Drug-induced lupus erythematosus (patient information): Difference between revisions

	Drug-induced lupus erythematosus
Overview
What are the symptoms?
What are the causes?
Who is at highest risk?
Diagnosis
;
When to seek urgent medical care
Treatment options
Where to find medical care for Drug-induced lupus erythematosus ?
What to expect (Outlook/Prognosis)?
Possible complications
Drug-induced lupus erythematosus On the Web
Ongoing Trials at Clinical Trials.gov
Images of Drug-induced lupus erythematosus
Videos on Drug-induced lupus erythematosus
FDA on Drug-induced lupus erythematosus
CDC on Drug-induced lupus erythematosus
Drug-induced lupus erythematosus in the news
Blogs on Drug-induced lupus erythematosus
Directions to Hospitals Treating Drug-induced lupus erythematosus
Risk calculators and risk factors for Drug-induced lupus erythematosus

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Latest revision as of 16:50, 22 June 2016

For the WikiDoc page for this topic, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Jinhui Wu, MD; Ujjwal Rastogi, MBBS [2]

Overview

Drug-induced lupus erythematosus is a side-effect of long-term use of certain medications. The most commom medications that cause drug-induced lupus erythematosus are procainamide, hydralazine and quinidine. Symptoms of drug-induced lupus erythematosus are similar to systemic lupus erythematosus. After stopping the medication that caused the condition, most patients may recover.

What are the symptoms of Drug-induced lupus erythematosus?

Symptoms of drug-induced lupus erythematosus always occur after taking the drug for at least 3 to 6 months. Common symptoms are similar to systemic lupus erythemathosus.

Fatigue and weakness
Low fever
Muscle pain
Joint pain
Loss of appetite
Facial butterfly rash
Sensitivity to sunlight
Chest pain
Swollen lymph nodes

What causes Drug-induced lupus erythematosus?

Drug-induced lupus erythematosus is caused by a hypersensitivity reaction to a medication. Several following medications are known to cause drug-induced lupus:

Who is at highest risk?

The major risk factor for developing drug-induced lupus is chronic, long-term use of a drug known to cause Drug induced lupus.

Diagnosis

The health care provider will listen to your chest with a stethoscope. The doctor may hear a sound called a heart friction rub or pleural friction rub. There may be signs of pericarditis.

A skin exam shows a rash.

Tests that may be done include:

Antihistone antibody
Antinuclear antibody (ANA) panel
Lupus erythematosus cell test (rarely used)

A chest x-ray may show signs of pleuritis or pericarditis. An ECG may show that the heart is affected.

When to seek urgent medical care

Treatment options

Generally, symptoms of drug-induced lupus erythematosus may disappear within several days to weeks after stopping the medication that caused the condition.

Stop the medications that caused the problem.
Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs may be used to control inflammation and pain in patients with pain and other symptoms. Usual drugs include ibuprofen, naproxen and indomethacin. Usual side effects are pain, bleeding and ulcers in upper gastrointestinal tract.
Corticosteroids: Corticosteroids can be used to control many symptoms such as pain and rash. Side effects of corticosteroids may include a decreased ability against infection, worse healing in the wound and osteoporosis.
Antimalarial drugs: These drugs can be used to treat rash and arthritis in patients with drug-induced lupus erythematosus.

Where to find medical care for Drug-induced lupus erythematosus?

Directions to Hospitals Treating Drug-induced lupus erythematosus

What to expect (Outlook/Prognosis)?

Prognosis of drug-induced lupus erythematosus is better than systemic lupus erythemathosus. Symptoms usually disappear within several days to weeks after stopping the medication that caused the condition.

Possible complications

Infection
Thrombocytopenia purpura -- bleeding near the skin surface, resulting from a low number of platelets in the blood
Hemolytic anemia
Myocarditis
Percarditis

