobacco use, and nicotine: a critical review of interrelationships". Psychol Bull. 133 (2): 245–72. doi:10.1037/0033-2909.133.2.245. PMID 17338599.
- ↑ Kessler RC, Keller MB, Wittchen HU (March 2001). "The epidemiology of generalized anxiety disorder". Psychiatr. Clin. North Am. 24 (1): 19–39. PMID 11225507.
- ↑ Newman MG, Przeworski A, Fisher AJ, Borkovec TD (2010). "Diagnostic comorbidity in adults with generalized anxiety disorder: impact of comorbidity on psychotherapy outcome and impact of psychotherapy on comorbid diagnoses". Behav Ther. 41 (1): 59–72. doi:10.1016/j.beth.2008.12.005. PMC 2827339. PMID 20171328.
- ↑ Shalev I, Moffitt TE, Braithwaite AW, Danese A, Fleming NI, Goldman-Mellor S; et al. (2014). "Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder". Mol Psychiatry. 19 (11): 1163–70. doi:10.1038/mp.2013.183. PMC 4098012. PMID 24419039.