EIF1AX

Eukaryotic translation initiation factor 1A, X-linked
PDB rendering based on 1d7q.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1d7q​
Identifiers
Symbols	EIF1AX ; EIF1A; EIF4C; eIF-1A; eIF-4C
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20364
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Eukaryotic translation initiation factor 1A, X-linked, also known as EIF1AX, is a human gene.

This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.

Further reading

• Dever TE, Wei CL, Benkowski LA; et al. (1994). "Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing". J. Biol. Chem. 269 (5): 3212–8. PMID 8106356.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lahn BT, Page DC (1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. PMID 9381176.
• Battiste JL, Pestova TV, Hellen CU, Wagner G (2000). "The eIF1A solution structure reveals a large RNA-binding surface important for scanning function". Mol. Cell. 5 (1): 109–19. PMID 10678173.CS1 maint: Multiple names: authors list (link)
• Choi SK, Olsen DS, Roll-Mecak A; et al. (2000). "Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2". Mol. Cell. Biol. 20 (19): 7183–91. PMID 10982835.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mingot JM, Kostka S, Kraft R; et al. (2001). "Importin 13: a novel mediator of nuclear import and export". EMBO J. 20 (14): 3685–94. doi:10.1093/emboj/20.14.3685. PMID 11447110.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sørensen HP, Hedegaard J, Sperling-Petersen HU, Mortensen KK (2002). "Remarkable conservation of translation initiation factors: IF1/eIF1A and IF2/eIF5B are universally distributed phylogenetic markers". IUBMB Life. 51 (5): 321–7. PMID 11699879.CS1 maint: Multiple names: authors list (link)
• Bohnsack MT, Regener K, Schwappach B; et al. (2003). "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm". EMBO J. 21 (22): 6205–15. PMID 12426392.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Olsen DS, Savner EM, Mathew A; et al. (2003). "Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo". EMBO J. 22 (2): 193–204. doi:10.1093/emboj/cdg030. PMID 12514125.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535–40. doi:10.1073/pnas.0437845100. PMID 12569173.CS1 maint: Multiple names: authors list (link)
• Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ross MT, Grafham DV, Coffey AJ; et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim S, Kim GJ, Miyoshi H; et al. (2007). "Efficiency of the elongation factor-1alpha promoter in mammalian embryonic stem cells using lentiviral gene delivery systems". Stem Cells Dev. 16 (4): 537–45. doi:10.1089/scd.2006.0088. PMID 17784828.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)