Filariasis overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Lymphatic Filariasis (Philariasis) is a parasitic and infectious tropical disease, caused by three thread-like parasitic filarial worms called nematode worms, Wuchereria bancrofti, Brugia malayi, and Brugia timori, all transmitted by mosquitoes. It is extremely rare in Western countries. Loa loa is another filarial parasite of humans, transmitted by the deer fly.
Historical Perspective
Filariasis is believed to be found since the 16th century as Jan Huygen Linschoten put an overall idea about the disease when he went to Goa. Moving forward through the 19th century there was many discoveries regarding filariasis and the infective worms and the arthropod vectors. In 1866, the detection of the microfilariae in urine and blood. 10 years later in 1876, Joseph Bancroft discovered the adult worm which is responsible for the infection and named after that as Wuchereria Bancrofti. Through the next years till 1900s more discoveries and description of the life cycles of the worms had been known.[1]
Classification
Filariasis disease can be classified based on the site of infection. It is caused by different types of roundworms that infect particular site in the body. A group of these worms infect the lymphatic vessels causing lymphatic filariasis. Others infect serous cavities and subcutaneous tissues. It can be also classified into acute and chronic filariasis.
Pathophysiology
Filariasis infection occurs when a larva carrying mosquito bites individual skin introducing these larvae onto the skin. The larvae then enter the patient blood through the skin wound and spread to the different sites of infection either lymphatic vessels, subcutaneous tissues or the serous cavities. At those different sites, The larvae tend to mature in a six to twelve months process to be adult filariae which can live up to fifteen years. Reproduction takes place between the male and female adult worms producing microfilariae which are premature organisms with sheath that circulate the blood in case they are settled in the lymphatic vessels. During another blood meal, the mosquito takes up the microfilariae then those microfilariae lose their sheath within two weeks to be larvae that enter the human body when the human is bitten by a mosquito and the cycle restarts again. Pathogenesis of the disease depends on number of factors including immune response of the patient, the number of secondary bacterial infections, the accumulation of the worm antigens, release of Wolbachia bacteria from the worm and the genetic predisposition.[1]
Causes
Filariasis is caused by the parasitic organisms nematodes which are round worms or thread worms that infects mainly lymphatic vessels causing lympphatic filariasis. The three main nematodes that cause lymphatic filariasis are Wuchereria bancrofti, Brugia malayi and Brugia timori. Other nematodes include Loa loa (the eye worm), Mansonella streptocerca, and Onchocerca volvulus that cause subcutaneous filariasis. Mansonella perstans and Mansonella ozzardi cause serous cavity filariasis.[2][1]
Differentiating filariasis from other diseases
Epidemiology and Demographics
Filariasis is endemic in tropical regions of Asia, Africa, Central and South America with 120 million people infected. In endemic areas of the world (e.g., Malaipea in Indonesia), up to 54% of the population may have microfilariae in their blood.[3]
Risk factors
Common risk factors in the development of filariasis are exposure to mosquitoes for long time and getting bitten by them many times and people living in tropical areas for long time.
Screening
Screening has been important to be performed especially among the people of Asian countries like Malaysia, China and India. It is important among people who work in agriculture field which may be home for the infected mosquitoes and vectors so, these people are more vulnerable to get infected. Two known tests for the screening which are dipstick colloidal dye immunoassay and ICT filariasis test kit.
Natural history, complications and prognosis
If left untreated, patients with lymphatic filariasis may progress to develop chronic lymphedema, hydrocele, skin pigmentation, and chyluria. Prognosis is generally good in early cases, but in chronic cases the disease can leave an individual severely disabled with genital damage.
Diagnosis
History and Symptoms
The most spectacular symptom of lymphatic filariasis is elephantiasis—thickening of the skin and underlying tissues—which was the first disease discovered to be transmitted by insects. Elephantiasis is caused when the parasites lodge in the lymphatic system. Elephantiasis affects mainly the lower extremities, whereas ears, mucus membranes, and amputation stumps are rarely affected; however, it depends on the species of filaria. W. bancrofti can affect the legs, arms, vulva, breasts, while Brugia timori rarely affects the genitals.
Physical examination
Laboratory and Findings
The diagnosis is made by identifying microfilariae on a Giemsa stained thick blood film. Blood must be drawn at night, since the microfilaria circulate at night, when their vector, the mosquito, is most likely to bite. There are also PCR assays available for making the diagnosis.
X ray
There are no x ray findings associated with filariasis.
CT scan
MRI
There are no MRI findings associated with filariasis.
Ultrasound
Ultrasound can be used in cases of filariasis to detect the presence of the adult worms in the lymphatics. It is used also in knowing how far the medical therapy is effective. Dilated lymphatic channels and living worm moving showing what is called filarial dance sign are noticed in the ultrasound.[4][5]
Other imaging findings
Other diagnostic findings
Treatment
Medical Therapy
The recommended treatment for patients outside the United States is albendazole (a broad spectrum anthelmintic) combined with ivermectin.[6] A combination of diethylcarbamazine (DEC) and albendazole is also effective. All of these treatments are microfilaricides; they have no effect on the adult worms.
Surgery
Surgery is not the first-line treatment option for patients with filariasis. It is usually reserved for patients with chronic lymphedema with failure of medical treatment and worsened presentation such as lymphatic venous anastomoses, Hydrocelectomy also can be performed for intractable cases of hydrocele.
Primary prevention
There are many primary preventive measures available for filariasis. Wearing appropriate clothing, Avoid outbreaks, Insecticides and Spatial Repellents,Bed nets and Mass drug treatment programs are efficient ways to prevent filariasis.
References
- ↑ 1.0 1.1 1.2 Chandy A, Thakur AS, Singh MP, Manigauha A (2011). "A review of neglected tropical diseases: filariasis". Asian Pac J Trop Med. 4 (7): 581–6. doi:10.1016/S1995-7645(11)60150-8. PMID 21803313.
- ↑ CDC https://www.cdc.gov/parasites/lymphaticfilariasis/epi.html Accessed on June 26, 2017
- ↑ Aupali T, Ismid IS, Wibowo H; et al. (2006). "Estimation of the prevalence of lymphatic filariasis by a pool screen PCR assay using blood spots collected on filter paper". Tran R Soc Trop Med Hyg. 100 (8): 753&ndash, 9.
- ↑ Dreyer G, Noroes J, Amaral F, Nen A, Medeiros Z, Coutinho A; et al. (1995). "Direct assessment of the adulticidal efficacy of a single dose of ivermectin in bancroftian filariasis". Trans R Soc Trop Med Hyg. 89 (4): 441–3. PMID 7570894.
- ↑ Mand S, Debrah A, Batsa L, Adjei O, Hoerauf A (2004). "Reliable and frequent detection of adult Wuchereria bancrofti in Ghanaian women by ultrasonography". Trop Med Int Health. 9 (10): 1111–4. doi:10.1111/j.1365-3156.2004.01304.x. PMID 15482404.
- ↑ U.S. Centers for Disease Control, Lymphatic Filariasis Treatment, retrieved 2008-07-17