Extranodal NK-T-cell lymphoma pathophysiology: Difference between revisions

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==Genetics==
==Genetics==
===Immunotype===
===Immunotype===
The immunophenotype of NK lymphoma cells is classically positive for [[CD2]], [[CD56]], and cytoplasmic [[CD3]] epsilon. They are negative for surface [[CD3]]. Unlike normal NK cells, the tumor cells are usually negative for [[CD7]] and [[CD16]]. They express cytotoxic granule associated proteins [[granzyme B]], T-cell restricted intracellular antigen (TIA-1), and [[perforin]].  
* The immunophenotype of NK lymphoma cells is classically positive for [[CD2]], [[CD56]], and cytoplasmic [[CD3]] epsilon.  
* They are negative for surface [[CD3]]. Unlike normal NK cells, the tumor cells are usually negative for [[CD7]] and [[CD16]].
* They express cytotoxic granule associated proteins [[granzyme B]], T-cell restricted intracellular antigen (TIA-1), and [[perforin]].  


==Gross Pathology==
==Gross Pathology==
* On gross pathology, [[anglocentric]] and [[angiodestructive]] pattern of growth with associated geographical [[necrosis]] and [[ulceration]] are characteristic findings of [disease name].  
* On gross pathology, anglocentric and angiodestructive pattern of growth with associated geographical [[necrosis]] and [[ulceration]] are characteristic findings of extranodal NK-T-cell lymphoma.  
* [[Coagulative necrosis]] and [[apoptotic bodies]] are frequently encountered.  
* [[Coagulative necrosis]] and [[apoptotic]] bodies are frequently encountered.  


==Microscopic Pathology==
==Microscopic Pathology==
* On microscopic histopathological analysis, medium sized tumor cells and polymorphic infiltrate of nonneoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma.
* On microscopic histopathological analysis, medium sized tumor cells and polymorphic infiltrate of non-neoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma.
* The tumor cells are small to medium in size with occasional large and anaplastic forms.  
* The tumor cells are small to medium in size with occasional large and anaplastic forms.  
* The lymphoma cells may be admixed with a polymorphic infiltrate of nonneoplastic inflammatory cells including small lymphocytes, plasma cells, histiocytes, and eosinophils.
* The lymphoma cells may be admixed with a polymorphic infiltrate of nonneoplastic inflammatory cells including small [[lymphocytes]], [[plasma cells]], [[histiocytes]], and [[eosinophils]].





Revision as of 15:18, 18 February 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

On gross pathology, anglocentric and angiodestructive pattern of growth with associated geographical necrosis and ulceration are characteristic findings of [disease name]. On microscopic histopathological analysis, medium sized tumor cells and polymorphic infiltrate of nonneoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma.

Genetics

Immunotype

  • The immunophenotype of NK lymphoma cells is classically positive for CD2, CD56, and cytoplasmic CD3 epsilon.
  • They are negative for surface CD3. Unlike normal NK cells, the tumor cells are usually negative for CD7 and CD16.
  • They express cytotoxic granule associated proteins granzyme B, T-cell restricted intracellular antigen (TIA-1), and perforin.

Gross Pathology

  • On gross pathology, anglocentric and angiodestructive pattern of growth with associated geographical necrosis and ulceration are characteristic findings of extranodal NK-T-cell lymphoma.
  • Coagulative necrosis and apoptotic bodies are frequently encountered.

Microscopic Pathology

  • On microscopic histopathological analysis, medium sized tumor cells and polymorphic infiltrate of non-neoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma.
  • The tumor cells are small to medium in size with occasional large and anaplastic forms.
  • The lymphoma cells may be admixed with a polymorphic infiltrate of nonneoplastic inflammatory cells including small lymphocytes, plasma cells, histiocytes, and eosinophils.


References


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