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Revision as of 22:16, 26 November 2017

Endometrial hyperplasia Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

Endometrial hyperplasia may be broadly classified based on histology into simple and complex types. Endometrial hyperplasia may also be classified based on the presence or absence of cellular atypia (hyperplasia with cellular atypia and hyperplasia without cellular atypia).[1][2][3]

Classification

The World Health Organization (WHO) Classification System

The WHO Classification (1994)

  • Endometrial hyperplasia may be classified based on glandular complexity and nuclear atypicality into the following types:[1][2][3]
 
 
 
 
 
 
 
 
 
Endometrial hyperplasia
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Simple
 
 
 
 
 
Complex
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Simple hyperplasia with cellular atypia
 
Simple hyperplasia without cellular atypia
 
Complex hyperplasia with cellular atypia
 
Complex hyperplasia without cellular atypia

The New WHO Classification (2014)

  • The new WHO classification has been proposed to simplify clinical decision making, particularly when making treatment choices.[4]
  • Endometrial hyperplasia may be classified according to new WHO classification (1994) into:
    • Hyperplasia without atypia
    • Atypical hyperplasia/endometrioid intraepithelial neoplasia

The Endometrial Intraepithelial Neoplasia (EIN) Classification

Endometrial changes may be classified according to the International Endometrial Collaborative Group into two types:[5][6]

  • Benign hyperplasia (a hormone dependent diffuse lesion, which is polyclonal)
  • Endometrial intraepithelial neoplasia
    • In the beginning a localized clonal proliferation, which is monoclonal and neoplastic (EIN)
    • With advanced stage, it may become a more diffuse lesion
  • Cancer

References

  1. 1.0 1.1 Scully RE. Histological typing of female genital tract tumours. Springer; 1994.
  2. 2.0 2.1 Endometrial hyperplasia. Radiopedia. http://radiopaedia.org/articles/endometrial-hyperplasia-1 Accessed on March 3, 2016.
  3. 3.0 3.1 Jorizzo JR, Chen MY, Martin D, Dyer RB, Weber TM (2002). "Spectrum of endometrial hyperplasia and its mimics on saline hysterosonography". AJR Am J Roentgenol. 179 (2): 385–9. doi:10.2214/ajr.179.2.1790385. PMID 12130438.
  4. Emons G, Beckmann MW, Schmidt D, Mallmann P, Uterus commission of the Gynecological Oncology Working Group (AGO) (2015). "New WHO Classification of Endometrial Hyperplasias". Geburtshilfe Frauenheilkd. 75 (2): 135–136. doi:10.1055/s-0034-1396256. PMC 4361167. PMID 25797956.
  5. Mutter GL (2000). "Endometrial intraepithelial neoplasia (EIN): will it bring order to chaos? The Endometrial Collaborative Group". Gynecol Oncol. 76 (3): 287–90. doi:10.1006/gyno.1999.5580. PMID 10684697.
  6. Baak JP, Mutter GL (2005). "EIN and WHO94". J Clin Pathol. 58 (1): 1–6. doi:10.1136/jcp.2004.021071. PMC 1770545. PMID 15623473.

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