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{{Infobox_Disease |
{{Follicular lymphoma}}
  Name          = {{PAGENAME}} |
  Image          = |
  Caption        = |
  DiseasesDB    = |
  ICD10          = {{ICD10|C|82||c|81}} |
  ICD9          = {{ICD9|202.0}}  |
  ICDO          = M9690/3 |
  OMIM          = |
  MedlinePlus    = |
  MeshID        = D008224 |
}}
{{SI}}
{{CMG}}


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'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
==Overview==
'''Follicular lymphoma''' (FL) is the most common of the indolent [[non-Hodgkin's lymphoma]]s. It is defined as a [[lymphoma]] of [[follicle]] center [[B-cells]] (centrocytes and centroblasts), which has at least a partially follicular pattern. It is positive for [[CD10]].<ref>[http://pleiad.umdnj.edu/hemepath/follicular/follicular.html Overview at University of Medicine and Dentistry of New Jersey]</ref>


==Pathophysiology==
{{CMG}}; {{AE}} {{AS}} {{JSS}}
The [[tumor]] is composed of follicle center cells, usually a mixture of centrocytes (cleaved follicle center cells, "small cells") and centroblasts (large noncleaved follicle center cells, "[[large cells]]"). Centrocytes typically predominate; centroblasts are usually in the minority, but by definition are always present. Rare lymphomas with a follicular growth pattern consist almost entirely of centroblasts. Occasional cases may show [[plasmacytoid]] differentiation of foci of [[marginal zone]] or [[monocytoid]] B-cells.


==Causes==
{{SK}} FL; Centroblastic and centrocytic lymphoma; Brill-Symmers Disease.
A [[translocation]] between [[chromosome]] 14 and 18 results in the overexpression of the ''bcl''2 [[gene]]. This overexpression causes a blockage of [[apoptosis]], or programmed cell death. This translocation has been associated with the development of Follicular lymphoma.
 
==[[Follicular lymphoma overview|Overview]]==
 
==[[Follicular lymphoma historical perspective|Historical Perspective]]==
 
==[[Follicular lymphoma classification|Classification]]==
 
==[[Follicular lymphoma pathophysiology|Pathophysiology]]==
 
==[[Follicular lymphoma causes|Causes]]==
 
==[[Follicular lymphoma differential diagnosis|Differentiating Follicular lymphoma from other Diseases]]==
 
==[[Follicular lymphoma epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Follicular lymphoma risk factors|Risk Factors]]==
 
==[[Follicular lymphoma screening|Screening]]==
 
==[[Follicular lymphoma natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 
==Diagnosis==
[[Follicular  lymphoma staging|Staging]] | [[Follicular lymphoma history and symptoms|History and Symptoms]] | [[Follicular lymphoma physical examination|Physical Examination]] | [[Follicular lymphoma laboratory findings|Laboratory Findings]] | [[Follicular lymphoma chest x ray|Chest X Ray]] | [[Follicular lymphoma CT|CT]] | [[Follicular lymphoma MRI|MRI]] | [[Follicular lymphoma ultrasound|Ultrasound]] | [[Follicular lymphoma biopsy|Biopsy]] | [[Follicular lymphoma other imaging findings|Other Imaging Findings]] | [[Follicular lymphoma other diagnostic studies|Other Diagnostic Studies]]


==Treatment==
==Treatment==
There is no consensus regarding the best treatment [[algorithm]], but watch-and-wait policies, [[alkylators]], [[anthracycline]]-containing regimens (eg. [[CHOP]]), [[rituximab]], [[autologous]] and [[allogenic]] [[hematopoietic stem cell transplantation]] have all been applied. The disease is regarded as incurable (although allogenic stem cell transplantation may be curative, the [[death|mortality]] from the procedure is too high to be a first line option). The exception is localized disease, which can be cured by local [[irradiation]]. The typical pattern is one of good responses from treatment, followed by relapses some years later. [[Median]] survival is around 10 years, but the range is wide, from less than one year, to more than 20 years. Some patients may never need treatment.
[[Follicular lymphoma medical therapy|Medical Therapy]] | [[Follicular lymphoma surgery|Surgery]] | [[Follicular lymphoma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Follicular lymphoma future or investigational therapies|Future or Investigational Therapies]]


==References==
==Case Studies==
<references/>
[[Follicular lymphoma case study one|Case #1]]


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Latest revision as of 01:25, 28 December 2018

Follicular lymphoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Follicular lymphoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-Ray

CT scan

MRI

Echocardiography or Ultrasound

Biopsy

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Follicular lymphoma On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

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American Roentgen Ray Society Images of Follicular lymphoma

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X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Follicular lymphoma

CDC on Follicular lymphoma

Follicular lymphoma in the news

Blogs on Follicular lymphoma

Directions to Hospitals Treating Follicular lymphoma

Risk calculators and risk factors for Follicular lymphoma

For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2] Jogeet Singh Sekhon, M.D. [3]

Synonyms and keywords: FL; Centroblastic and centrocytic lymphoma; Brill-Symmers Disease.

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Follicular lymphoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging | History and Symptoms | Physical Examination | Laboratory Findings | Chest X Ray | CT | MRI | Ultrasound | Biopsy | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1


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