FABP6

Fatty acid binding protein 6, ileal (gastrotropin)
PDB rendering based on 1o1u.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1o1u​, 1o1v​
Identifiers
Symbols	FABP6 ; I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3; ILLBP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1108
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Fatty acid binding protein 6, ileal (gastrotropin), also known as FABP6, is a human gene.

This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene.

Further reading

• Börchers T, Hohoff C, Buhlmann C, Spener F (1997). "Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation". Prostaglandins Leukot. Essent. Fatty Acids. 57 (1): 77–84. PMID 9250612.CS1 maint: Multiple names: authors list (link)
• Fujita M, Fujii H, Kanda T; et al. (1995). "Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein". Eur. J. Biochem. 233 (2): 406–13. PMID 7588781.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oelkers P, Dawson PA (1995). "Cloning and chromosomal localization of the human ileal lipid-binding protein". Biochim. Biophys. Acta. 1257 (2): 199–202. PMID 7619861.
• Birkenmeier EH, Rowe LB, Crossman MW, Gordon JI (1995). "Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11". Mamm. Genome. 5 (12): 805–6. PMID 7894165.CS1 maint: Multiple names: authors list (link)
• Watanabe K, Hoshi N, Tsuura Y; et al. (1996). "Immunohistochemical distribution of intestinal 15 kDa protein in human tissues". Arch. Histol. Cytol. 58 (3): 303–6. PMID 8527237.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lücke C, Zhang F, Rüterjans H; et al. (1997). "Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein". Structure. 4 (7): 785–800. PMID 8805562.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grober J, Zaghini I, Fujii H; et al. (1999). "Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer". J. Biol. Chem. 274 (42): 29749–54. PMID 10514450.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seibert C, Harteneck C, Ernst OP; et al. (2000). "Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells". Eur. J. Biochem. 266 (3): 911–6. PMID 10583385.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lücke C, Zhang F, Hamilton JA; et al. (2000). "Solution structure of ileal lipid binding protein in complex with glycocholate". Eur. J. Biochem. 267 (10): 2929–38. PMID 10806391.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kurz M, Brachvogel V, Matter H; et al. (2003). "Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures". Proteins. 50 (2): 312–28. doi:10.1002/prot.10289. PMID 12486725.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barley NF, Taylor V, Shaw-Smith CJ; et al. (2004). "Human ileal bile acid-binding protein promoter and the effects of CDX2". Biochim. Biophys. Acta. 1630 (2–3): 138–43. PMID 14654244.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Landrier JF, Thomas C, Grober J; et al. (2005). "The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors". Biochim. Biophys. Acta. 1735 (1): 41–9. doi:10.1016/j.bbalip.2005.05.002. PMID 15936983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bergheim I, Harsch S, Mueller O; et al. (2006). "Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers". J. Lipid Res. 47 (1): 42–50. doi:10.1194/jlr.M500215-JLR200. PMID 16237211.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohmachi T, Inoue H, Mimori K; et al. (2007). "Fatty acid binding protein 6 is overexpressed in colorectal cancer". Clin. Cancer Res. 12 (17): 5090–5. doi:10.1158/1078-0432.CCR-05-2045. PMID 16951225.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fang C, Dean J, Smith JW (2007). "A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma". Cancer Res. 67 (19): 9039–46. doi:10.1158/0008-5472.CAN-06-3690. PMID 17909007.CS1 maint: Multiple names: authors list (link)