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* NK cells are CD3 and myloperoxidase negative on their surface.<ref name="HamKo2010">{{cite journal|last1=Ham|first1=Maria Francisca|last2=Ko|first2=Young-Hyeh|title=Natural killer cell neoplasm: biology and pathology|journal=International Journal of Hematology|volume=92|issue=5|year=2010|pages=681–689|issn=0925-5710|doi=10.1007/s12185-010-0738-y}}</ref>
* NK cells are CD3 and myloperoxidase negative on their surface.<ref name="HamKo2010">{{cite journal|last1=Ham|first1=Maria Francisca|last2=Ko|first2=Young-Hyeh|title=Natural killer cell neoplasm: biology and pathology|journal=International Journal of Hematology|volume=92|issue=5|year=2010|pages=681–689|issn=0925-5710|doi=10.1007/s12185-010-0738-y}}</ref>
* NK cells have germline configuration of T-cell receptor and immunoglobulin genes.  
* NK cells have germline configuration of T-cell receptor and immunoglobulin genes.  
*NK cells originate from a bipotent NK/T-progenitor cell so they have a lot in common with T cells.
*


===Immunotype===
===Immunotype===

Revision as of 01:09, 21 August 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2] Sowminya Arikapudi, M.B,B.S. [3]

Overview

Extra nodal NK-T-cell lymphoma, nasal type, can develop in either T cells or natural killer cells, but most often in the NK cells. Natural killer cells are a type of lymphocyte that is closely related to T cells and attack foreign cells. On gross pathology, angiocentric and angiodestructive pattern of growth with associated geographical necrosis and ulceration are characteristic findings of extranodal NK-T-cell lymphoma. On microscopic histopathological analysis, medium-sized tumor cells and polymorphic infiltrate of nonneoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma.[1][2]

Pathophysiology

Physiology

  • NK cells are CD3 and myloperoxidase negative on their surface.[3]
  • NK cells have germline configuration of T-cell receptor and immunoglobulin genes.
  • NK cells originate from a bipotent NK/T-progenitor cell so they have a lot in common with T cells.

Immunotype

  • The immunophenotype of NK lymphoma cells is classically positive for CD2, CD56, and cytoplasmic CD3 epsilon.
  • They are negative for surface CD3. Unlike normal NK cells, the tumor cells are usually negative for CD7 and CD16.
  • They express cytotoxic granule associated proteins granzyme B, T-cell restricted intracellular antigen (TIA-1), and perforin.

Gross Pathology

  • On gross pathology, angiocentric and angiodestructive pattern of growth with associated geographical necrosis and ulceration are characteristic findings of extranodal NK-T-cell lymphoma.
  • Coagulative necrosis and apoptotic bodies are frequently encountered.

Microscopic Pathology

  • On microscopic histopathological analysis, medium sized tumor cells and polymorphic infiltrate of non-neoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma.
  • The tumor cells are small to medium in size with occasional large and anaplastic forms.
  • The lymphoma cells may be admixed with a polymorphic infiltrate of nonneoplastic inflammatory cells including small lymphocytes, plasma cells, histiocytes, and eosinophils.

References

  1. Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016
  2. Extranodal NK/T-cell lymphoma, nasal type. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/extranodal-nk-t-cell-lymphoma-nasal-type/?region=on. Accessed on February 19, 2016
  3. Ham, Maria Francisca; Ko, Young-Hyeh (2010). "Natural killer cell neoplasm: biology and pathology". International Journal of Hematology. 92 (5): 681–689. doi:10.1007/s12185-010-0738-y. ISSN 0925-5710.


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