GNMT

Glycine N-methyltransferase
PDB rendering based on 1bhj.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1bhj​, 1d2c​, 1d2g​, 1d2h​, 1kia​, 1nbh​, 1nbi​, 1r74​, 1r8x​, 1r8y​, 1xva​, 2azt​, 2idj​, 2idk​
Identifiers
Symbols	GNMT ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7741
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glycine N-methyltransferase, also known as GNMT, is a human gene.

Glycine N-methyltransferase (GNMT; EC 2.1.1.20) catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. The enzyme was first described by Blumenstein and Williams (1960) in guinea pig liver. GNMT acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine (AdoHcy) and participates in the detoxification pathway in liver cells.[supplied by OMIM]

Further reading

• Wagner C, Decha-Umphai W, Corbin J (1989). "Phosphorylation modulates the activity of glycine N-methyltransferase, a folate binding protein. In vitro phosphorylation is inhibited by the natural folate ligand". J. Biol. Chem. 264 (16): 9638–42. PMID 2722853.CS1 maint: Multiple names: authors list (link)
• Mudd SH, Ebert MH, Scriver CR (1980). "Labile methyl group balances in the human: the role of sarcosine". Metab. Clin. Exp. 29 (8): 707–20. PMID 6157075.CS1 maint: Multiple names: authors list (link)
• Bhat R, Bresnick E (1997). "Glycine N-methyltransferase is an example of functional diversity. Role as a polycyclic aromatic hydrocarbon-binding receptor". J. Biol. Chem. 272 (34): 21221–6. PMID 9261130.
• Chen YM, Shiu JY, Tzeng SJ; et al. (1998). "Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma". Int. J. Cancer. 75 (5): 787–93. PMID 9495250.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen YM, Chen LY, Wong FH; et al. (2000). "Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene". Genomics. 66 (1): 43–7. doi:10.1006/geno.2000.6188. PMID 10843803.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mudd SH, Cerone R, Schiaffino MC; et al. (2002). "Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia". J. Inherit. Metab. Dis. 24 (4): 448–64. PMID 11596649.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luka Z, Cerone R, Phillips JA; et al. (2002). "Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism". Hum. Genet. 110 (1): 68–74. doi:10.1007/s00439-001-0648-4. PMID 11810299.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tseng TL, Shih YP, Huang YC; et al. (2003). "Genotypic and phenotypic characterization of a putative tumor susceptibility gene, GNMT, in liver cancer". Cancer Res. 63 (3): 647–54. PMID 12566309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Møller MT, Samari HR, Fengsrud M; et al. (2003). "Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes". Biochem. J. 373 (Pt 2): 505–13. doi:10.1042/BJ20030502. PMID 12697024.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luka Z, Wagner C (2004). "Effect of naturally occurring mutations in human glycine N-methyltransferase on activity and conformation". Biochem. Biophys. Res. Commun. 312 (4): 1067–72. PMID 14651980.
• Augoustides-Savvopoulou P, Luka Z, Karyda S; et al. (2004). "Glycine N -methyltransferase deficiency: a new patient with a novel mutation". J. Inherit. Metab. Dis. 26 (8): 745–59. doi:10.1023/B:BOLI.0000009978.17777.33. PMID 14739680.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beagle B, Yang TL, Hung J; et al. (2006). "The glycine N-methyltransferase (GNMT) 1289 C->T variant influences plasma total homocysteine concentrations in young women after restricting folate intake". J. Nutr. 135 (12): 2780–5. PMID 16317120.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luka Z, Pakhomova S, Luka Y; et al. (2007). "Destabilization of human glycine N-methyltransferase by H176N mutation". Protein Sci. 16 (9): 1957–64. doi:10.1110/ps.072921507. PMID 17660255.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)