Extranodal NK-T-cell lymphoma pathophysiology
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Differentiating Extranodal NK-T-cell lymphoma from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
On gross pathology, anglocentric and angiodestructive pattern of growth with associated geographical necrosis and ulceration are characteristic findings of [disease name]. On microscopic histopathological analysis, medium sized tumor cells and polymorphic infiltrate of nonneoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma.
Genetics
Immunotype
The immunophenotype of NK lymphoma cells is classically positive for CD2, CD56, and cytoplasmic CD3 epsilon. They are negative for surface CD3. Unlike normal NK cells, the tumor cells are usually negative for CD7 and CD16. They express cytotoxic granule associated proteins granzyme B, T-cell restricted intracellular antigen (TIA-1), and perforin.
Gross Pathology
- On gross pathology, anglocentric and angiodestructive pattern of growth with associated geographical necrosis and ulceration are characteristic findings of [disease name].
- Coagulative necrosis and apoptotic bodies are frequently encountered.
Microscopic Pathology
- On microscopic histopathological analysis, medium sized tumor cells and polymorphic infiltrate of nonneoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma.
- The tumor cells are small to medium in size with occasional large and anaplastic forms.
- The lymphoma cells may be admixed with a polymorphic infiltrate of nonneoplastic inflammatory cells including small lymphocytes, plasma cells, histiocytes, and eosinophils.