GADD45B

Growth arrest and DNA-damage-inducible, beta
Identifiers
Symbols	GADD45B ; DKFZP566B133; GADD45BETA; MYD118
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7433
Gene ontology Molecular function Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Growth arrest and DNA-damage-inducible, beta, also known as GADD45B, is a human gene.

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.

See also

• Gadd45

Further reading

• Abdollahi A, Lord KA, Hoffman-Liebermann B, Liebermann DA (1991). "Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines". Oncogene. 6 (1): 165–7. PMID 1899477.CS1 maint: Multiple names: authors list (link)
• Vairapandi M, Balliet AG, Fornace AJ; et al. (1996). "The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1". Oncogene. 12 (12): 2579–94. PMID 8700517.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koonin EV (1997). "Cell cycle and apoptosis: possible roles of Gadd45 and MyD118 proteins inferred from their homology to ribosomal proteins". J. Mol. Med. 75 (4): 236–8. PMID 9151207.
• Takekawa M, Saito H (1998). "A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK". Cell. 95 (4): 521–30. PMID 9827804.
• Sakaue M, Adachi H, Jetten AM (1999). "Post-transcriptional regulation of MyD118 and GADD45 in human lung carcinoma cells during 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2- naphthalene carboxylic acid-induced apoptosis". Mol. Pharmacol. 55 (4): 668–76. PMID 10101024.CS1 maint: Multiple names: authors list (link)
• Gong R, Yu L, Zhang H; et al. (2000). "Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping". Cytogenet. Cell Genet. 88 (1–2): 95–6. PMID 10773677.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vairapandi M, Azam N, Balliet AG; et al. (2000). "Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control". J. Biol. Chem. 275 (22): 16810–9. PMID 10828065.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yi YW, Kim D, Jung N; et al. (2000). "Gadd45 family proteins are coactivators of nuclear hormone receptors". Biochem. Biophys. Res. Commun. 272 (1): 193–8. PMID 10872826.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang Q, Manicone A, Coursen JD; et al. (2001). "Identification of a functional domain in a GADD45-mediated G2/M checkpoint". J. Biol. Chem. 275 (47): 36892–8. doi:10.1074/jbc.M005319200. PMID 10973963.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wan Y, Wang Z, Shao Y; et al. (2001). "UV-induced expression of GADD45 is mediated by an oxidant sensitive pathway in cultured human keratinocytes and in human skin in vivo". Int. J. Mol. Med. 6 (6): 683–8. PMID 11078829.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kovalsky O, Lung FD, Roller PP, Fornace AJ (2001). "Oligomerization of human Gadd45a protein". J. Biol. Chem. 276 (42): 39330–9. doi:10.1074/jbc.M105115200. PMID 11498536.CS1 maint: Multiple names: authors list (link)
• Vairapandi M, Balliet AG, Hoffman B, Liebermann DA (2002). "GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress". J. Cell. Physiol. 192 (3): 327–38. doi:10.1002/jcp.10140. PMID 12124778.CS1 maint: Multiple names: authors list (link)
• Jin R, De Smaele E, Zazzeroni F; et al. (2002). "Regulation of the gadd45beta promoter by NF-kappaB". DNA Cell Biol. 21 (7): 491–503. doi:10.1089/104454902320219059. PMID 12162804.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chung HK, Yi YW, Jung NC; et al. (2003). "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle". J. Biol. Chem. 278 (30): 28079–88. doi:10.1074/jbc.M212835200. PMID 12716909.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qiu W, David D, Zhou B; et al. (2003). "Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma". Am. J. Pathol. 162 (6): 1961–74. PMID 12759252.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zazzeroni F, Papa S, Algeciras-Schimnich A; et al. (2004). "Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis". Blood. 102 (9): 3270–9. doi:10.1182/blood-2003-03-0689. PMID 12855571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Major MB, Jones DA (2004). "Identification of a gadd45beta 3' enhancer that mediates SMAD3- and SMAD4-dependent transcriptional induction by transforming growth factor beta". J. Biol. Chem. 279 (7): 5278–87. doi:10.1074/jbc.M311517200. PMID 14630914.
• Papa S, Zazzeroni F, Bubici C; et al. (2004). "Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2". Nat. Cell Biol. 6 (2): 146–53. doi:10.1038/ncb1093. PMID 14743220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)