Diverticulosis risk factors: Difference between revisions

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{{Diverticulosis}}
{{Diverticulosis}}
{{CMG}}{{AE}} [[User:Seyedmahdi Pahlavani|Seyedmahdi Pahlavani, M.D.]]
{{CMG}} {{AE}} {{MehdiP}}
 
==Overview==
==Overview==
Risk factors for diverticulosis include low intake of dietary fiber, high intake of fat and red meat, and obesity.
Risk factors in the development of diverticulosis include advanced age, chronic [[constipation]], [[connective tissue disease]]s (such as [[Marfan syndrome]] or [[Ehlers Danlos syndrome]]), low dietary fiber intake, high intake of fat and red meat, and obesity.
==Risk Factors==
==Risk Factors==
Risk factors for diverticulosis include the following:
Risk factors in the development of diverticulosis include the following:<ref name="pmid18996378">{{cite journal |vauthors=Strate LL, Liu YL, Aldoori WH, Syngal S, Giovannucci EL |title=Obesity increases the risks of diverticulitis and diverticular bleeding |journal=Gastroenterology |volume=136 |issue=1 |pages=115–122.e1 |year=2009 |pmid=18996378 |pmc=2643271 |doi=10.1053/j.gastro.2008.09.025 |url=}}</ref>
# '''Diet'''
*Advanced age
#*'''''Fiber''''': The role of fiber in the development of [[diverticulosis]] is unclear. Several early studies suggested that low dietary fiber predisposes to the development of diverticular disease, but other studies have been conflicting.<ref name="pmid23891924">{{cite journal |vauthors=Peery AF, Sandler RS, Ahnen DJ, Galanko JA, Holm AN, Shaukat A, Mott LA, Barry EL, Fried DA, Baron JA |title=Constipation and a low-fiber diet are not associated with diverticulosis |journal=Clin. Gastroenterol. Hepatol. |volume=11 |issue=12 |pages=1622–7 |year=2013 |pmid=23891924 |pmc=3840096 |doi=10.1016/j.cgh.2013.06.033 |url=}}</ref> However, dietary fiber and a vegetarian diet may reduce the incidence of symptomatic diverticular disease by decreasing intestinal inflammation and altering the intestinal microbiota.<ref name="pmid7942584">{{cite journal |vauthors=Aldoori WH, Giovannucci EL, Rimm EB, Wing AL, Trichopoulos DV, Willett WC |title=A prospective study of diet and the risk of symptomatic diverticular disease in men |journal=Am. J. Clin. Nutr. |volume=60 |issue=5 |pages=757–64 |year=1994 |pmid=7942584 |doi= |url=}}</ref>
*Chronic [[constipation]]
#*'''''Fat and red meat''''': The risk of diverticular disease is significantly increased with diets that are low in fiber and are high in total fat or red meat as compared with diets that are low in both fiber and total fat or red meat.<ref name="pmid7942584">{{cite journal |vauthors=Aldoori WH, Giovannucci EL, Rimm EB, Wing AL, Trichopoulos DV, Willett WC |title=A prospective study of diet and the risk of symptomatic diverticular disease in men |journal=Am. J. Clin. Nutr. |volume=60 |issue=5 |pages=757–64 |year=1994 |pmid=7942584 |doi= |url=}}</ref>
*Connective tissue disorders
#*'''''Seeds and nuts''''': Nut, corn, and popcorn consumption are not associated with an increase in risk of diverticulosis,diverticulitis or diverticular bleeding.<ref name="pmid18728264">{{cite journal |vauthors=Strate LL, Liu YL, Syngal S, Aldoori WH, Giovannucci EL |title=Nut, corn, and popcorn consumption and the incidence of diverticular disease |journal=JAMA |volume=300 |issue=8 |pages=907–14 |year=2008 |pmid=18728264 |pmc=2643269 |doi=10.1001/jama.300.8.907 |url=}}</ref>
:*[[Marfan syndrome]]
#'''Physical activity'''
:*[[Ehlers Danlos syndrome]]
#*It is unclear if lack of vigorous exercise is a risk factor for diverticular disease. However, vigorous physical activity appears to reduce the risk of diverticulitis and diverticular bleeding.<ref name="pmid7883230">{{cite journal |vauthors=Aldoori WH, Giovannucci EL, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, Wing AL, Trichopoulos DV, Willett WC |title=Prospective study of physical activity and the risk of symptomatic diverticular disease in men |journal=Gut |volume=36 |issue=2 |pages=276–82 |year=1995 |pmid=7883230 |pmc=1382417 |doi= |url=}}</ref>
*Low fiber diet
# '''Obesity'''
:*The role of fiber in the development of [[diverticulosis]] remains unclear. ALthough classically low fiber diet has been associated with development of diverticulosis, results from newer studies are conflicting.<ref name="pmid23891924">{{cite journal |vauthors=Peery AF, Sandler RS, Ahnen DJ, Galanko JA, Holm AN, Shaukat A, Mott LA, Barry EL, Fried DA, Baron JA |title=Constipation and a low-fiber diet are not associated with diverticulosis |journal=Clin. Gastroenterol. Hepatol. |volume=11 |issue=12 |pages=1622–7 |year=2013 |pmid=23891924 |pmc=3840096 |doi=10.1016/j.cgh.2013.06.033 |url=}}</ref> However, dietary fiber and a vegetarian diet may reduce the incidence of symptomatic diverticular disease by decreasing intestinal inflammation and altering the intestinal microbiota.<ref name="pmid7942584">{{cite journal |vauthors=Aldoori WH, Giovannucci EL, Rimm EB, Wing AL, Trichopoulos DV, Willett WC |title=A prospective study of diet and the risk of symptomatic diverticular disease in men |journal=Am. J. Clin. Nutr. |volume=60 |issue=5 |pages=757–64 |year=1994 |pmid=7942584 |doi= |url=}}</ref><ref name="pmid4930390">{{cite journal| author=Painter NS, Burkitt DP| title=Diverticular disease of the colon: a deficiency disease of Western civilization. | journal=Br Med J | year= 1971 | volume= 2 | issue= 5759 | pages= 450-4 | pmid=4930390 | doi= | pmc=PMC1796198 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=4930390  }} </ref>
#*It has been associated with an increase in risk of both diverticulitis and diverticular bleeding.<ref name="pmid18996378">{{cite journal |vauthors=Strate LL, Liu YL, Aldoori WH, Syngal S, Giovannucci EL |title=Obesity increases the risks of diverticulitis and diverticular bleeding |journal=Gastroenterology |volume=136 |issue=1 |pages=115–122.e1 |year=2009 |pmid=18996378 |pmc=2643271 |doi=10.1053/j.gastro.2008.09.025 |url=}}</ref>
*High fiber and red meat diet
:*The risk of diverticulosis may be significantly increased with diets that are high in total fat or red meat compared with fat and red meat-rich diets.<ref name="pmid7942584">{{cite journal |vauthors=Aldoori WH, Giovannucci EL, Rimm EB, Wing AL, Trichopoulos DV, Willett WC |title=A prospective study of diet and the risk of symptomatic diverticular disease in men |journal=Am. J. Clin. Nutr. |volume=60 |issue=5 |pages=757–64 |year=1994 |pmid=7942584 |doi= |url=}}</ref>
*Obesity


