FABP7

Fatty acid binding protein 7, brain
PDB rendering based on 1fdq.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1fdq​, 1fe3​, 1jjx​
Identifiers
Symbols	FABP7 ; B-FABP; BLBP; DKFZp547J2313; FABPB; MRG
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37880
Gene ontology Molecular function Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Fatty acid binding protein 7, brain, also known as FABP7, is a human gene. The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.

Expression of Fabp7 protein in mouse brains at embryonic day 16 (left) and postnatal day 0 (right). At both stages, Fabp7 is strongly expressed in the ventricular zone and radial glia, where neurogenesis is prominent.

Further reading

• Börchers T, Hohoff C, Buhlmann C, Spener F (1997). "Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation". Prostaglandins Leukot. Essent. Fatty Acids. 57 (1): 77–84. PMID 9250612.CS1 maint: Multiple names: authors list (link)
• Xu LZ, Sánchez R, Sali A, Heintz N (1996). "Ligand specificity of brain lipid-binding protein". J. Biol. Chem. 271 (40): 24711–9. PMID 8798739.CS1 maint: Multiple names: authors list (link)
• Young JK, Baker JH, Muller T (1997). "Immunoreactivity for brain-fatty acid binding protein in gomori-positive astrocytes". Glia. 16 (3): 218–26. doi:10.1002/(SICI)1098-1136(199603)16:3<218::AID-GLIA4>3.0.CO;2-Y. PMID 8833192.CS1 maint: Multiple names: authors list (link)
• Shi YE, Ni J, Xiao G; et al. (1997). "Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG". Cancer Res. 57 (15): 3084–91. PMID 9242429.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimizu F, Watanabe TK, Shinomiya H; et al. (1997). "Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP)". Biochim. Biophys. Acta. 1354 (1): 24–8. PMID 9375786.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Godbout R, Bisgrove DA, Shkolny D, Day RS (1998). "Correlation of B-FABP and GFAP expression in malignant glioma". Oncogene. 16 (15): 1955–62. doi:10.1038/sj.onc.1201740. PMID 9591779.CS1 maint: Multiple names: authors list (link)
• Pu L, Igbavboa U, Wood WG; et al. (1999). "Expression of fatty acid binding proteins is altered in aged mouse brain". Mol. Cell. Biochem. 198 (1–2): 69–78. PMID 10497880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Balendiran GK, Schnutgen F, Scapin G; et al. (2000). "Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein". J. Biol. Chem. 275 (35): 27045–54. doi:10.1074/jbc.M003001200. PMID 10854433.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rademacher M, Zimmerman AW, Rüterjans H; et al. (2003). "Solution structure of fatty acid-binding protein from human brain". Mol. Cell. Biochem. 239 (1–2): 61–8. PMID 12479569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miller SJ, Li H, Rizvi TA; et al. (2003). "Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis". Mol. Cell. Biol. 23 (6): 2213–24. PMID 12612091.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sánchez-Font MF, Bosch-Comas A, Gonzàlez-Duarte R, Marfany G (2003). "Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance". Nucleic Acids Res. 31 (11): 2769–77. PMID 12771203.CS1 maint: Multiple names: authors list (link)
• Wang M, Liu YE, Goldberg ID, Shi YE (2004). "Induction of mammary gland differentiation in transgenic mice by the fatty acid-binding protein MRG". J. Biol. Chem. 278 (47): 47319–25. doi:10.1074/jbc.M308131200. PMID 12975368.CS1 maint: Multiple names: authors list (link)
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liang Y, Diehn M, Watson N; et al. (2005). "Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme". Proc. Natl. Acad. Sci. U.S.A. 102 (16): 5814–9. doi:10.1073/pnas.0402870102. PMID 15827123.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liang Y, Bollen AW, Aldape KD, Gupta N (2006). "Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma". BMC Cancer. 6: 97. doi:10.1186/1471-2407-6-97. PMID 16623952.CS1 maint: Multiple names: authors list (link)
• Kaloshi G, Mokhtari K, Carpentier C; et al. (2007). "FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status". J. Neurooncol. 84 (3): 245–8. doi:10.1007/s11060-007-9377-4. PMID 17415524.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)