Sources

http://www.nlm.nih.gov/medlineplus/ency/article/000446.htm

@@ Line 1: / Line 1: @@
 '''For the WikiDoc page for this topic, click [[Drug-induced lupus erythematosus|here]]'''
-{{SI}}
+{{Drug-induced lupus erythematosus (patient information)}}
-{{CMG}};  Jinhui Wu, MD
+{{CMG}}; '''Associate Editor-In-Chief''': Jinhui Wu, MD; [[User:Ujjwal Rastogi|Ujjwal Rastogi, MBBS]] [mailto:urastogi@perfuse.org]
-{{EJ}}
+==Overview==
+Drug-induced lupus erythematosus is a [[side-effect]] of long-term use of certain medications. The most commom medications that cause drug-induced lupus erythematosus are [[procainamide]], [[hydralazine]] and [[quinidine]]. Symptoms of drug-induced lupus erythematosus are similar to systemic lupus erythematosus. After stopping the medication that caused the condition, most patients may recover.
-==Overview of drug-induced lupus erythematosus==
+==What are the symptoms of Drug-induced lupus erythematosus?==
+Symptoms of drug-induced lupus erythematosus always occur after taking the drug for at least 3 to 6 months. Common symptoms are similar to systemic lupus erythemathosus.
+:*[[Fatigue]] and [[weakness]]
+:*Low [[fever]]
+:*Muscle pain
+:*[[Joint pain]]
+:*[[Loss of appetite]]
+:*Facial [[butterfly rash]]
+:*Sensitivity to sunlight
+:*[[Chest pain]]
+:*[[Swollen]] [[lymph node]]s
-==What cause drug-induced lupus erythematosus?==
+==What causes Drug-induced lupus erythematosus?==
 Drug-induced lupus erythematosus is caused by a hypersensitivity reaction to a medication. Several following medications are known to cause drug-induced lupus:
 :*[[Procainamide]]
@@ Line 20: / Line 31: @@
 :*[[Sulfasalazine]]
-==How do I know if I have drug-induced lupus erythematosus and what are the symptoms of drug-induced lupus erythematosus?==
+==Who is at highest risk?==
-Symptoms of drug-induced lupus erythematosus always occur after taking the drug for at least 3 to 6 months. Common symptoms are similar to systemic lupus erythemathosus.
+The major risk factor for developing drug-induced lupus is chronic, long-term use of a drug known to cause Drug induced lupus.
-:*[[Fatigue]] and [[weakness]]
-:*Low [[fever]]
+==Diagnosis==
-:*Muscle pain
+The health care provider will listen to your chest with a stethoscope. The doctor may hear a sound called a heart friction rub or pleural friction rub. There may be signs of [[pericarditis (patient information)| pericarditis]].
-:*[[Joint pain]]
-:*[[Loss of appetite]]
+A skin exam shows a rash.
-:*Facial [[butterfly rash]]
-:*Sensitivity to sunlight
+Tests that may be done include:
-:*[[Chest pain]]
-:*[[Swollen]] [[lymph node]]s
+* Antihistone antibody
+* Antinuclear antibody (ANA) panel
+* Lupus erythematosus cell test (rarely used)
+A chest x-ray may show signs of [[pleuritis (patient information)|pleuritis]] or pericarditis. An ECG may show that the heart is affected.
+==When to seek urgent medical care==
 ==Treatment options==
@@ Line 38: / Line 55: @@
 :*[[Corticosteroid]]s: Corticosteroids can be used to control many symptoms such as pain and [[rash]]. [[Side effect]]s of corticosteroids may include a decreased ability against [[infection]], worse healing in the wound and [[osteoporosis]].
 :*[[Antimalarial drug]]s: These drugs can be used to treat [[rash]] and [[arthritis]] in patients with drug-induced lupus erythematosus.
+==Where to find medical care for Drug-induced lupus erythematosus?==
+[http://maps.google.com/maps?hl=en&q=drug-induced%20lupus%20erythematosus&gs_sm=e&gs_upl=54816l54816l0l55142l1l1l0l0l0l0l93l93l1l1l0&bav=on.2,or.r_gc.r_pw.&biw=1600&bih=799&safe=active&um=1&ie=UTF-8&sa=N&tab=wl Directions to Hospitals Treating Drug-induced lupus erythematosus]
 ==What to expect (Outlook/Prognosis)?==
 Prognosis of drug-induced lupus erythematosus is better than systemic lupus erythemathosus. Symptoms usually disappear within several days to weeks after stopping the medication that caused the condition.
-==Copyleft Sources==
+==Possible complications==
+* Infection
+* Thrombocytopenia [[purpura (patient information)|purpura]] -- bleeding near the skin surface, resulting from a low number of platelets in the blood
+* [[Hemolytic anemia (patient information)|Hemolytic anemia]]
+* [[Myocarditis (patient information)|Myocarditis]]
+* [[Pericarditis (patient information)|Percarditis]]
+==Sources==
 http://www.nlm.nih.gov/medlineplus/ency/article/000446.htm
-http://www.lupus.org/webmodules/webarticlesnet/templates/new_aboutindividualized.aspx?articleid=377&zoneid=18
-http://emedicine.medscape.com/article/1065086-overview
-http://dermnetnz.org/reactions/drug-induced-lupus.html
 ==See also==
 :*[[Systemic lupus erythematosus (patient information)]]
 {{WH}}
 {{WS}}
-[[Category:Patient Information]]
+[[Category:Disease]]
+[[Category:Nephrology]]
+[[Category:Rheumatology]]
+[[Category:Rheumatology patient information]]
+[[Category:Patient information]]
+[[Category:Overview complete]]
+[[Category:For review]]