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Seyedmahdi Pahlavani, M.D. [2]

Overview

Risk factors in the development of diverticulosis include advanced age, chronic constipation, connective tissue diseases (such as Marfan syndrome or Ehlers Danlos syndrome), low dietary fiber intake, high intake of fat and red meat, and obesity.

Risk Factors

Risk factors in the development of diverticulosis include the following:[1]

  • Advanced age
  • Chronic constipation
  • Connective tissue disorders
  • Low fiber diet
  • The role of fiber in the development of diverticulosis remains unclear. ALthough classically low fiber diet has been associated with development of diverticulosis, results from newer studies are conflicting.[2] However, dietary fiber and a vegetarian diet may reduce the incidence of symptomatic diverticular disease by decreasing intestinal inflammation and altering the intestinal microbiota.[3][4]
  • High fiber and red meat diet
  • The risk of diverticulosis may be significantly increased with diets that are high in total fat or red meat compared with fat and red meat-rich diets.[3]
  • Obesity

References

  1. Strate LL, Liu YL, Aldoori WH, Syngal S, Giovannucci EL (2009). "Obesity increases the risks of diverticulitis and diverticular bleeding". Gastroenterology. 136 (1): 115–122.e1. doi:10.1053/j.gastro.2008.09.025. PMC 2643271. PMID 18996378.
  2. Peery AF, Sandler RS, Ahnen DJ, Galanko JA, Holm AN, Shaukat A, Mott LA, Barry EL, Fried DA, Baron JA (2013). "Constipation and a low-fiber diet are not associated with diverticulosis". Clin. Gastroenterol. Hepatol. 11 (12): 1622–7. doi:10.1016/j.cgh.2013.06.033. PMC 3840096. PMID 23891924.
  3. 3.0 3.1 Aldoori WH, Giovannucci EL, Rimm EB, Wing AL, Trichopoulos DV, Willett WC (1994). "A prospective study of diet and the risk of symptomatic diverticular disease in men". Am. J. Clin. Nutr. 60 (5): 757–64. PMID 7942584.
  4. Painter NS, Burkitt DP (1971). "Diverticular disease of the colon: a deficiency disease of Western civilization". Br Med J. 2 (5759): 450–4. PMC 1796198. PMID 4930390.

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