Focal segmental glomerulosclerosis laboratory findings: Difference between revisions
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{{Focal segmental glomerulosclerosis}} | {{Focal segmental glomerulosclerosis}} | ||
{{CMG}} | {{CMG}}{{APM}} {{AE}} {{MKK}} | ||
==Overview== | ==Overview== | ||
Initial lab-work up should be directed first towards finding a possible etiology for FSGS. HIV testing in patients with new-onset FSGS, especially those with collapsing variant, is a must in all patient. Additionally, monitoring of disease progression by serum creatinine and proteinuria is equally important. | Initial lab-work up should be directed first towards finding a possible etiology for FSGS. HIV testing in patients with new-onset FSGS, especially those with collapsing variant, is a must in all patient. Additionally, monitoring of disease progression by serum creatinine and proteinuria is equally important. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
A comprehensive lab workup is necessary for all patients with FSGS. Common causes of secondary FSGS, such as HIV, HBV, HCV, and systemic lupus erythematosus (SLE), should also be ruled out. Laboratory findings consistent with the diagnosis of focal segmental glomerulosclerosis include:<ref name="pmid23871408">{{cite journal| author=Beck L, Bomback AS, Choi MJ, Holzman LB, Langford C, Mariani LH et al.|title=KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis.| journal=Am J Kidney Dis | year= 2013 | volume= 62 | issue= 3 | pages= 403-41 | pmid=23871408 |doi=10.1053/j.ajkd.2013.06.002 | pmc= |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23871408 }} </ref><ref name="pmid28242845">{{cite journal |vauthors=Rosenberg AZ, Kopp JB |title=Focal Segmental Glomerulosclerosis |journal=Clin J Am Soc Nephrol |volume=12 |issue=3 |pages=502–517 |date=March 2017 |pmid=28242845 |pmc=5338705 |doi=10.2215/CJN.05960616 |url=}}</ref> | |||
A comprehensive lab | *CBC | ||
* | **Anemia | ||
* | |||
*Lipid profile | *Lipid profile | ||
* | **Hyperlipidemia | ||
*Renal function test | |||
**Increased creatinine levels | |||
**Hypoalbuminemia | |||
*Blood urea nitrogen (BUN) | *Blood urea nitrogen (BUN) | ||
*CD4 count and HIV test | *CD4 count and HIV test | ||
*DNA/PCR for parvovirus B19 | *DNA/PCR for parvovirus B19 | ||
*CMV test | *CMV test | ||
| Line 23: | Line 24: | ||
*c-ANCA and p-ANCA | *c-ANCA and p-ANCA | ||
*Serum protein electrophoresis | *Serum protein electrophoresis | ||
*Urine analysis | |||
**Proteinuria | |||
**Microscopic hematuria | |||
**Dysmorphic red blood cells | |||
**Fatty casts | |||
*Urine | **Microalbuminuria and urinary creatinine | ||
* | **Urine culture | ||
**Urinary protein electrophoresis | |||
* | |||
* | |||
* | |||
* | |||
*Dysmorphic red blood cells | |||
*Fatty casts | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category: | [[Category:Nephrology]] | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Latest revision as of 16:02, 11 June 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [3]
Overview
Initial lab-work up should be directed first towards finding a possible etiology for FSGS. HIV testing in patients with new-onset FSGS, especially those with collapsing variant, is a must in all patient. Additionally, monitoring of disease progression by serum creatinine and proteinuria is equally important.
Laboratory Findings
A comprehensive lab workup is necessary for all patients with FSGS. Common causes of secondary FSGS, such as HIV, HBV, HCV, and systemic lupus erythematosus (SLE), should also be ruled out. Laboratory findings consistent with the diagnosis of focal segmental glomerulosclerosis include:[1][2]
- CBC
- Anemia
- Lipid profile
- Hyperlipidemia
- Renal function test
- Increased creatinine levels
- Hypoalbuminemia
- Blood urea nitrogen (BUN)
- CD4 count and HIV test
- DNA/PCR for parvovirus B19
- CMV test
- Serum complement C3 and C4
- ANA profile
- Titers of antibodies specific for systemic diseases, such as anti-dsDNA
- c-ANCA and p-ANCA
- Serum protein electrophoresis
- Urine analysis
- Proteinuria
- Microscopic hematuria
- Dysmorphic red blood cells
- Fatty casts
- Microalbuminuria and urinary creatinine
- Urine culture
- Urinary protein electrophoresis
References
- ↑ Beck L, Bomback AS, Choi MJ, Holzman LB, Langford C, Mariani LH; et al. (2013). "KDOQI US commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis". Am J Kidney Dis. 62 (3): 403–41. doi:10.1053/j.ajkd.2013.06.002. PMID 23871408.
- ↑ Rosenberg AZ, Kopp JB (March 2017). "Focal Segmental Glomerulosclerosis". Clin J Am Soc Nephrol. 12 (3): 502–517. doi:10.2215/CJN.05960616. PMC 5338705. PMID 28242845.