EIF5B

Eukaryotic translation initiation factor 5B
Identifiers
Symbols	EIF5B ; DKFZp434I036; FLJ10524; IF2; KIAA0741
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5291
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Eukaryotic translation initiation factor 5B, also known as EIF5B, is a human gene.

Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately.

Further reading

• Unbehaun A, Marintchev A, Lomakin IB; et al. (2007). "Position of eukaryotic initiation factor eIF5B on the 80S ribosome mapped by directed hydroxyl radical probing". EMBO J. 26 (13): 3109–23. doi:10.1038/sj.emboj.7601751. PMID 17568775.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hayashi R, Ueda T, Farwell MA, Takeuchi N (2007). "Nuclear respiratory factor 2 activates transcription of human mitochondrial translation initiation factor 2 gene". Mitochondrion. 7 (3): 195–203. doi:10.1016/j.mito.2006.10.005. PMID 17161026.CS1 maint: Multiple names: authors list (link)
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gevaert K, Staes A, Van Damme J; et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID 16097034.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535–40. doi:10.1073/pnas.0437845100. PMID 12569173.CS1 maint: Multiple names: authors list (link)
• Olsen DS, Savner EM, Mathew A; et al. (2003). "Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo". EMBO J. 22 (2): 193–204. doi:10.1093/emboj/cdg030. PMID 12514125.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sørensen HP, Hedegaard J, Sperling-Petersen HU, Mortensen KK (2002). "Remarkable conservation of translation initiation factors: IF1/eIF1A and IF2/eIF5B are universally distributed phylogenetic markers". IUBMB Life. 51 (5): 321–7. PMID 11699879.CS1 maint: Multiple names: authors list (link)
• Wilson SA, Sieiro-Vazquez C, Edwards NJ; et al. (1999). "Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2, and its interaction with HIV-1 matrix". Biochem. J. 342 ( Pt 1): 97–103. PMID 10432305.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee JH, Choi SK, Roll-Mecak A; et al. (1999). "Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2". Proc. Natl. Acad. Sci. U.S.A. 96 (8): 4342–7. PMID 10200264.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. PMID 9872452.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)